Gene Information

Name : thyA (LEUM_0458)
Accession : YP_817947.1
Strain : Leuconostoc mesenteroides ATCC 8293
Genome accession: NC_008531
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 420919 - 421887 bp
Length : 969 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTCTCAAAATGAACAACAATATCTCGACCTCGCACAAAAGATTCTTGATGAAGGATCACATAAAGGAGACCGCACTGG
TACTGGAACACGTTCATTGTTCGGTACACAAATGCGATTTAACCTGGCTGAAGGATTCCCCCTTTTAACTACCAAAAAGG
TTTTCTTTGGTTTGATTAAAAGTGAACTTTTATGGTTCTTAAGAGGAGATAATAATATCCGATTCTTACTTGAACACAAT
AATCATATCTGGGATGAATGGGCGTTTAAAAAGTGGATTGAATCTGATAAATATACCGGTCCCGATATGACTAATTTTGG
TCTTCGTTCACAAACTGATGAAAATTTTGCCAAAATATACAAAGAACAAAAAGACATTTTCGTTAACAACATTCTCAATG
ATGACGAATTCAAGGAAGAATTTGGTTATATTGGAAATGTTTATGGAAAATTGTGGCGCAGCTGGGAAACAAATAGTCTG
ACCGCCGGTGATGAAACCGTTGATCAGGTCGCCAGACTTATTGATCAAATTAAGGAAACACCGAATTCACGTCGCCTCAT
TTTAACAGCTTGGAATGCTGAGACCACACCGCAAGCGCCCTTACCTTCTTGTCACGTACTTAGTCAGTTTTATGTTGCGG
ACGGTAAACTCAGTTTGCAAATGTATCAACGCTCTGGTGACTTTTTCCTTGGTGTTCCATTCAATATTGCCAGCTATTCA
CTGTTGCTACACATGGTGGCAGCTCAAACTGGCTACGAAGTTGGTGAATTTATTCATACCATTGGTGACACGCATATCTA
CAATAATCATGTTGATCAAATAACTGAACAATTGTCACGGCCTATGCACAAATTACCAAAACTATGGCTAAATCCGGAAG
TTAAATCATTGTTTGATTATACGATGGATGACATCAAAATATTAGATTACGATAGTGAACCGGCCATTAAAGCGCCCGTA
GCTGTCTAA

Protein sequence :
MSQNEQQYLDLAQKILDEGSHKGDRTGTGTRSLFGTQMRFNLAEGFPLLTTKKVFFGLIKSELLWFLRGDNNIRFLLEHN
NHIWDEWAFKKWIESDKYTGPDMTNFGLRSQTDENFAKIYKEQKDIFVNNILNDDEFKEEFGYIGNVYGKLWRSWETNSL
TAGDETVDQVARLIDQIKETPNSRRLILTAWNAETTPQAPLPSCHVLSQFYVADGKLSLQMYQRSGDFFLGVPFNIASYS
LLLHMVAAQTGYEVGEFIHTIGDTHIYNNHVDQITEQLSRPMHKLPKLWLNPEVKSLFDYTMDDIKILDYDSEPAIKAPV
AV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 5e-84 55