Gene Information

Name : Neut_0084 (Neut_0084)
Accession : YP_746337.1
Strain : Nitrosomonas eutropha C91
Genome accession: NC_008344
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 81615 - 83741 bp
Length : 2127 bp
Strand : -
Note : TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2

DNA sequence :
ATGTCCAGCGCCAAAGCCCTAAAGCTACGCATCGAGGGGATGGATTGCGGCGCCTGTGCAGTCAAGATAGAAAACGCCAT
GAAGCGGTTGCCTGGCGTTACCGATATCAATGTCAGCTATGGCCGGGAAAGTTTGGCCTTGTCATTTGATGAAGACCGCA
GTAGCCAGCACAATATCGAAGCACAAATCCGTGCGCTTGGGTTTACACCGGTTCGCGAGGGGGCTGTTGGCACTCGAGCG
TCAGCCGCTGAACGGGAGTCGCTGCCTTTCTGGGCCGGGAAAAAAGCCAAGTTAGTGTGGATGACGGGGCTGGCGTTCGC
CGTAGCCGTTGGCATAGCGCAATTTTTCCCGCAGTGGGAGCGTTGGGCGTACTCCGCAGCCGCATTTGTTGGCATCATTC
CGGTCGTTCGACGGGCCTACGCCAGTGCCATCACGGGAACCCCGTTCAGTATCGAAACGCTCATGTCCGTGGCGGCCCTC
GGGGCACTCGCGATCGACGCCGCCGAAGAGGCGGCCGTAGTGATATTTCTATTTGCGGTGGGCGAACTGCTCGAAACGGT
GGCAGCCGGGCGGGCACGTTCCGCGATCAAGGCACTCATGGATCTGGCGCCAAGACAGGCCATCCGCGAGCAAGACGGAA
AACTTGAAACTGTGCCCGTAGAGCAGTTGGCGATTGGAGATATCGCGATCGTCAGGCCAGGCGATCGTGTGCCATCCGAC
GGCAGCGTGCTTGAAGGCATATCCGAGGTGAACGAGGCGCCTATTACCGGTGAGTCGGTGCCTGTGGCAAAGGAGCCCGG
GGCGAATCTCTACGCCGGTAGCATCAACGGCAATGCGGAGCTGCGCATGTCGATCTCGCGCGCGGCAAGCGACAACACTA
TTGCGCGAATCATTCATATGGTCGAAGAGGCCCAGGAGTCCAAGGCCCCACTGGCGCGCTTCATTGACCGGTTCAGCAGC
ATTTACACGCCAGTAGCGATGGTGGTGTCCTTGCTTATTGTCATCGTGCCGCCGTTGTTGTTTGGTGGCGACTGGATGAC
ATGGATCTATCGCGGCCTGGCTACTTTGCTGATTGCCTGTCCGTGCGCGTTGGTCATTTCCACTCCTGCGGCAATCGCCT
CCGGCTTGGCTGTTGGGGCGCGGCGTGGGTTGTTGGTCAAGGGTGGAGCAGCCCTTGAAACACTGGGCAAGCTCAAAACG
GTCGCGTTCGACAAGACTGGAACACTCACCGAAGGACGTCCACGCATCACCGACATCGTGACCCTTAACGGTACCGAGGA
CGAGGTGCTGGCTCGAGCCGCAGCGGTCGAGCGCAAGACCAGCCATCCCTTGGGAGCCGCTATCGTGGAGGCGGCTGAGG
CACGAAATCTGGAACTGCCTCAGAGTTTTGGCGCGGCGTTGGCCATTCCTGGCAAGGCGGTTACGGCTCGTCTAAAGTCT
GGGTTCGCCTCCGTTGGATCGCCGCGCTATGCCGAGGAGCTTGCTCCCATCGAGGAGTCAGTTCGGCAAACCATTTCCGC
GCTCGAGCAAGCGGGTAAGACAGTGGTCGTGGTATTGGCCGGAAAACGGATTGATGGCTTAATCGCGCTTCGCGATGAGC
CGCGCCAGGATGCTGCGCAGGCACTAAAGCGCTTGGCGGATATGGGTATCAAAACCGTCATGCTGACGGGTGACAATCGC
CGCACCGGTGATGCCATTGGGCGGGCGCTTGGGGTCGGCGTGCAGGCCGAACTACTGCCCGAAGCGAAGCTGGCTGCTAT
TGACGGGCTCAAGCAGGATGGGCATGTGGCGATGGTGGGAGACGGGATCAACGACGCCCCCGCACTGGCTACGGCTTCAG
TTGGCGTAGCCATGGGAGGCGGAACGGACGTTGCGCTCGAAACGGCCGATGCCGCACTGCTTCAGAACCGGGTCATGGGC
ATCGCGGATCTGATCGACTTGTCGCGCGCCACATTGGGCAATATCTGGCAGAACATCGGACTAGCATTGGGCCTGAAGGC
AATTTTTCTGGTGACCACGATACTGGGCGTTACCACGCTTTGGATGGCTATCCTGGCGGATACGGGCGCTACCGTTCTCG
TCACGGCGAACGCACTACGTTTGCTGCGCTACAGAAGCCAGGACTGA

Protein sequence :
MSSAKALKLRIEGMDCGACAVKIENAMKRLPGVTDINVSYGRESLALSFDEDRSSQHNIEAQIRALGFTPVREGAVGTRA
SAAERESLPFWAGKKAKLVWMTGLAFAVAVGIAQFFPQWERWAYSAAAFVGIIPVVRRAYASAITGTPFSIETLMSVAAL
GALAIDAAEEAAVVIFLFAVGELLETVAAGRARSAIKALMDLAPRQAIREQDGKLETVPVEQLAIGDIAIVRPGDRVPSD
GSVLEGISEVNEAPITGESVPVAKEPGANLYAGSINGNAELRMSISRAASDNTIARIIHMVEEAQESKAPLARFIDRFSS
IYTPVAMVVSLLIVIVPPLLFGGDWMTWIYRGLATLLIACPCALVISTPAAIASGLAVGARRGLLVKGGAALETLGKLKT
VAFDKTGTLTEGRPRITDIVTLNGTEDEVLARAAAVERKTSHPLGAAIVEAAEARNLELPQSFGAALAIPGKAVTARLKS
GFASVGSPRYAEELAPIEESVRQTISALEQAGKTVVVVLAGKRIDGLIALRDEPRQDAAQALKRLADMGIKTVMLTGDNR
RTGDAIGRALGVGVQAELLPEAKLAAIDGLKQDGHVAMVGDGINDAPALATASVGVAMGGGTDVALETADAALLQNRVMG
IADLIDLSRATLGNIWQNIGLALGLKAIFLVTTILGVTTLWMAILADTGATVLVTANALRLLRYRSQD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 8e-112 41
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 7e-112 41
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 1e-107 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Neut_0084 YP_746337.1 heavy metal translocating P-type ATPase BAC0461 Protein 8e-126 47
Neut_0084 YP_746337.1 heavy metal translocating P-type ATPase BAC0092 Protein 4e-81 44
Neut_0084 YP_746337.1 heavy metal translocating P-type ATPase BAC0298 Protein 1e-100 41