Gene Information

Name : lysS (STER_0733)
Accession : YP_820185.1
Strain : Streptococcus thermophilus LMD-9
Genome accession: NC_008532
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 666939 - 668429 bp
Length : 1491 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGCCAAATCAACACATGGAAGAATTAAACGATCAACAGATTGTCCGTCGTGAAAAAATGGCGGCCTTGGCTGAACAAGG
AATCGATCCTTTTGGTAAGCGATTCGAACGCACAGCTACATCTGGTCAATTAAAAGAAAAATACGCCGATAAAACAAAAG
AAGAATTGCACGAAATCAATGAAACTGCTACTATCGCAGGCCGTTTGATGACTAAGCGTGGTAAAGGTAAAGTTGGCTTT
GCTCACATCCAAGATCGCGATGGTCAAATCCAAATCTATGTGCGTAAAGATGCTGTCGGTGAAGAAAACTACGAAATCTT
CAAGAAAGCTGACCTTGGTGACTTCCTCGGTGTCGAAGGTGAAGTTATGCGTACAGATATGGGAGAACTTTCTATCAAGG
CTACTCATATCACGCACTTGTCTAAAGCCCTTCGTCCATTGCCTGAGAAATTCCACGGACTTTCAGACATTGAAACGATT
TACCGTAAACGTTACCTCGATTTGATTTCTAACCGTGAAAGCTTTGACCGCTTTGTCACACGTTCAAAAATCATTTCTGA
AATCCGTCGCTACCTCGATGCTCAAGGTTTCCTTGAAGTCGAAACACCAGTGCTTCACAATGAAGCTGGGGGTGCGGCTG
CCAAACCATTTATTACACACCACAATGCTCAAAATATTGATATGGTGCTTCGTATAGCTCTAGAACTTCATCTCAAACGT
CTCATTGTTGGTGGTATGGAACGCGTCTATGAGATTGGCCGTATCTTCCGTAACGAAGGAATGGATGCAACTCATAATCC
TGAATTTACTATGATTGAGGTTTACCAAGCCTATGCTGATTTCCATGATATTATGGATTTAACAGAAGGTATTATCCAGC
ATGCTGCAAAAGCTGTCAAAGGAGATGGGCCTGTCAACTACCAAGGAACAGAAATCAAAATCAACGAACCATTCAAACGC
ATCCATATGGTTGATGCCATCAAGGAAATCACTGGCGTTGACTTCTGGCAAGACATGACCTTTGAAGAAGCTGTAGCACT
TGCAAACGAAAAACATGTACCAGTTGAAAAACACTACACAGAAGTGGGACAAATTATCAATGCCTTCTTCGAAGAATTTG
TTGAAGAAACCTTGACGCAACCAACTTTTGTTTATGGTCACCCAGTAGCAGTGTCACCTTTGGCTAAGAAAAATCCAGAA
GACCCACGCTTCACGGATCGTTTTGAGCTCTTCATTATGACCAAAGAATACGGAAATGCCTATTCTGAGTTGAATGATCC
AATCGATCAATTGTCACGTTTCGAAGCACAAGCTGCTGCTAAAGAACTCGGTGACGACGAAGCAACAGGCATCGACTACG
ACTACGTTGAAGCTCTCGAATACGGTATGCCACCAACAGGTGGACTCGGAATCGGTATCGACCGTCTCTGCATGCTTCTT
ACTGACACAACAACCATCCGTGATGTCTTGTTGTTCCCAACGATGAAATAA

Protein sequence :
MPNQHMEELNDQQIVRREKMAALAEQGIDPFGKRFERTATSGQLKEKYADKTKEELHEINETATIAGRLMTKRGKGKVGF
AHIQDRDGQIQIYVRKDAVGEENYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLSDIETI
YRKRYLDLISNRESFDRFVTRSKIISEIRRYLDAQGFLEVETPVLHNEAGGAAAKPFITHHNAQNIDMVLRIALELHLKR
LIVGGMERVYEIGRIFRNEGMDATHNPEFTMIEVYQAYADFHDIMDLTEGIIQHAAKAVKGDGPVNYQGTEIKINEPFKR
IHMVDAIKEITGVDFWQDMTFEEAVALANEKHVPVEKHYTEVGQIINAFFEEFVEETLTQPTFVYGHPVAVSPLAKKNPE
DPRFTDRFELFIMTKEYGNAYSELNDPIDQLSRFEAQAAAKELGDDEATGIDYDYVEALEYGMPPTGGLGIGIDRLCMLL
TDTTTIRDVLLFPTMK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 1e-107 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_820185.1 lysyl-tRNA synthetase VFG1668 Protein 6e-108 47