|
Name : ureC (Bamb_0779) Accession : YP_772672.1 Strain : Genome accession: NC_008390 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 867551 - 869257 bp Length : 1707 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGACATTACGCTTGAGCCGCCGCGCGTACGCGGAAATGTTCGGGCCGACGACGGGCGACCGCGTGCGGCTCGCCGATAC CGAACTCTTGATCGAGATCGAACGCGACTACACGATCTACGGCGAGGAAGTGAAATTCGGCGGCGGGAAGGTGATCCGCG ACGGGATGGGCCAGTCGCAGCGCGTGGCCGCCGACGTGCCCGACACGATCATCACGAACGCGGTGATCCTCGATCACTGG GGCATCGTGAAGGCCGACATCGCGATCAAGCACGGCCGCATCGCCGCGATCGGCAAGGCCGGCAACCCGGACATCCAGCC CGGCGTGACGATCGCGATCGGCGCCGCGACCGAAGTGATCGCCGGCGAAGGGCTGATCGTCACCGCGGGCGGCATCGACA CGCACATCCATTTCATCAGCCCGCAGCAGATCGACGAGGCGCTCGCGTCGGGCGTCACGACGATGCTCGGCGGCGGCACG GGGCCGGCCACCGGCACCAACGCGACGACCTGCACGCCGGGCCCGTGGCACATGGAGCGGATGCTGCAGGCGGCCGACGG CTGGCCGATCAACCTCGGCTTCCTCGGCAAGGGCAACGCGAGCCTGCCGCAGCCGCTCGTCGAGCAGATCGCGGCCGGTG CGATCGGCCTGAAGCTGCATGAAGACTGGGGCACGACGCCTGCCGCGATCGACAACTGCCTGTCGGTGGCCGACGACACC GACACGCAGGTCGCGATCCACACCGACACGCTGAACGAAGCCGGCTTCGTCGAATCGACGGTCGCCGCGTTCAAGGGCCG CACGATCCACACGTACCACACCGAAGGCGCGGGCGGCGGCCATGCGCCCGACATCCTGAAGGTGTGCGGCGAGGCGAACG TGCTGCCGTCGTCGACCAACCCGACGCGCCCGTACACGATCAACACGCTCGACGAGCATCTCGACATGCTGATGGTGTGC CATCACCTCGATCCGTCGATCGCCGAGGATCTCGCGTTCGCCGAATCGCGGATCCGCCGCGAGACGATCGCGGCCGAGGA CATCCTGCACGATCTCGGCGCCCTGTCGATGCTGTCGTCCGACTCGCAGGCGATGGGCCGCGTCGGCGAAGTGATCATCC GCACCTGGCAGACCGCGCACAAGATGAAGGTGCAGCGCGGCGCGCTGCCGGAAGACGGCGCCCGCAACGACAACTTCCGC GCGAAACGCTACGTCGCGAAGTACACGATCAACCCGGCGATCACGCACGGGATCGCGCACGAAGTCGGGTCGATCGAACC CGGCAAGTGGGCCGACCTCGTCCTGTGGGAACCGGCGTTCTTCGGGATCAAGCCGTCGATGATCCTGAAGGGCGGGATGA TCGCGGTCGCGCAGATGGGCGACCCGAACGCGTCGATCCCGACACCGCAGCCGGTCCACTACCGCGAGATGTTCGCGACA CGCGGCGGCGCGCTCGCGCGCACGTCGCTCACCTTCGTGTCGCAGATGGCCGCCGACGCGGGCATCGCCGAACGCTACGG GCTCGCGAAGCGCATCGTGCCGGTGCGCAACTGCCGCAACGTGACGAAGGCCGACATGATCCACAACGCATGGCGCCCGT CGATCAGCGTCGACCCCGAAACCTACGACGTGATCGCCGACGGCCAGTTGCTCACCTGCGAGCCGGCGTCGGTGCTGCCG ATGGCGCAACGCTATTTCCTGTTCTGA Protein sequence : MTLRLSRRAYAEMFGPTTGDRVRLADTELLIEIERDYTIYGEEVKFGGGKVIRDGMGQSQRVAADVPDTIITNAVILDHW GIVKADIAIKHGRIAAIGKAGNPDIQPGVTIAIGAATEVIAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMLGGGT GPATGTNATTCTPGPWHMERMLQAADGWPINLGFLGKGNASLPQPLVEQIAAGAIGLKLHEDWGTTPAAIDNCLSVADDT DTQVAIHTDTLNEAGFVESTVAAFKGRTIHTYHTEGAGGGHAPDILKVCGEANVLPSSTNPTRPYTINTLDEHLDMLMVC HHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALPEDGARNDNFR AKRYVAKYTINPAITHGIAHEVGSIEPGKWADLVLWEPAFFGIKPSMILKGGMIAVAQMGDPNASIPTPQPVHYREMFAT RGGALARTSLTFVSQMAADAGIAERYGLAKRIVPVRNCRNVTKADMIHNAWRPSISVDPETYDVIADGQLLTCEPASVLP MAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 71 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 71 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-170 | 64 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-171 | 63 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-171 | 63 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-171 | 63 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_772672.1 | urease subunit alpha | VFG0270 | Protein | 9e-161 | 66 |
