Gene Information

Name : guaA (Swol_1784)
Accession : YP_754453.1
Strain : Syntrophomonas wolfei Goettingen
Genome accession: NC_008346
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2036822 - 2038354 bp
Length : 1533 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAATAAAGAAACGGTTGTGGTACTGGATTTTGGAGGACAATATAACCAACTGATTGCCCGCCGGGTGCGAGAGTTATC
GGTGTATAGCGAGATGCTTCCTTATGATACTAGCTATGAAGAAATAGTGGCTAAGAAACCTCAGGCTATAATATTGACCG
GAAGTCCGGCCAGCGTTCATGGGGGTGAGGCTCCGGGTTGCGACCCCCGGGTTTTTTCCCTGGGTATTCCCGTTCTGGGT
ATTTGTTACGGTATGCAGTTAATGGCCGAGCAAATGGGCGGGAAGGTTCAACCCTCTTCTTTGCGCGAATATGGGCGTGC
AGTTTTACAGCTAACGGGGAAGGATGAAATATTTAAAGGTCTTCCTGATGAAATGCAAGTATGGATGAGCCATGGGGATA
CTATTATTAGCCTGCCCGAGGGTTTCAGAATAACGGCAAGTACGGCTAATTGTCCAGTAGCAGCGATCAGTTGCCCACAG
CGCCGGCTTTACGGGGTGCAGTTTCATCCCGAGGTAAGACATAGTACCTATGGTATGGATATAATAAGAAATTTCTTGTT
TGAGATTTGTGGTCTTCGCGGAGATTGGGATCTTAGTGATTTTATTAGTGAAGCCATTGAGGAGATCAAAAACAAAGTAG
GAAAGAAGCGAGTTCTTTGTGCCTTAAGTGGAGGTGTGGATTCTTCCGTGGCGGCCACCCTGGTACACCAGGCCGTGGGG
GAGCAATTAGTATGTGTTTTTGTGGATAATGGTCTTTTAAGAAAAGGAGAAGCTAGCCAGGTAATTGATACTTTTGCCAA
AGAAATGAAGATGAACCTGGTTTTTGTAGATGCAAGGGAAAGATTTCTGGCCAAACTGGCTGGAATTACTGAACCGGAGA
GGAAACGCAAGATTATCGGGGAAGAGTTTATCCGCATCTTTGAGGAAGAGAAAGCTAAACTGGGAGAAATAGACTACCTG
GTTCAGGGAACTATTTATCCGGACATTGTGGAGAGCGGTACCAGCACCGCACAGACCATAAAAAGCCACCATAATGTGGG
AGGATTGCCGGAGGACATGGATTTCCAACTCATTGAACCTCTGCGCTTGCTCTTTAAAGATGAAGTCCGCCTGGTAGGAG
AAAAGCTGGGCATCCCTGCGGAGATTCTATGGCGTCAGCCATTTCCCGGGCCTGGTCTGGGGGTAAGGGTGCTGGAAGAA
GTTAGCTTTGAAAAACTGGAGATATTGCGGGAAGCCGATGCGATTGTCCGCGACGAAATAAAAAAGGCCGGTCTGGAAAG
GGAAATCTGGCAGGCTTTTGCCGTTCTGCCCCCGGTAAGGAGTGTGGGTGTAATGGGGGATGCTCGTACCTATGCCTATC
CCATAATTATTCGAGCCGTAATCAGCGAAGATGCCATGACGGCGGAAGTGGCGCGACTTCCCTGGGAACTCCTGGATATA
ATGGCGCGCCGTATTGTCAATGAAGTAGCCGGTGTCAACCGGGTGGCCTATGACATCACTTCCAAGCCTCCCGGAACCAT
TGAGTGGGAATAA

Protein sequence :
MNKETVVVLDFGGQYNQLIARRVRELSVYSEMLPYDTSYEEIVAKKPQAIILTGSPASVHGGEAPGCDPRVFSLGIPVLG
ICYGMQLMAEQMGGKVQPSSLREYGRAVLQLTGKDEIFKGLPDEMQVWMSHGDTIISLPEGFRITASTANCPVAAISCPQ
RRLYGVQFHPEVRHSTYGMDIIRNFLFEICGLRGDWDLSDFISEAIEEIKNKVGKKRVLCALSGGVDSSVAATLVHQAVG
EQLVCVFVDNGLLRKGEASQVIDTFAKEMKMNLVFVDARERFLAKLAGITEPERKRKIIGEEFIRIFEEEKAKLGEIDYL
VQGTIYPDIVESGTSTAQTIKSHHNVGGLPEDMDFQLIEPLRLLFKDEVRLVGEKLGIPAEILWRQPFPGPGLGVRVLEE
VSFEKLEILREADAIVRDEIKKAGLEREIWQAFAVLPPVRSVGVMGDARTYAYPIIIRAVISEDAMTAEVARLPWELLDI
MARRIVNEVAGVNRVAYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-149 58
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-148 58
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-148 58
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-130 54