Gene Information

Name : guaA (LSEI_1979)
Accession : YP_807179.1
Strain : Lactobacillus casei ATCC 334
Genome accession: NC_008526
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1950811 - 1952364 bp
Length : 1554 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGCAAATGACCAGAACAAGGATTACGACAAGATCATCGTCCTCGATTATGGCAGTCAGTATAATCAATTGATCACCCG
GCGAATCCGGGAATTTGGGATTTACTCTGAATTAAAGCCTCATACGATCACGGCAGCGGAAGTCAAGAAGATTGCGCCTA
AAGGCATTATCTTCTCAGGCGGCCCTAACAGTGTGTATGACGAAGGCGCGTTAGGTGTTGATGAGGATCTTTTCAAGCTC
GGCATTCCGATTCTGGGTGTCTGTTATGGCATGCAGCTGATGGCACAACGGCTCGGTGGGGATGTTGAACCGGCTGATAA
CCGTGAATACGGCAAAGCGGACATTGAAGTCACCGATGACAGCGCCAAGCTTTTCCGCGATTTGCCAAAAGATCAAACCG
TCTGGATGAGCCACGGCGACCTCGTGACACGCGTACCAGAAGGCTTCCGGCGAACTGCAACCAGCATCAACTGCCCAATC
AGTGCCATGGATGACGATGATCGTAAATTCTACGGTATCCAATTCCATGCTGAAGTTCAAAATACGCAATATGGCCATGA
AATCCTCCACCATTTTGCCTTCGACATCTGCAAGGCTGAAGCCAACTGGAGCATGGACGACTTCATCACCAAACAAATCG
ACAAGATTCGGGCAGAAGTCGGCGACAAGCGCGTTCTCCTCGGTCTTTCCGGCGGAGTGGATTCATCCGTAGTCGGCGTG
CTCCTGCACAAAGCCATCGGCACCCAGCTGACCAGTATTTTTGTTGATCACGGCTTGTTGCGTAAAGGCGAAGCTGATCA
AGTCATGGAAAGCCTCAAAGGCAAGTTCGGCCTGAACATCATCAAGGTCAACGCCAAAGATCGTTTCCTCGGCGACCTCA
AAGGGGTTACTGATCCTGAAAAGAAACGTAAAATCATCGGTCGCGACTTCATCGAAGTTTTCAATGAAGAAGCAGCCAAG
CTCAACGGCATCGATTTCTTAGCCCAAGGCACGCTCTACACCGATGTGGTTGAATCCGGTACCGACACCGCTCAGACCAT
TAAGTCTCACCACAACGTTGGCGGCCTGCCAGAAGACCTCAAGTTCAAGCTAATCGAACCGCTGAACAAACTCTTCAAGG
ATGAAGTCCGTGAACTCGGCGAAAAACTCGGCATGCCCCACGCCCTCGTCTGGCGCCAACCATTCCCAGGCCCAGGCCTC
GGCATCCGCGTCATCGGCGAAGTTACCGAAGATAAACTCGAAATCGTGCGCGATTCCGATTATATCCTCCGTGAAGAAAT
CGCTAAGCATGGCTTGGACAAAGACATTTGGCAATACTTTACCGTCTTACCAGGCTTCCGATCCGTTGGTGTCATGGGCG
ATGGCCGAACCTACGACTACACCATCGGCATCCGCGCCATCACATCAATTGACGGCATGACCGCCGACTTTGCCCGGATC
AACTGGGATGTCTTACAGGAGATCTCAAGCCGGATTGTGAATGAAGTTAAGAACGTTAATCGGGTGGTTTATGATATTAC
TTCCAAGCCGCCGGCAACGATTGAGTGGGAATGA

Protein sequence :
MANDQNKDYDKIIVLDYGSQYNQLITRRIREFGIYSELKPHTITAAEVKKIAPKGIIFSGGPNSVYDEGALGVDEDLFKL
GIPILGVCYGMQLMAQRLGGDVEPADNREYGKADIEVTDDSAKLFRDLPKDQTVWMSHGDLVTRVPEGFRRTATSINCPI
SAMDDDDRKFYGIQFHAEVQNTQYGHEILHHFAFDICKAEANWSMDDFITKQIDKIRAEVGDKRVLLGLSGGVDSSVVGV
LLHKAIGTQLTSIFVDHGLLRKGEADQVMESLKGKFGLNIIKVNAKDRFLGDLKGVTDPEKKRKIIGRDFIEVFNEEAAK
LNGIDFLAQGTLYTDVVESGTDTAQTIKSHHNVGGLPEDLKFKLIEPLNKLFKDEVRELGEKLGMPHALVWRQPFPGPGL
GIRVIGEVTEDKLEIVRDSDYILREEIAKHGLDKDIWQYFTVLPGFRSVGVMGDGRTYDYTIGIRAITSIDGMTADFARI
NWDVLQEISSRIVNEVKNVNRVVYDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-168 67
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-169 67
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-169 67
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-124 50