Gene Information

Name : guaA (Acid_6467)
Accession : YP_827676.1
Strain : Candidatus Solibacter usitatus Ellin6076
Genome accession: NC_008536
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 8105841 - 8107577 bp
Length : 1737 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGAACCCTACAGCTCAGATCATCGTCCTCGATGCGGGGGGGCAGTATTGCCACCTCATTGCCCGGAAGGTGCGCGACCT
CGGCGTGTACGCGGAGGTGCGGGCGAGTGAGACGCCGGCGGCGGAGCTCGCGGCGGCGAAGGGAATCATTATCTCTGGCG
GGCCGAGCAGCGTATATGACCCGGAAAGCCCCACGGTAGACCCCGACATTTTCTCGCTGGGCATTCCGGTGCTTGGCATT
TGCTACGGGCAGCAGCTTATGGCCCACCTTTTGGGGGGCGAGGTACGTCCGGGGCAGAAGGGCGAGTACGGGCTGGCTAC
GCTCGATCTGGCGGAGACCGGCGATCCGCTGTTCGGGGGACTCGGCGGCACGCAGCAAGTGTGGATGAGTCACCGCGACG
TAGTGGGCCGCGCGCCTGAGGGGTTCGCGGTCACAGGTCGCACGGGCACTTGCGAGATCGCTGCGATCGCGGACCCCAAG
CGCAGGTTCTACGCGGTGCAATTCCACCTGGAAGTGGTCCACACGCCGCGGGGCAAGGAGTACCTCGCGAACTTCACGTT
CCGCGTCTGCGGATGCGTTCCGGATTGGGACCCGCGGAATCGCGTGCCGATGCTGGAGCAGGAGATCCGCGAGTGCGTGG
GCGAGCGCAGCGTCTTCTTCTTCGTCAGCGGCGGGGTGGATTCGAGTGTGGCGTTCGCGTTGTGCACCCGCGCGCTCAGC
GCCGACCGGGTGCGGGGTGTCTATGTAGACACCGGCCTGATGCGCGAGGGCGAGACTGATTTCGTGCGACGGATCGGCAA
TCTGACGGTCGAGCACGCGGAGGATCAGTTTCTGACCGCGCTGAGCGGCGTCACCGACCCCGAAACCAAGCGCCACATCA
TCGGCGAAGAGTTCGTTCGCGTTCAGGAGCGCATCATCGAGTCGCGCCACCTGATGAACGAGAACTGGATTCTGGGACAA
GGGACGATTTATCCGGACACGATCGAGAGCGGCGGCACGGCCAAGGCCGCGCTCATCAAGACGCATCACAATCGCGTGGC
CGGTATCCAGAAGCTGATCGCATGCGGGCGCATTGTGGAGCCGCTCAAATCTTTCTACAAGGATGAAGTCCGCGAGGTCG
GACGGGAGTTGGGCCTGTCCAGCGAGTTGCTGGACCGGCATCCGTTCCCGGGTCCGGGACTGGCGATTCGCTGCCTGTGC
TCGGAGTTCGATGCGCCGGTGCGGGCCACCGCCGAAGGGCTGATCGTGCCCGTGCACTCGGTCGGAGTGCAGGGCGATTC
GCGGACCTACGCGCCAGTGCTGGCGATCGATGCACTGGACCACTCGCGCGCCACGGAGTTGATCAATGCAATCGCGGGAG
TGAATCGCGTGATCGCGCCGGTGGAGACGGCGGCGCCCGCTTCGGAGATGCAGGTGCGCGCCTGCTCGTTGACGGAGGAG
CGATTGAAGCGCCTCAGAAGGGCGGATTCCATTGTCCGGCGACTGAGCCACGCCAGCGGCTACGATCACCAAGTCTGGCA
GTTTCCGGTGATCCTGATTCCGCTGGGTACGCAGGGGGCGCCGGATTCGGTGGTGCTGCGTCCTGTGGATTCGGTGGACG
GAATGACCGCGCAATCGGTCTTGATGGACGCGGAATTGTCACATGCCATCTGCGCGGAAGTGCTCCAGATCGGTGGCATC
GCCGGAGTCTTTTATGACCTCACCCACAAGCCGCCGGGCACAATTGAGTGGGAGTAG

Protein sequence :
MNPTAQIIVLDAGGQYCHLIARKVRDLGVYAEVRASETPAAELAAAKGIIISGGPSSVYDPESPTVDPDIFSLGIPVLGI
CYGQQLMAHLLGGEVRPGQKGEYGLATLDLAETGDPLFGGLGGTQQVWMSHRDVVGRAPEGFAVTGRTGTCEIAAIADPK
RRFYAVQFHLEVVHTPRGKEYLANFTFRVCGCVPDWDPRNRVPMLEQEIRECVGERSVFFFVSGGVDSSVAFALCTRALS
ADRVRGVYVDTGLMREGETDFVRRIGNLTVEHAEDQFLTALSGVTDPETKRHIIGEEFVRVQERIIESRHLMNENWILGQ
GTIYPDTIESGGTAKAALIKTHHNRVAGIQKLIACGRIVEPLKSFYKDEVREVGRELGLSSELLDRHPFPGPGLAIRCLC
SEFDAPVRATAEGLIVPVHSVGVQGDSRTYAPVLAIDALDHSRATELINAIAGVNRVIAPVETAAPASEMQVRACSLTEE
RLKRLRRADSIVRRLSHASGYDHQVWQFPVILIPLGTQGAPDSVVLRPVDSVDGMTAQSVLMDAELSHAICAEVLQIGGI
AGVFYDLTHKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-75 42
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-75 42
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-75 42