Gene Information

Name : guaA (PEPE_0412)
Accession : YP_803950.1
Strain : Pediococcus pentosaceus ATCC 25745
Genome accession: NC_008525
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 459253 - 460806 bp
Length : 1554 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGGCGAACGCAGATTTATCAAATTTTGATAAAATCATTGTTTTGGATTTCGGTAGTCAATACAACCAATTGATTACACG
TAGAATCCGTGAATTCGGTATTTACTCTGAGCTTCTTTCTCATAAGATTACTGCTGAAGAAATCAAAAAGATTAATCCTA
AAGGAATTATCTTCTCTGGTGGACCTAACAGTGTTTATGATAAAGATGCCTTTCGAATTGACCCAGAAATTTATAAGTTA
GGTATTCCAATTTTAGGTATTTGTTACGGAATGCAATTAATGACTTATAACTTAGGCGGACGAGTTGAACCAGCTGATAA
CCGTGAATACGGTCATGCTGATATTGATGTGACTGATGATCAAGCGGTTATGTTTAAAGAGCTTCCTGCTAAACAAACAG
TTTGGATGAGCCATGGTGATTTGGTTCGTGAAGTCCCTGAAGGATTTAAGACCGTTGCAACTAGCGCAAACTGTCCGATT
GCCTCAATGGCTGATGATGCTCGTAAGTTCTACGGGGTTCAATTCCATGCTGAAGTACGTAATACTCAATATGGTAACGA
AATTCTCCGGCACTTTGCATTTGACGTTTGTGAAGCTAAAGCTAACTGGTCCATGAACGACTTTATCGACATGCAAGTAC
AACAAATCCGTGAAACTGTGGGAGACCGTAAAGTATTGCTTGGTCTTTCTGGTGGAGTGGATTCTAGCGTGGTTGGGGTA
TTACTCAATAAAGCAATCGGTGACCAATTAGTATGTATCTTCGTAGATCACGGTTTACTCCGCAAGGGCGAAGCAAAGCA
AGTTATGGATAGTCTAGAAGGTAAGTTTGGTTTGAACATTATCAAAGTGGATGCTCAAGATCGCTTCTTGAGTAAGCTTG
CTGGTGTTTCAGAACCTGAACAAAAACGTAAGATTATTGGTAACGAGTTTATTCAAGTATTTAATGATGAAGCACAAAAA
CTTAAAGGAATTGACTTCCTAGCTCAAGGTACGCTTTACACTGATGTAATCGAAAGTGGAACAGATACTGCTCAAACGAT
TAAGTCACATCATAATGTGGGTGGACTTCCAGAAGACATGCACTTTGAATTGATTGAACCACTTCGTACTTTATTTAAAG
ACGAAGCTCGTGACCTTGGTGAAAAATTGGGAATGCCAGAAGATCTCGTTTGGCGTCAACCATTCCCAGGTCCTGGTTTG
GGAATTCGTGTAATCGGTGAAATCACCGAAGACAAACTTCAAATTGTGCGTGACAGTGACTTGATTCTTCGCGAAGAAAT
CAAGAAGGCTGGTCTCGACCGTGATATCTGGCAATACTTTACTGTTTTACCTGGTATCCGTAGTGTTGGTGTTATGGGTG
ACGGCCGCACTTACGATTACACAGTAGGTATCCGGGCTGTTAACTCAATCGACGGTATGACTGCCGACTTTGCTCGTATC
CCATGGGATGTCTTGCAAAAGATTTCGGTACGTATCGTAAATGAAGTGGACCATGTTAACCGCATCGTCTATGACATTAC
TTCTAAGCCACCGGCAACTGTGGAATGGGAATAA

Protein sequence :
MANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSGGPNSVYDKDAFRIDPEIYKL
GIPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDDQAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPI
ASMADDARKFYGVQFHAEVRNTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGV
LLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPEQKRKIIGNEFIQVFNDEAQK
LKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGL
GIRVIGEITEDKLQIVRDSDLILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARI
PWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-176 72
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-177 72
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-177 72
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-126 50