Gene Information

Name : thyA (LGAS_0830)
Accession : YP_814659.1
Strain : Lactobacillus gasseri ATCC 33323
Genome accession: NC_008530
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 817077 - 818033 bp
Length : 957 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGCAACTTTAGAGCAACCATACTTGGATTTACTAAATAAAATTATGATTGAAGGTCATGATAAGGAAGATAGAACTGG
CACGGGGACAAGAAGTATATTTGGAGCTCAAATGCGGTTTAATCTGAGTGAGGGTTTTCCTATTTTAACTACTAAACGAG
TTCCTTTTGGTCTTATTAAAAGTGAATTGTTGTGGTTTTTAAGAGGAGATACTAATATTCGGTTTCTATTAGAACACAAT
AATCATATTTGGGATGAATGGGCGTTCAAAAACTGGGTTGAAAGTGATGAATATCATGGCCCTGATATGACTAATTTTGG
ACTCAGAAGTCAAGAAGACGCCAAATTTAAGCAAGTCTATCAAGAAGAGATGAAGAAATTTGATGAGCGAATCTTAGCTG
ACCGGGATTTCGCAGTCAAATTTGGTAATCTTGGAGATGTTTATGGCGCTCAATGGCGTCACTGGCAAAAGCGAGAGGGT
GGTTTTATTGATCAAATTCAAAATGTGATTGATCAAATTAAAAAGACGCCATATTCAAGAAGATTGATTGTTAGTGCCTG
GAATCCAGAAGATGTACCAAATTCAGCACTCCCACCTTGTCATGTTTTATTTCAATTTTATGTTAATGATGGTCGTTTAA
GCGTTCAGCTTTATCAGCGATCAGGAGATATGTTTTTAGGAGTTCCCTTTAATATTGCGAGCTATTCTTTACTAGTTAAT
TTAATTGCTCAAGAAACTGGTCTTAAACCAGGTGAATTTATTCATACTTTAGGGGATGCGCATATTTATCGAAACCATTT
TGATCAAGTAAAAGAATTATTGACTAGAAAACCATATGACTCGCCAAAGCTTTGGCTAAATCCTGATAAGAAAAAGATTG
AAGACTTTGAAATGTCAGATATTAAACTCGTTGACTATAAGCATCATGGTACTATTAAAGCTCCCGTAGCTGTTTAG

Protein sequence :
MATLEQPYLDLLNKIMIEGHDKEDRTGTGTRSIFGAQMRFNLSEGFPILTTKRVPFGLIKSELLWFLRGDTNIRFLLEHN
NHIWDEWAFKNWVESDEYHGPDMTNFGLRSQEDAKFKQVYQEEMKKFDERILADRDFAVKFGNLGDVYGAQWRHWQKREG
GFIDQIQNVIDQIKKTPYSRRLIVSAWNPEDVPNSALPPCHVLFQFYVNDGRLSVQLYQRSGDMFLGVPFNIASYSLLVN
LIAQETGLKPGEFIHTLGDAHIYRNHFDQVKELLTRKPYDSPKLWLNPDKKKIEDFEMSDIKLVDYKHHGTIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-94 58