Gene Information

Name : guaA (LVIS_1759)
Accession : YP_795857.1
Strain : Lactobacillus brevis ATCC 367
Genome accession: NC_008497
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1717606 - 1719171 bp
Length : 1566 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAATGGCTTGGCAAACGTTGATATGTCTAAATTCGACAAGATCATCGTCTTAGACTTTGGGAGTCAATACAACCAATT
GATCACCCGCCGGATTCGTGACCTCGGAGTTTACTCCGAATTAAAGGCCCATACGATGACTGCGGCTGAGATTAAGGCTT
GGGGCCCCAAGGGAATTATCTTCTCTGGTGGACCAAATAGTGTCTACGACAGTAGTGCATTTAATGTGGACCCAGAGATT
TTTAACCTCGGTATTCCAATTTTAGGAATTTGTTACGGGATGCAACTGATGGCCCACAGTTTGACGGGTGGCAAGGTTGA
ATCCGCTGATAACCGAGAATACGGTCGGGCCGATATTACGGTTCTGAGCGACGACGCAAAGCTATTCCACGACACCCCTA
AGGAACAAACGGTGTGGATGAGCCATGGGGACTTAGTCACTCAAGTGCCTGATGGTTTTGAACGGGTAGCAACCAGTGAA
AACTGTCCAATTTCAGCGATGCAGGATACGACCCGTAATTTCTATGGGATTCAATTCCATGCGGAAGTCCGGAACACAGA
ATACGGTAACGATATCTTAAAGCACTTTGCTTTTGATGTCTGCCAAGCACAGGCTAACTGGTCAATGGATGATTTCATTG
ATTTACAAATTGCTCAAATTCGGGAAACCGTTGGCGACAAGAAGGTCCTGTTGGGTCTGTCTGGTGGGGTTGATTCATCC
GTTGTGGGCGTGTTATTGCATAAAGCAATCGGCTCACAATTGACCAGTATCTTCGTCGATCATGGTCTATTACGTAAGGG
TGAAGCCAAGCAAGTAATGGACAGCCTAGAAGGTAAATTTGGGTTGAACATCGTGCAGGTCAACGCGCAAGATCGCTTCT
TGAGTAAGTTGGCAGGCGTTACGGAACCCGAAAAGAAACGTAAGATTATTGGAAATGAGTTTATTCAAGTCTTCAATGAT
GAGGCCCAGAAGCTGGATGGTATCGACTTCTTAGCCCAAGGAACGCTGTACACTGACGTGATTGAAAGTGGGACGGATAC
GGCCCAAACAATCAAGTCACACCATAACGTTGGTGGCTTGCCAGAAGATATGCATTTCCAATTGATTGAACCCTTACGTT
CGCTGTTCAAGGATGAAGCCCGTGAATTGGGTGAAAAGCTGGGAATGCCAAGCGAGTTAGTGTGGCGGCAACCATTTCCT
GGTCCTGGTTTAGGGATTCGGGTATTGGGTGAAATTACACCAGAAAAGCTCCAAATTGTCCGCGATAGCGATTTGATTCT
CCGTGAGGAAATCAAGAAGGCCGGTCTCGACCGAGACATTTGGCAATACTTTACGGTGCTGCCCAACATCAAGAGTGTCG
GGGTAATGGGCGATGGCCGGACGTATGATTACGCCGTGGGTATTCGCGCTGTCACTTCGATTGATGGTATGACGGCTGAC
TTCGCGCATATTCCATGGGATGTCTTGCAAGATATTTCTGTGCGGATTGTTAATGAAGTGGAACATGTTAACCGCATCTT
ATATGATGTGACGAGTAAGCCGCCTTCGACTATTGAGTGGGAATAA

Protein sequence :
MNGLANVDMSKFDKIIVLDFGSQYNQLITRRIRDLGVYSELKAHTMTAAEIKAWGPKGIIFSGGPNSVYDSSAFNVDPEI
FNLGIPILGICYGMQLMAHSLTGGKVESADNREYGRADITVLSDDAKLFHDTPKEQTVWMSHGDLVTQVPDGFERVATSE
NCPISAMQDTTRNFYGIQFHAEVRNTEYGNDILKHFAFDVCQAQANWSMDDFIDLQIAQIRETVGDKKVLLGLSGGVDSS
VVGVLLHKAIGSQLTSIFVDHGLLRKGEAKQVMDSLEGKFGLNIVQVNAQDRFLSKLAGVTEPEKKRKIIGNEFIQVFND
EAQKLDGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFQLIEPLRSLFKDEARELGEKLGMPSELVWRQPFP
GPGLGIRVLGEITPEKLQIVRDSDLILREEIKKAGLDRDIWQYFTVLPNIKSVGVMGDGRTYDYAVGIRAVTSIDGMTAD
FAHIPWDVLQDISVRIVNEVEHVNRILYDVTSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-168 69
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-168 69
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-168 69
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-121 50