Gene Information

Name : guaA (PA14_15340)
Accession : YP_789364.1
Strain : Pseudomonas aeruginosa UCBPP-PA14
Genome accession: NC_008463
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1299242 - 1300819 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCCCAAGACATTCACGCCCACCGTATCCTGATCCTCGATTTCGGCTCCCAGTACACCCAACTGATCGCCCGCCGCGT
GCGCGAGATCGGCGTGTATTGCGAAATCCATCCCTTCGACATGAGCAACGAGGCGATCATCGCCTTCGCGCCGCGCGGCA
TCATCCTCGCCGGCGGTCCCGAGTCGGTGCACGAAGCCGACAGCCCGCGCGCGCCGCAGGCGGTGTTCGACCTGAAGGTG
CCGCTGTTCGGCATCTGCTACGGCATGCAGACCATGGCCGAGCAGATGGGCGGCAAGGTGCAGGGCTCCGACGTGCGCGA
GTTCGGCTACGCCCGCGTCGACGTGGTTGGCAAGGCGCGCCTGCTGGACGGCATCGAGGACCACGTGGACGACGACGGCG
TGCTCGGCCTCGACGTGTGGATGAGCCACGGCGACAAGGTCACCGAGATGCCGGCCGGCTTCCACATCCTGGCCAGCACC
CCGAGCTGCCCGATCGCCGCCATGGCCGACGATGCCCGCGCCTACTACGGCGTGCAATTCCACCCGGAAGTCACCCACAC
CAAGCAGGGCCTGCGCATTCTCTCGCGCTTCGTCCTCGACATCTGTGGTTGCGCCGCGCTGTGGACCCCCTCGAACATCG
TCGACGACGCCATCGCCACCGTGCGCGCCCAGGTCGGTTCCTCCAAGGTCCTGCTCGGCCTCTCCGGCGGCGTGGACTCC
TCGGTGGTCGCCGCGCTGCTGCACAAGGCCATCGGCGACCAACTGACCTGCGTGTTCGTCGACAACGGCCTGCTGCGCCT
GCACGAAGGCGACCAGGTGATGGCCATGTTCGCCGAGAACATGGGCGTGAAGGTGATCCGCGCCAACGCCGAGGACAAGT
TCCTCGGCCGCCTGGCCGGCGTCGCCGATCCGGAAGAGAAGCGCAAGATCATCGGCCGCACCTTCATCGAAGTCTTCGAC
GAAGAAGCCACCAAGCTGCAGGACGTGAAGTTCCTCGCCCAGGGCACCATCTACCCCGACGTGATCGAGTCGGCCGGCGC
CAAAACCGGCAAGGCCCACGTGATCAAGTCGCACCACAACGTCGGCGGCCTGCCGGAGGACATGCAGTTCGAACTGGTCG
AGCCGCTGCGCGAACTGTTCAAGGACGAAGTGCGCAAGATCGGCCTGGAGCTGGGCCTGCCCTACGACATGGTCTACCGC
CACCCGTTCCCCGGCCCGGGCCTGGGCGTGCGCATCCTCGGCGAGGTGAAGAAGGAGTACGCCGACCTGCTGCGCCAGGC
CGACCACATCTTCATCGAGGAACTGCGCGCCTTCGACTGGTACCACAAGACCAGCCAGGCGTTCGTGGTGTTCCAGCCGG
TGAAATCGGTCGGCGTGGTCGGCGACGGCCGTCGCTACGCCTGGGTCGTCGCCCTGCGCGCGGTGGAGACCATCGACTTC
ATGACCGCGCGCTGGGCGCACCTGCCCTATGAACTGCTGGAGAAGGTCTCGAACCGCATCATCAACGAGATCGCCGGTAT
CTCCCGGGTCACCTACGACGTGTCGAGCAAGCCGCCGGCGACTATCGAGTGGGAGTGA

Protein sequence :
MSQDIHAHRILILDFGSQYTQLIARRVREIGVYCEIHPFDMSNEAIIAFAPRGIILAGGPESVHEADSPRAPQAVFDLKV
PLFGICYGMQTMAEQMGGKVQGSDVREFGYARVDVVGKARLLDGIEDHVDDDGVLGLDVWMSHGDKVTEMPAGFHILAST
PSCPIAAMADDARAYYGVQFHPEVTHTKQGLRILSRFVLDICGCAALWTPSNIVDDAIATVRAQVGSSKVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMAMFAENMGVKVIRANAEDKFLGRLAGVADPEEKRKIIGRTFIEVFD
EEATKLQDVKFLAQGTIYPDVIESAGAKTGKAHVIKSHHNVGGLPEDMQFELVEPLRELFKDEVRKIGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRQADHIFIEELRAFDWYHKTSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLEKVSNRIINEIAGISRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-122 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-122 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-122 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-108 49