Gene Information

Name : entE (AHA_2478)
Accession : YP_856992.1
Strain : Aeromonas hydrophila ATCC 7966
Genome accession: NC_008570
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 2754548 - 2756209 bp
Length : 1662 bp
Strand : -
Note : bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate

DNA sequence : 
ATGACCCAGTCCAACCGCTTCCTGCCCTATACCCGCTGGCCCGAGGAATTGGCCCGGCAGTACCGCGCCAAGGGCTATTG
GCGTGGCGAGCCGCTGACCGCCATGCTGGCGCGTCAGTGCGAACTGGCCCCCGACGCCGAGGCCATCCTCTGCGGCGAGC
GCCGCTTCAGCTATCGCGAGCTGGACACCGCCTCGAGCCGGCTGGCCGCGAATCTGGCTCACCACGGCCTGGGGGCGGGG
GATACCGCGCTGGTGCAGCTCCCCAACGTGGCTGAGTTCTATCTGGTGTTCTTCGCCCTGCTCAAGGCCGGCATCGCGCC
GGTCAACGCGCTCTTTAGCCACAACCGGCTGGAGCTCCTCTCTTATGCCGAGCAGATCACACCGCGCCTCTTTATCGGCT
CGCTGGCCCATCCGCTGTTTGCGAGCAAGGGACGCGAGAGCGAGCTGCTGAAAACCATAGGCGCCGAACTGGTGCTACTG
GATGGCGAGAGTGGGGAACTGGGGCTGACCCACTGGTTGGCGAAGGGTGCTGAGGGTGAGCCGGTGAAATCTGGCCCGAC
CCCGGCGGACGAGGTGGCCTTCTTCCAGCTCTCCGGTGGCAGCACCGGCACTCCCAAGCTCATCCCCCGCACCCATGACG
ACTACCTGTACAGCGTGCGCCGCAGCAATGAAATCTGTGAATTGGGGCCCCACACCCGCTATCTGTGCGCCCTGCCGGCG
CCCCACAACTTCCCCCTGAGCTCCCCGGGCGCCCTGGGGGTATTCGAGGCGGGTGGCGCCGTGGTGCTCGCACCCGATCC
CAGCCCCATCAGCTGTTTCCCGCTGATCGCCCGCCACCGGGTCAATCTCACCTCGCTGGTGCCGCCGGCGGTCTCGCTCT
GGCTGCAGGCAGCGGAAGCGGACCCCACTGCGCGCACTCAGCTCGAGAGCCTCGACTTGCTGCAAGTGGGCGGCGCCAAG
CTGGGGGAGGCGGTGGCCAGCAAGATAGGGCCGCTACTCGGCTGCCGGCTGCAGCAGGTGTTCGGCATGGCGGAGGGGCT
GGTCAACTACACCCGGCTGGATGACCCCGACGAGAAGGTCATTCACACCCAGGGCCGCCCCATGAGCCCGGACGACGAGG
TGCGCATCCTCGATGAGGCGGGCAACCCGGTCGCCCCCGGCGAGCCTGGCGCCCTGCACACCCGTGGCCCCTATACCTTC
CGCGGTTACTACCAGAGCCCGGCCCACAACGCCCGGGTGTTCGATGCCGAGGGTTTCTACTGCTCCGGCGATCTGGTGGT
ACAGGATGCCGATGGTTACCTCACCGTGGTGGGGAGGCAGAAGGATCAGATCAACCGGGGCGGCGAGAAGATCGCGGCGG
AAGAGGTGGAAAACCAGCTGCTGCACCATCCGGCCATCACCCATGCGGCCCTGGTCTCCATGCCCGACAGCGCCATGGGG
GAGAAGAGCTGTGCCTTCATCGTCAGCACGGATCCCGCCTTGAAGCCGCTGGCCTTGCGCAAGTTTCTGCGCGAGCGCGG
GGTGGCGGACTTCAAGCTGCCAGACCGTTTCGAAACCCTGGATGCCCTGCCCATGACGGCGGTGGGCAAGATTGACAAGC
AGGGGCTGCGGGCGCGCATTGCGCACCTCATAGCCGCCGGCAATCCCCTGACAACAGCATAA

Protein sequence : 
MTQSNRFLPYTRWPEELARQYRAKGYWRGEPLTAMLARQCELAPDAEAILCGERRFSYRELDTASSRLAANLAHHGLGAG
DTALVQLPNVAEFYLVFFALLKAGIAPVNALFSHNRLELLSYAEQITPRLFIGSLAHPLFASKGRESELLKTIGAELVLL
DGESGELGLTHWLAKGAEGEPVKSGPTPADEVAFFQLSGGSTGTPKLIPRTHDDYLYSVRRSNEICELGPHTRYLCALPA
PHNFPLSSPGALGVFEAGGAVVLAPDPSPISCFPLIARHRVNLTSLVPPAVSLWLQAAEADPTARTQLESLDLLQVGGAK
LGEAVASKIGPLLGCRLQQVFGMAEGLVNYTRLDDPDEKVIHTQGRPMSPDDEVRILDEAGNPVAPGEPGALHTRGPYTF
RGYYQSPAHNARVFDAEGFYCSGDLVVQDADGYLTVVGRQKDQINRGGEKIAAEEVENQLLHHPAITHAALVSMPDSAMG
EKSCAFIVSTDPALKPLALRKFLRERGVADFKLPDRFETLDALPMTAVGKIDKQGLRARIAHLIAAGNPLTTA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-83 45
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-83 45
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 7e-83 45
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-83 45
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-83 45
ybtE CAA21394.1 - Virulence HPI Protein 7e-83 45
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-81 44
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-81 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 7e-83 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE YP_856992.1 enterobactin synthase subunit E VFG0932 Protein 2e-156 62
entE YP_856992.1 enterobactin synthase subunit E VFG0168 Protein 3e-115 49
entE YP_856992.1 enterobactin synthase subunit E VFG1817 Protein 1e-89 44