Gene Information

Name : leuS (PA14_12230)
Accession : YP_789131.1
Strain : Pseudomonas aeruginosa UCBPP-PA14
Genome accession: NC_008463
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 1055410 - 1058031 bp
Length : 2622 bp
Strand : -
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGCACGAGCAATATCAGCCACTCGAGATCGAAACCCAGGCCCAGAACTACTGGAAAGAACACCAGTCCTTCCTCGTCAG
GGAGCTACCCGACAAGGAGAAGTTCTACTGCCTGTCGATGTTCCCGTATCCGAGCGGCAAGCTGCACATGGGCCACGTGC
GCAACTACACCATCGGCGACGTGATCAGCCGCTACCACCGCATGCAGGGCCGCAACGTGCTGCAGCCGATGGGCTGGGAC
GCGTTCGGCATGCCGGCGGAAAACGCCGCGATGAAGAACAACGTCGCCCCGGCGGCCTGGACCTACGACAACATCGCCTA
CATGAAGTCGCAGTTGGACAGCCTCGGCCTGGCGATCGACTGGAGCCGCGAGGTCACCACCTGCAAGCCGGACTACTACC
GCTGGGAGCAGTGGCTGTTCACCCGCCTGTTCGAAAAAGGGGTGATCTACCGCAAGAACGGCACGGTCAATTGGGATCCG
GTCGACCAGACCGTACTCGCCAACGAGCAGGTGATCGACGGGCGCGGCTGGCGCTCCGGCGCGCTGATCGAGAAGCGCGA
GATCCCGATGTACTACTTCAAGATCACCGCCTACGCCGAGGAACTGCTGGAGAGCCTCGACAACCTGCCCGGCTGGCCGG
AGCAGGTGAAGACCATGCAGCGCAACTGGATCGGCAAGTCGCGTGGGATGGAGATCGGCTTCCCCTACGACCAGGCCTCC
ATCGGCCACGCCGGCCAACTGAAGGTGTTCACCACCCGTCCGGACACCCTGATGGGCGCCACCTACGTCGCCGTCGCCGC
CGAACACCCGCTGGCCACCCAGGCCGCGCAGAACGACCCGCAGTTGCAGGCGTTCATCGACGAATGCAAGCGCGGCGGCG
TCGCCGAGGCCGACATCGCCACCCAGGAGAAGAAAGGCATGGCCACTTCCCTGTTCGTCGAACACCCGCTGACCGGCGAC
AAGCTGCCGGTATGGGTCGCCAACTACGTGCTGATGAACTACGGCGAAGGCGCGGTGATGGCGGTGCCCGGCCATGACGA
GCGCGACTTCGAGTTCGCCAACAAGTACGGCCTGCCGATCCGCCAGGTGATCGCCAAGGTCGAGGGCGACGACGACTTCG
AGTCCAGCGTCTGGAAGGAGTGGTACGGCGCCAAGGACGAGTCCGTGCTCACCGTCAACTCCGGCAAGTACGACAACCTC
GGCTACCAGGCCGCCTTCGACGCCATCGGCGCCGACCTCGAGGCCAAGGGCCTGGGCCAGGCGCGCACCCAGTTCCGCCT
GCGCGACTGGGGCATCAGCCGCCAGCGCTACTGGGGCTGCCCGATCCCGATCATCCACTGCGAGGCTTGCGGCGACGTCC
CGGTGCCAGCCGACCAGTTGCCGGTGGTGCTGCCGGAAGACGTGGTACCGGACGGCTCCGGTTCGCCGCTGGCGAAGATG
CCGGAATTCTACGAATGCAGCTGCCCGAAATGCGGCCAGCCGGCCAAGCGCGAAACCGACACCATGGACACCTTCGTCGA
GTCGTCCTGGTATTTCGCCCGCTACGCCTGCCCGCAGTTCGAAGGCGGCATGCTGGACAGGAAGGCGGCCGACTACTGGC
TGCCGGTCGACCAGTACATCGGCGGCATCGAGCACGCCATCCTGCACCTGCTCTATGCGCGCTTCTTCCACAAGCTGATG
