Gene Information

Name : thyA (LBUL_0720)
Accession : YP_812781.1
Strain : Lactobacillus delbrueckii ATCC BAA-365
Genome accession: NC_008529
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 672441 - 673397 bp
Length : 957 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGCAAATCAAGACCAAGCATATTTAGATTTACTGAAAAAGATCATGACGGAAGGCAATGACAAAAATGACCGGACCGG
GACGGGGACCAGAAGCCTCTTTGGGGCCCAGATGCGCTTTGACTTAAGCCAGGGCTTCCCGATCTTGACGACCAAGAGGG
TGCCTTTCGGCCTGATCAAGAGCGAACTTTTGTGGTTCTTGCGGGGGGACACCAACATCCGTTTCTTGCTTGAACATAAA
AACCACATTTGGGACGAATGGGCCTTTAAAAATTGGGTGACCAGCCCGGAATACCAGGGCCCGGACATGACTGATTTTGG
CCTTAGGAGTCAAAAGGACCCAGGGTTTAAGGCAGTCTATGACGAAGAAATGCAAAAGTTCTGCCAGCGGATTTTGGATG
ATGAAGCTTTTGCCCAAAAATACGGCAACCTGGGCGACGTCTATGGGGCCCAGTGGCGGCACTGGGGTAAGCGGGACGGC
GGCTTTATCGACCAGATCGCGGACGTGATTGAGCAGATCAAGACCAATCCCGACTCCCGCCGCTTGATCGTAACGGCATG
GAACCCGGAAGACGTTCCTTCCAGCGCCCTGCCGCCGTGCCATGTCCTCTTCCAGTTTTACGTGGCTGACGGCAAGCTCA
GCTTGCAGCTTTACCAGCGCTCAGGCGACATGTTCTTAGGCGTGCCCTTCAACATTGCCAGCTACTCTTTGCTCTTGTCC
TTGATTGCCCGGGAGACCGGCCTGGAAGTGGGCGAGTTTGTGCATACTATTGGGGATGCCCACATTTACAAGAACCACTT
TGCCCAAGTGGAAGAGCAGCTGAAAAGAAAGCCGTTTGACGCGCCAACTTTGTGGCTGAATCCAGGGAAGAAAAAAGTAG
CTGATTTTGAAATGGCTGATATTAAATTGGTCAACTACCAGCACGGGTCTACAATCAAGGCCCCGGTTGCCGTTTAG

Protein sequence :
MANQDQAYLDLLKKIMTEGNDKNDRTGTGTRSLFGAQMRFDLSQGFPILTTKRVPFGLIKSELLWFLRGDTNIRFLLEHK
NHIWDEWAFKNWVTSPEYQGPDMTDFGLRSQKDPGFKAVYDEEMQKFCQRILDDEAFAQKYGNLGDVYGAQWRHWGKRDG
GFIDQIADVIEQIKTNPDSRRLIVTAWNPEDVPSSALPPCHVLFQFYVADGKLSLQLYQRSGDMFLGVPFNIASYSLLLS
LIARETGLEVGEFVHTIGDAHIYKNHFAQVEEQLKRKPFDAPTLWLNPGKKKVADFEMADIKLVNYQHGSTIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-90 60