Gene Information

Name : LACR_0831 (LACR_0831)
Accession : YP_808806.1
Strain : Lactococcus lactis SK11
Genome accession: NC_008527
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 773421 - 774563 bp
Length : 1143 bp
Strand : +
Note : catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine

DNA sequence :
ATGACAAGTTTAAAAACAAAAGTAATTCACGGTGGAATTTCAACAGATAGAACAACAGGAGCTGTTTCTGTTCCAATTTA
TCAAACATCAACTTATAAACAAAATGGACTTGGAAAACCTAAAGAATATGAATATTCACGTTCAGGTAATCCGACACGAC
ATGCTTTGGAAGAATTAATTGCAGATTTAGAGGGTGGGGTTCAAGGTTTTGCTTTTAGTTCAGGCTTGGCTGGAATTCAC
GCGGTACTATCTTTATTTTCTGCGGGCGATCATATCATCTTAGCTGATGATGTTTATGGCGGAACTTTTCGATTGATGGA
CAAGGTGCTGACAAAGACAGGAATAATCTATGATTTAGTAGATTTGAGCAATCTTGAAGATTTAAAGGCAGCTTTTAAAG
CAGAAACCAAAGCAGTCTACTTTGAAACTCCCTCAAATCCCCTGCTAAAAGTCTTGGATATCAAAGAAATTTCAAGCATT
GCTAAAGCTCATAATGCTCTAACATTAGTTGATAATACCTTTGCGACGCCTTATTTACAACAACCAATCGCTCTAGGAGC
GGATATTGTCTTGCATTCTGCAACGAAATATTTAGGAGGACACTCAGATGTAGTGGCTGGTTTGGTAACGACAAATTCAA
ATGAACTCGCTAGTGAAATTGGCTTTTTACAAAATTCTATTGGAGCGGTTCTTGGTCCACAAGATAGCTGGTTAGTCCAA
AGAGGAATCAAAACACTTGCACTCCGGATGGAGGCCCATTCAGCAAATGCTCAAAAAATTGCTGAGTTTTTAGAAGCATC
ACAAGCTGTTTCAAAAGTCTATTATCCAGGTCTCGTCAATCATGAAGGACATGAGATTGCTAAAAAACAAATGACTGCTT
TTGGTGGAATGATTTCATTTGAATTGACTGACGAAAATGCGGTTAAAAATTTTGTTGAAAACTTGCGCTATTTTACACTA
GCCGAATCACTCGGCGGAGTCGAATCTTTGATTGAAGTGCCAGCAGTAATGACTCATGCCTCAATTCCTAAAGAACTTCG
GGAAGAAATTGGGATAAAAGATGGATTGATTCGCTTATCAGTCGGTGTTGAAGCTCTTGAAGATTTACTGACGGACCTTA
AAGAAGCACTCGAAAAAGAATAA

Protein sequence :
MTSLKTKVIHGGISTDRTTGAVSVPIYQTSTYKQNGLGKPKEYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIH
AVLSLFSAGDHIILADDVYGGTFRLMDKVLTKTGIIYDLVDLSNLEDLKAAFKAETKAVYFETPSNPLLKVLDIKEISSI
AKAHNALTLVDNTFATPYLQQPIALGADIVLHSATKYLGGHSDVVAGLVTTNSNELASEIGFLQNSIGAVLGPQDSWLVQ
RGIKTLALRMEAHSANAQKIAEFLEASQAVSKVYYPGLVNHEGHEIAKKQMTAFGGMISFELTDENAVKNFVENLRYFTL
AESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEALEDLLTDLKEALEKE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-96 55
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-97 55
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 5e-73 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
LACR_0831 YP_808806.1 cystathionine gamma-synthase BAC0207 Protein 1e-70 43