CGCGACGAGGGCCTGGTCGGCAGCGACGAGCCGTTCAAGAACCTGCTGACCCAGGGCATGGTGGTCGCCGATACCTACTA
CCGGACCACCGCCAACGGCGGCAAGGACTGGTTCAACCCGGCCGACGTCGAGGTCGAGCGTGACGCCAAGGCCAAGGTCG
TCGGCGCACGCCTGAAGAGCGACGGCCAGCCGGTCGAGATCGGCGGCACCGAGAAGATGTCGAAGTCGAAGAACAACGGC
GTCGACCCGCAATCGATGATCGACCAGTACGGTGCCGATACCTGCCGCCTGTTCATGATGTTCGCCTCGCCGCCGGACAT
GAGCCTGGAGTGGTCGGACGCCGGCGTCGAGGGCGCCAACCGCTTCCTCCGCCGCGTCTGGCGCCTGGCTCACGCCCATG
TCAGCGCCGGCCTCCCCGGCGCGCTGGACGTCGCCGCCCTGGACGACGCGCAGAAGCAGGTCCGCCGCGCCATCCACCTG
GCGATCAGGCAGGCCAGCCAGGATGTCGGCCAGCACCACAAGTTCAACACCGCCATCGCCGCGGTGATGACCCTGATGAA
CGTGCTGGAGAAGGCGCCGAACCAGGACGCCCAGGACCGCGCCCTGATCCAGGAAGGCCTGGAAACCGTGGTCCTGCTGC
TGGCGCCCATCACTCCGCACATCTGCCACGTGCTCTGGGGCCAGCTCGGCCATGCCGAAGCGGTGATCGATGCGCGCTGG
CCGAGCGTCGACGAGAGCGCACTGGTGCAGGACACCCTGCAACTGGTGGTGCAGGTCAACGGCAAGCTGCGCGGGCACAT
CGACGTGGCCGCCAGCGCCAGCCGCGAGGATGTCGAGGCCGCCGCGCGCGCCAACGAGAACGTGCTGCGTTTCACCGAAG
GCCTGAGCATCCGCAAGGTCATCGTGGTACCGGGCAAACTGGTCAACATCGTCGCCAACTGA

Protein sequence :
MHEQYQPLEIETQAQNYWKEHQSFLVRELPDKEKFYCLSMFPYPSGKLHMGHVRNYTIGDVISRYHRMQGRNVLQPMGWD
AFGMPAENAAMKNNVAPAAWTYDNIAYMKSQLDSLGLAIDWSREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGTVNWDP
VDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITAYAEELLESLDNLPGWPEQVKTMQRNWIGKSRGMEIGFPYDQAS
IGHAGQLKVFTTRPDTLMGATYVAVAAEHPLATQAAQNDPQLQAFIDECKRGGVAEADIATQEKKGMATSLFVEHPLTGD
KLPVWVANYVLMNYGEGAVMAVPGHDERDFEFANKYGLPIRQVIAKVEGDDDFESSVWKEWYGAKDESVLTVNSGKYDNL
GYQAAFDAIGADLEAKGLGQARTQFRLRDWGISRQRYWGCPIPIIHCEACGDVPVPADQLPVVLPEDVVPDGSGSPLAKM
PEFYECSCPKCGQPAKRETDTMDTFVESSWYFARYACPQFEGGMLDRKAADYWLPVDQYIGGIEHAILHLLYARFFHKLM
RDEGLVGSDEPFKNLLTQGMVVADTYYRTTANGGKDWFNPADVEVERDAKAKVVGARLKSDGQPVEIGGTEKMSKSKNNG
VDPQSMIDQYGADTCRLFMMFASPPDMSLEWSDAGVEGANRFLRRVWRLAHAHVSAGLPGALDVAALDDAQKQVRRAIHL
AIRQASQDVGQHHKFNTAIAAVMTLMNVLEKAPNQDAQDRALIQEGLETVVLLLAPITPHICHVLWGQLGHAEAVIDARW
PSVDESALVQDTLQLVVQVNGKLRGHIDVAASASREDVEAAARANENVLRFTEGLSIRKVIVVPGKLVNIVAN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 2e-139 41