Gene Information

Name : guaA (LBJ_1923)
Accession : YP_801199.1
Strain :
Genome accession: NC_008510
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2267115 - 2268926 bp
Length : 1812 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGAAGTCCGGAAGAAAATTGCCGTGGTTGATTTTGGTGGGCAATATGCTCACTTGATAGCATCCAGAATTCGAAGATT
AGGCGCTTATACGGAAATTCTTTCTAACGAAGAACCTCTTTCCAATTATCAAAAATATACGGGTATTATTCTTTCCGGCG
GGCCGGAAAGTGTTTACGAACCCGATTCTCCAACGATTACAACTCGGATTTTCGAACTAGGAATTCCGGTCCTCGGAATT
TGTTATGGCCATCAGTTGATTATGAAGCTTCTCGGCGGAGTTGTAAAACGTTCCGGAACGGGAGAATACGGTCCTACTTC
TTTACAAATTCATGATTCCGGCGAAAACTTTCTTTTGAAGAATTTTATAGGAGGGGAACGGGTTTGGATGAATCACGCCG
ACGAAGTCGTAAAACTTCCGGAGGGTTTTACAAGGACCGCTTCTTCGAAAGATTGTGGTTATGCGGTTGTGGAGAATACT
TCCAAGAAAATTTTCGGAATTCAATTTCATGCGGAAGTAAGTCATAGCGAAAATGGTTCTCTTCTTCTTGATAATTTTAT
TCAAATTTGCGGAGCTTCTAGAACCTGGGGAATCGATCGGTTCTTAAAAAAAAAGATCGAAGAGATTCAAAAAACCGTAA
AGCCGGAACAAAAGATTTTTATGCTCGTTTCGGGTGGAGTGGATTCCACCGTTTCTTATCTTCTTCTGTGCAAAGCTCTC
GGTGCGGAAAGAGTTTTCGGATTTTTAGTCGACACCGGTTTTATGAGAAAAGGAGAAGTTCTTTATCTTCAAGAAAGACT
GGCTCTTCAGGATATCCGTCTAACGGTAAGAGACGAATCGAATCTTTTTTATGAAAGTTTAAAAGGGAAATCCGATCCCG
AAGAAAAAAGAAAAATCGTAGGAAACTTATTTCTAGAAGTTAGGGACCGCGCCATAAAAGATTTAGATCTGGAACACGGG
GATTGGCTCCTCGGTCAAGGTACTATCTATCCGGACACGATTGAATCCGGTGGGACGAAACATTCTCATACTATTAAAAC
GCATCATAATCGAGTCGAAGCGATTCAAAAATTGATCGAAGAGGGAAAGATCATTGAACCGATCCGAGATCTTTATAAAG
ACGAGGTCAGAGATCTGGGAGTTCTTCTTGGGTTGGAAGCGGAATGGGTAGGCCGCCATCCGTTTCCAGGACCCGGACTT
GTGGTGCGCATGTTAGCGGTTGAAAAAAAAGGAACGAGCGAGGACCAAAAGGAAATCGATTCTTATCTTGCGACTCAAGG
GGGATTATCCGGCAAAATCCTTCCCGTCGCCAGCGTAGGCGTTAAAGGAGATCGAAGATCCTATGCAAACTGTGTAGTGT
TAAGCGACATCGGAACGAATTGGAAAACTTTGGATCGGGTCGCTACACATCTTTCCAATCAGTTTTCCTTTATTAATCGT
GTAGTTCTCTTACCTTTCGAGACCGACGTCAAAAAATTGAATTTTCAATTTACTGGAATGCAGTTGGATAAGAATTATTC
CGATTTGCTTCGGGAAGCGGATTATGCGGTCGAGTCCGTGATTCGCAAAGCCGGTCTTTACGATAAGATTTGGCAGATGC
CCGTCGTTCTTTTGCCCATCGGGGAAAAGAAGAATGAAAAGAGTATCGTTCTTCGTCCGGTTGAATCTCAGGAGGCGATG
ACGGCTAACTTTTTCCCGATGGAACGCTTTTTGTTGCAGGAAATCAAAGACGTGGTTTCCAAGATCAGCGGGATTCGTTA
CGTATTTTTCGATCTTACGAACAAGCCGCCGGGTACGATCGAGTGGGAATAA

Protein sequence :
MEVRKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSNYQKYTGIILSGGPESVYEPDSPTITTRIFELGIPVLGI
CYGHQLIMKLLGGVVKRSGTGEYGPTSLQIHDSGENFLLKNFIGGERVWMNHADEVVKLPEGFTRTASSKDCGYAVVENT
SKKIFGIQFHAEVSHSENGSLLLDNFIQICGASRTWGIDRFLKKKIEEIQKTVKPEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVFGFLVDTGFMRKGEVLYLQERLALQDIRLTVRDESNLFYESLKGKSDPEEKRKIVGNLFLEVRDRAIKDLDLEHG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEEGKIIEPIRDLYKDEVRDLGVLLGLEAEWVGRHPFPGPGL
VVRMLAVEKKGTSEDQKEIDSYLATQGGLSGKILPVASVGVKGDRRSYANCVVLSDIGTNWKTLDRVATHLSNQFSFINR
VVLLPFETDVKKLNFQFTGMQLDKNYSDLLREADYAVESVIRKAGLYDKIWQMPVVLLPIGEKKNEKSIVLRPVESQEAM
TANFFPMERFLLQEIKDVVSKISGIRYVFFDLTNKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-75 41
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-75 41
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-75 41