Gene Information

Name : guaA (GFO_2228)
Accession : YP_862260.1
Strain : Gramella forsetii KT0803
Genome accession: NC_008571
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2370689 - 2372218 bp
Length : 1530 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAAAACAACGTACTCATCCTAGACTTTGGCTCGCAGTACACGCAGCTTATCGCGCGTAGAGTTAGAGAGCTGAATAT
TTACTGTGAAATTTATCCTTATCATAAGATCCCGGAAGATTTATCAGGTTTTAAAGCGGTAATTCTTTCCGGAAGTCCGT
TTTCTGTGAGAGCTGAAGATGCACCGCATCCGGACCTTTCTCAGATTCGTGGAAAATTGCCCATTCTGGCTGTTTGTTAT
GGAGCTCAGTATTTTGCCCATTTTCATGGGGGAAAAGTAGAACCTTCAGATACAAGGGAATATGGTAGAGCTAATCTTAC
AGTTATTAAGGATGCCGAACCATTATTCGAAAACATCAAAGAAAATTCCCAGGTGTGGATGAGTCATAGTGATTCTATCA
TCAGATTGCCTGAAAATGGAGTGAGACTGGCAAGTACTTCAGATGTTCTGAATGCAGCCTATAGAATTGAAGGAGAACAA
ACTTTTGCGATACAGTTTCATCCTGAAGTTTATCATTCAACAGACGGAAAACAATTACTTGAAAATTTCCTTATAAAGAT
TGCAGGTACTAAAGCAACCTGGACACCTGGTAAGTTTGTAGATCTTACAGTTTCAGAATTAAAGGAGAAGGTTGGGGATG
ATAAAGTGGTACTTGGTTTGAGTGGTGGAGTAGATTCTACAGTTGCCGCGGTACTTCTGCATAAAGCTATCGGGAAAAAC
CTTTATTGCATTTTTGTAAATAACGGATTGTTGAGAAAGAATGAATTTGAGAGCGTTCTTGATCAATATAAAGATATGGG
GCTTAACGTTAAAGGCGTTGATGCTTCGGCACGTTTCTTGGATGCCCTAAAAGGATTAAGTGATCCTGAAGAAAAGCGTA
AAGCGATTGGAAATACTTTCATCGAAGTTTTTGATGATGAGGCGCACGAGATTAAAGATGTGGTATATTTAGCACAGGGT
ACTATTTATCCTGATGTGATAGAATCTGTTTCAGTAAACGGGCCTTCAGTAACTATTAAATCGCATCATAATGTGGGTGG
TTTACCTGACTTTATGAAACTTAAAATTGTGGAACCTCTAAGAATGTTGTTTAAAGATGAGGTAAGACGTGTAGGAAAGG
AACTTGGAATAGATAAAGAATTACTGGGCAGACATCCATTTCCGGGACCAGGACTGGCGATTAGAATTTTAGGGGATATT
ACAGAAGAGAAAGTAAGGATCCTTCAGGAAGTAGATCATATTTTTATTCAGGGATTAAGGGACTGGATGTTATATGATAA
AGTATGGCAGGCAGGAGCAATTTTACTGCCAATTCAGTCGGTTGGAGTAATGGGAGATGAGCGAACTTATGAGCAGGTTG
TAGCACTTCGAGCAGTTGAATCTACCGATGGAATGACGGCAGACTGGGTAAATTTACCTTATGAATTTTTACAGAAAACA
TCCAATACAATAATTAACAGGGTAAAGGGCGTTAATAGAGTGGTATATGATATTAGTTCTAAACCACCGGCAACCATAGA
ATGGGAATAA

Protein sequence :
MQNNVLILDFGSQYTQLIARRVRELNIYCEIYPYHKIPEDLSGFKAVILSGSPFSVRAEDAPHPDLSQIRGKLPILAVCY
GAQYFAHFHGGKVEPSDTREYGRANLTVIKDAEPLFENIKENSQVWMSHSDSIIRLPENGVRLASTSDVLNAAYRIEGEQ
TFAIQFHPEVYHSTDGKQLLENFLIKIAGTKATWTPGKFVDLTVSELKEKVGDDKVVLGLSGGVDSTVAAVLLHKAIGKN
LYCIFVNNGLLRKNEFESVLDQYKDMGLNVKGVDASARFLDALKGLSDPEEKRKAIGNTFIEVFDDEAHEIKDVVYLAQG
TIYPDVIESVSVNGPSVTIKSHHNVGGLPDFMKLKIVEPLRMLFKDEVRRVGKELGIDKELLGRHPFPGPGLAIRILGDI
TEEKVRILQEVDHIFIQGLRDWMLYDKVWQAGAILLPIQSVGVMGDERTYEQVVALRAVESTDGMTADWVNLPYEFLQKT
SNTIINRVKGVNRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-113 49
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-113 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-113 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-109 46