Gene Information

Name : thyA (PA14_04480)
Accession : YP_788513.1
Strain : Pseudomonas aeruginosa UCBPP-PA14
Genome accession: NC_008463
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 398905 - 399699 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAGTACCTCGACCTGATGCGCCACGTGCGCGAGCACGGCACCTTCAAGAGCGACCGCACCGGCACCGGCACCTA
TAGCGTGTTCGGCCACCAGATGCGCTTCGACCTGGCCGCGGGCTTCCCCCTGGTGACCACCAAGAAGTGCCATCTCAAGT
CGATCGTCCACGAGCTGCTGTGGTTCCTCAAGGGCTCCACCAATATCGCCTACCTCAAGGAGCACGGCGTCTCGATCTGG
GACGAGTGGGCCGACGAGAACGGCGACCTCGGCCCGGTGTATGGCTACCAGTGGCGCTCCTGGCCGGCGCCGGACGGCCG
CCACATCGACCAGATCGCCAACCTGATGGCGATGCTGAAGAAGAATCCGGACTCGCGCCGGCTGATCGTCTCCGCCTGGA
ACCCGGCGCTGATCGACGAGATGGCCCTGCCGCCCTGCCACGCGCTGTTCCAGTTCTACGTCGCCGACGGCAAGCTCAGC
TGCCAGCTCTACCAGCGTTCGGCGGACATCTTCCTCGGCGTACCCTTCAACATCGCCAGCTACGCTTTGCTGACCCTGAT
GGTGGCGCAGGTCGCCGGCCTGCAGCCGGGCGAGTTCATCTGGACCGGCGGCGATTGCCACCTGTACGCCAACCACCTGG
AGCAGGCCGACCTGCAGTTGACCCGCGAGCCGCTGCCGTTGCCGAGCATGAAGCTGAATCCCGAGGTGAAGGATCTGTTC
GACTTCCGCTTCGAGGACTTCGAGCTGGTCGGCTACGAGGCCCATCCGCACATCAAGGCACCGGTCGCGGTCTGA

Protein sequence :
MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELLWFLKGSTNIAYLKEHGVSIW
DEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLS
CQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLF
DFRFEDFELVGYEAHPHIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 6e-81 66