Gene Information

Name : merA (HNE_1691)
Accession : YP_760397.1
Strain : Hyphomonas neptunium ATCC 15444
Genome accession: NC_008358
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 1731485 - 1732909 bp
Length : 1425 bp
Strand : +
Note : identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein fa

DNA sequence : 
ATGAAACACGAATGCTGCGCGCCGAACTGTGAGTACGACCTCGCCGTGATTGGTGCCGGATCGGCTGGATTCTCCGCCGC
TATTACGGCCGCAGAGGGCGGTGTGCGCGTGGCTCTTATAGGGCACGGTACGATTGGCGGTACCTGCGTGAACGTCGGAT
GCGTCCCCTCCAAGACGATGATCCGCGCCGCTGAGGCGGTGTTTAGTGCGCAGTCGGCGCATCGGTTCCCGGGACTCAGG
GGAGAAGCGCAGGTTTCTGACTGGGCGGCGCTGATCGCAGCAAAGGAAGATCTCGTCGCGTCACTGCGGCAGAAAAAATA
CGCCAACTTGCTACCAGGCTATCATGGTGTGACTTACATCGATGAGGGGCCAGCGCGGCTCGTACTTGGCGGTGTGGAGG
TCGGCGGACGGAAGATCAAGGTATCCAAGGTCATCGTCGCCACTGGCGGCCGCTCGGCCGTTCCTGACGTCGCCGGTATT
TCGGAGGTGCCGACGCTCGACAGCACGGCGCTCCTGGAGCTGAAGGCGCTGCCCGAGAGCCTGATCTTCCTCGGCGGCGG
CTATATCGGTGTGGAACTCGCACAGATGATGGCGAGGCTGGGTACCCGCGTCACGATCGTGTGCCGCTCGCGGTTGTTGC
CGCGCGCTGAACCAGAGGTGTCCGAGGCGCTCGCGAAGGCACTGCGCGCCGAGGGCATCTCGGTTGTGGAAAAGGTAACC
TATGACGCCGCACGGCTGGACGGCAGCCGCACAGTCGTGACGGTAACGGTGAACGGTGCCGCCAGAGACCTGGCGGCTGA
TCACCTTGTCCTGTCGACTGGGCGCATTCCCAACACGGATGGGCTGGGGCTCAAAGAGATGGGTGTCGAGACTGATCAGC
GGGGCGCGATCATCGTTGGCGATGATATGGCCACCACACGTTCCGGTGTATACGCAGCAGGCGACGTAACTGACCGGGAT
CAGTTCGTATACATGGCCGCTTATGGCGCCAAGCTGGCGGCGCGAAATGCGGTACTGGGAGGGAAGGAATGCTACGACAA
CGCCGCGATGCCGTGGGTGGTTTTCTGCGATCCGCAGATTGCAGGTGTCGGTCTGACCGAGGCGCAGGCTTACGCCGCAG
GCTATGATGTCAAGACCAGTGTGCTTCCGCTTGAGAATGTTCCTCGGGCGCTCGCGGCACGCAATACCACAGGGCTGATC
AAGTTGGTCGCAGACCGGGCTAATGACCGACTGCTCGGCGGTGTGATCATGGCGCAGGAAGGCGCTGATAGTATCCAGAC
ACTTTCACTGGCACTGAAGTTCGGCATGACGACAAAGGCGCTCGGCGAAACCATTTTCCCTTATTTAACGACAGTCGAGG
GGTTCAAGCTGGCGGCGCAGACTTTCGACAAGGATGTCGCGAAACTCTCCTGTTGCGCGGGCTGA

Protein sequence : 
MKHECCAPNCEYDLAVIGAGSAGFSAAITAAEGGVRVALIGHGTIGGTCVNVGCVPSKTMIRAAEAVFSAQSAHRFPGLR
GEAQVSDWAALIAAKEDLVASLRQKKYANLLPGYHGVTYIDEGPARLVLGGVEVGGRKIKVSKVIVATGGRSAVPDVAGI
SEVPTLDSTALLELKALPESLIFLGGGYIGVELAQMMARLGTRVTIVCRSRLLPRAEPEVSEALAKALRAEGISVVEKVT
YDAARLDGSRTVVTVTVNGAARDLAADHLVLSTGRIPNTDGLGLKEMGVETDQRGAIIVGDDMATTRSGVYAAGDVTDRD
QFVYMAAYGAKLAARNAVLGGKECYDNAAMPWVVFCDPQIAGVGLTEAQAYAAGYDVKTSVLPLENVPRALAARNTTGLI
KLVADRANDRLLGGVIMAQEGADSIQTLSLALKFGMTTKALGETIFPYLTTVEGFKLAAQTFDKDVAKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 6e-87 45
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 5e-87 45
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 8e-70 44
merA AFG30120.1 MerA Not tested PAGI-2 Protein 8e-70 44
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 1e-69 44
merA AGK07079.1 MerA Not tested SGI1 Protein 3e-74 44
merA ABQ57371.1 MerA Not tested SGI1 Protein 3e-74 44
merA AGK07021.1 MerA Not tested SGI1 Protein 3e-74 44
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 6e-71 44
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 4e-74 44
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 9e-71 44
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 2e-72 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_760397.1 mercuric reductase BAC0651 Protein 3e-87 45
merA YP_760397.1 mercuric reductase BAC0652 Protein 6e-73 44
merA YP_760397.1 mercuric reductase BAC0653 Protein 2e-74 43
merA YP_760397.1 mercuric reductase BAC0650 Protein 8e-66 41