Gene Information

Name : guaA (Bcen2424_1989)
Accession : YP_835633.1
Strain :
Genome accession: NC_008542
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2204975 - 2206594 bp
Length : 1620 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACCCAACTGATTGCACGGCGCGTGCGTGAAGCGCACGT
CTACTGCGAAATCCATCCGAACGACGTGTCCGACGACTTCGTCCGCGAGTTCGCGCCGAAGGCGGTGATCCTGTCGGGCA
GCCACGCGAGCACGTACGAAGACCATCAACTGCGCGCGCCGCAGGCCGTGTGGGATCTCGGCGTGCCGGTGCTCGGCATC
TGCTACGGCATGCAGACGATGGCCGTGCAGCTCGGCGGCAAGGTCGAGTGGAGCGACCATCGCGAATTCGGCTACGCGGA
AATGCGTGCGCACGGCCATACGCGCCTGCTCGACGGCATCGAGGATTTCACGACGGCCGAAGGCCACGGGATGCTGAAGG
TCTGGATGAGCCACGGCGACAAGGTGGCCGAGCTGCCGCCGGGCTTCGCGCTGATGGCGTCGACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCACCCGGAAGTCACGCACACGGTGAAGGGCCGCCA
GATCATCGAGCGCTTCGTGCTGCAGATCGCCGGCGCGAAGCCCGACTGGATCATGAAGAACCACATCGAGGAAGCCGTCG
CGAAGATCCGCGAGCAGGTCGGTGACGAGGAAGTGATTCTCGGCCTGTCGGGCGGCGTCGATTCGAGCGTCGCGGCCGCG
CTGATCCATCGCGCGATCGGCGATCAACTGACCTGCGTGTTCGTCGACCACGGCCTGCTGCGCCTGAACGAAGGCAAGAT
GGTGCTCGACATGTTCGAGGGCCGCCTGCATGCGAAGGTCGTGCACGTCGACGCATCCGACCAGTTCCTCGGCCATCTGG
CCGGCGTGACCGATCCGGAAGCGAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAGGTGTTCCAGGCCGAGGCGAAGAAG
CTGTCGAAGGCGAAGTGGCTCGCGCAGGGCACGATCTACCCGGACGTGGTCGAATCGGGCGGCACGAAGACGAAGAAGGC
GACGACGATCAAGAGCCACCACAACGTCGGCGGCCTGCCGGAAACGCTCGGCCTGAAGCTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGACGAAGTGCGCGAGCTGGGTGTCGCGCTCGGCCTGCCGCCGGAGATGGTGTACCGCCATCCGTTCCCGGGC
CCGGGCCTCGGCGTGCGAATTCTCGGCGAAGTGAAGCGCGAATACGCGGAGCTGCTGCGCCGCGCGGACGCGATCTTCAT
CGAGGAACTGCGCAACACGACCGCGACCGCGCAGGACGCGGCTGCCGGCCTGTGCGGCGAGGCCGACGTCGGCAAGAGCT
GGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTCAAGTCGGTCGGCGTGATGGGCGATGGGCGGACATAC
GACTACGTGACGTCGCTGCGCGCGGTGCAGACGACCGACTTCATGACTGCGCATTGGGCGCATCTGCCGTATGCGCTGCT
CGGTCGCGCGTCGAATCGCATCATCAACGAAGTGCGCGGGATCAATCGGGTCGTGTACGACATCTCGGGGAAGCCGCCGG
CGACGATCGAGTGGGAGTGA

Protein sequence :
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYAELLRRADAIFIEELRNTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-117 49
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-117 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-117 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-108 49