Gene Information

Name : thyA (FTH_0717)
Accession : YP_763301.1
Strain : Francisella tularensis OSU18
Genome accession: NC_008369
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 709069 - 709893 bp
Length : 825 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCGAGAATATCTAAATTTCCTTAAGTATATCAAAGAAAATGGCGTTTTAAAGAATGATAGAACCGGTACTGGAACAAG
AAGTATCTTTGGCTATCAAATGCGTTTTGATCTTCAAAAAGGCTTCCCATTAGTAACTACAAAAAAAATTCATATTCCTA
GTGTTGTTCATGAATTATTATGGTTTTTAAGTGGTAGTACAAATATCAAATATCTTAATGATAACAATGTTAGAATTTGG
AATGAGTGGGCAACTGTAGATGGCGAACTTGGTCCTATTTATGGCAAGCAGTGGCGTGATTTTAATGGTCAAGGTATAGA
TCAAATTGCCGATGTAATTCAGATGCTAAAAACAAACCCAAACTCACGTAGGATTCTAGTTTTAGCGTGGAATCCATGTG
TTGTTCCATCAGAAAAAATCTCTCCACAAGAAAATGTTGTAAAAGGTAATTCAGCCCTACCACCATGCCATGCAATGTTT
CAGTTCTATGTAGCAAATAATAAACTATCATGCATGCTTACGCAAAGAAGTGCTGATGCTTTTCTTGGAGTACCATTTAA
CATTGCAAGTTATTCACTACTGACACATATGGTTGCACAACAATGTAATCTTGATGTTGGTGAGCTCATCTGGTCAGGTG
GTGATTGTCATATTTACAATAATCATATTGAGCAAGTCAATGAACAGCTTAGTCGTGAGCCTTTAGCTTTACCAACACTA
AAGATTTTAAGAAAATCAAACTCCATCTTTGATTATAAATACGAAGATTTTGAATTTGAAAACTATAACCATCACCCTGC
CATCAAAGCAAAAATATCTGTATAA

Protein sequence :
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIW
NEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMF
QFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
KILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 3e-73 58
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 5e-48 45