Gene Information

Name : topB (AHA_4047)
Accession : YP_858472.1
Strain : Aeromonas hydrophila ATCC 7966
Genome accession: NC_008570
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 4483649 - 4485619 bp
Length : 1971 bp
Strand : -
Note : decatenates replicating daughter chromosomes

DNA sequence :
ATGCGACTCTTCATCGCCGAGAAGCCCAGTCTGGGACGTGCCATTGCCGACGTGCTGCCCAAGCCCCACAAGAAGGGGGA
CGGTTTTATCGAAACCGCGCAGGGGGATGTGGTGACCTGGTGCATCGGCCATCTGCTGGAGCAGGCCGAGCCGGATGCCT
ATGACGCCGCCTACAAGCAGTGGCGCATGGAGTCGCTACCCATCGTCCCGAGCCAGTGGCAACTGGTGGCCAAGCCGAAG
ACCAAGACCCAGCTCACCGTCATCAAGCGCCTGCTCAAGCAGGCCGACTGCGTGGTCAACGCCGGTGACCCGGACCGGGA
GGGGCAGCTGCTGGTGGACGAGGTGATCGATTTCCTCGGCTACGGCAAAACCAGGCCGGTGCTGCGCTGTCTCATCAGCG
ATCTCAACCCACCGGCGGTGCGCCGTGCCCTCGACAAGCTCAGGGACAACAAGGAGTTCGTGCCGCTGGCGGTGTCGGCG
CTGGCCCGCAGCCGGGCCGACTGGCTCTACGGCATCAACATGACCCGCGCCTATACCCTGCTTGGCCGCAAGGGGGGTTG
CAGCGAGCTGCTGTCGGTCGGTCGGGTACAGACGCCGCTGCTGGGGCTGGTGGTACGGCGGGATCTCGAGATAGAAGCCT
TCGTGCCCAAGCCCTTCTTCGAGGTGCTGGCCCATCTACAGACCGAAGGCAACGAGCGTTTCAGCGCCAAGTGGCTGCCT
TCCGAGGCCTGTCTGCCCTGGCAGGACGAGGAGGGTCGTGTGCTCAACCGGGCGCTGGCCGCCAAGGTGGTGGAGCGGAT
CCAGGGTCAACCCGCACTGGTGGAGGAGGTGGAGGAGCAGGCCCGCAAGCAGGCGGCGCCGCTGCCCTACAACCTCTCCA
GCCTGCAGATCGATGCCGCCAAGCGGTTCGGCATGGACGCCAAGCGGGTGCTGGACGTCTGCCAGGGGCTCTACGAGCGC
CACAAGCTGATTACCTACCCGCGATCCGACAGCCGTCATCTGCCGAGCGATCACTTCAACCGGGCCGGCCAGGTGCGGGA
GGCCATCGCCAGCACGGCGCCGGCGCTGGCCAAGGCGGTGAGCGAGGCGGACGGCAAGATCCGCAGCAAGGCGTGGAACG
ACGGCAAGGTGGACGCTCACCATGCCATCATCCCCACCGAGAAGCAGGGCAACCCGGCCACGCTGGGGGCTGACGAGGCG
AAGCTTTACGGCCTGATTGCCCGTCAGTACCTGCTGCAGTTCTACCCGCCGTTCGAGTACAACGACAGCAAGGTGCTGCT
GCGCATCGCCGGCGGCCTGTTCCAGGCCAAGGCGCGGCGGATCCTCAAGGCGGGCTGGAAGGCCCTATTGGGGGTGGAAG
AAGATGACGACGAAGAGAAAGCCGGTACCCTGCCCGCCCTGAAAGAGGGGGAGCAGCTGCTGTGCGAGCGGGGGGCGCTG
CTGGAGAAGATGACCCAGGCACCCAAGTCGTTCACCGATGCCACCCTGCTGGCCGCCATGACCGGCATCGCCCGCTACGT
GCAGGACCCCGAGATCCGCAAGACACTGCGCGAGACCGACGGTCTCGGCACCGAGGCGACCCGGGCGGGCATCATAGATC
TGCTGTTCAAGCGCCGTTTTCTGGTGCGCCAGGGCAAGAGCATCAAGGGCACCCCCACCGGACGGGCGCTGATCCTGGCG
CTGCCTGCCACCGCCACCACGCCGGACATGACGGCGTTGTGGGAGCAGCACCTCGGCCGGATTGCCGAGCGGCAGACGAG
CTATCAGCAATTCATGGGGCCGCTGACCGAGCAGTTGAACGGCCTGATCGACGGCGCCAGACAGGATTCGGGGGCCAGCT
TCAGCGCCCTGCCCAAGGCGGTGCCCGGAGCCGACAAACGCCGCTTCACCAAGCGCAAGCGCAGCACGGCGGCTGGTGGC
ACGAGCGGGACAGCCAAGCGGGGGAGCAAGCGGCCGGCCAAGGCTGCCTGA

Protein sequence :
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAYKQWRMESLPIVPSQWQLVAKPK
TKTQLTVIKRLLKQADCVVNAGDPDREGQLLVDEVIDFLGYGKTRPVLRCLISDLNPPAVRRALDKLRDNKEFVPLAVSA
LARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFFEVLAHLQTEGNERFSAKWLP
SEACLPWQDEEGRVLNRALAAKVVERIQGQPALVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYER
HKLITYPRSDSRHLPSDHFNRAGQVREAIASTAPALAKAVSEADGKIRSKAWNDGKVDAHHAIIPTEKQGNPATLGADEA
KLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGAL
LEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFKRRFLVRQGKSIKGTPTGRALILA
LPATATTPDMTALWEQHLGRIAERQTSYQQFMGPLTEQLNGLIDGARQDSGASFSALPKAVPGADKRRFTKRKRSTAAGG
TSGTAKRGSKRPAKAA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 4e-114 44
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 3e-114 44
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 4e-114 44
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 1e-105 42
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 2e-95 42