Gene Information

Name : thyA (LSEI_1387)
Accession : YP_806607.1
Strain : Lactobacillus casei ATCC 334
Genome accession: NC_008526
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1376333 - 1377283 bp
Length : 951 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTTAGAGCAGCCATATCTTGATCTTGCCCAAAAAGTATTAGATGAAGGCCATTTCAAGCCTGATCGTACGCATACTGG
CACGTACAGTATTTTTGGTCACCAAATGCGGTTTGACCTTAGCAAAGGGTTTCCTTTACTAACAACCAAAAAGGTGCCCT
TTGGTCTCATTAAAAGCGAGTTACTTTGGTTCTTGCGTGGCGACACCAACATTCGTTTCCTATTGCAGCATAAAAATCAC
ATCTGGGATGAATGGGCCTTTGAGAAGTGGGTTGCCAGCCCCGATTATCATGGTCCGGATATGACCGATTTTGGTCATCG
CAGCCAGAAAGATCCTGAATTTGCCGCCAGTTATCGTGAACAGATGGCCAAGTTTGACGAACGTATTCTCACTGACGAGT
CATTTGCAGCTAAATACGGTGATTTAGGATTGGTTTATGGCTCGCAATGGCGGGCGTGGCATACCAGTCGTGGTGACACC
ATCGACCAGCTGGGGGATGTGATTGAGCAGATTAAGACGCATCCATACTCGCGACGCTTGATCGTATCCGCTTGGAATCC
AGAAGATGTGCCAACCATGGCGTTACCGCCTTGTCACACCCTCTTCCAGTTTTATGTCAATGATGGCAAACTTTCCTTGC
AACTGTATCAGCGTTCTGCGGACATTTTCCTTGGCGTGCCGTTTAATATTGCCTCATATGCCTTGCTGACCCATCTTGTT
GCCCATGAATGCGGGTTGCAAGTTGGGGACTTCATTCATACATTTGGCGATGCTCATTTGTATGTCAATCATTTGGACCA
AATCAAAGAACAATTAACGCGGACGCCACGGCAGGCGCCAACCTTGGTCTTGAATCCAGATAAACACGATATTTTTGATT
TTGATATGCAAGATATTAAATTGTTGAATTATGATCCTTATCCGGCCATTAAAGCACCAGTTGCCGTTTAA

Protein sequence :
MLEQPYLDLAQKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLRGDTNIRFLLQHKNH
IWDEWAFEKWVASPDYHGPDMTDFGHRSQKDPEFAASYREQMAKFDERILTDESFAAKYGDLGLVYGSQWRAWHTSRGDT
IDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLFQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLQVGDFIHTFGDAHLYVNHLDQIKEQLTRTPRQAPTLVLNPDKHDIFDFDMQDIKLLNYDPYPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 3e-105 66