Gene Information

Name : guaA (Neut_2251)
Accession : YP_748433.1
Strain : Nitrosomonas eutropha C91
Genome accession: NC_008344
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2376237 - 2377796 bp
Length : 1560 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCATTCAGCAATTCTTATCCTGGATTTTGGCTCGCAGTACGCTCGTTTAATCGCACGGCGCATCCGGGAAACCAGTGT
TTACTGTGAACTCCACCCCTTTGATGTCAGCCCGCAATTTATTCGGGAATTTTCTCCTGTTGGCATCATTCTCTCCGGCG
GGCCGGCATCCATCTTTACCAATGACGCGCCGCGTGTGCCTCAAATTGTGTTTGAACTGGGTGTCCCTGTTCTCGGCATA
TGTTATGGAATGCAGGCCATGGCAGCTCAGCTCGGAGGAGAGGTGGAAAATGCGCAAACGCGCGAATTTGGCTATGCAGA
ATTGTTAACAGAACCATGCAGGCTGTTCCAGGACATCAAGGATCGCATCAACTCTGATGGCAAACCCGCTCTTGATGTAT
GGATGAGCCACGGTGACCGGGTTAATAAATTACCGCCTGGGTTCACAGCCATTGCCTTCAATGCAGCCACTCCCTTTGCA
GCCATGGCTGACGAAACACGCAGGTTCTACGGTGTCCAGTTCCATCCTGAAGTCACTCACACCCTTCAGGGAAAAGCTAT
CCTCGATCGTTTCGTTCATGATATCTGTGATGCGGGCTATGACTGGAACATGCCGGATTACGTAGAAGAGGCCATTGGCC
GGATACGCGCGCGCGTCGGCGGCGATAAAGTCATCCTGGGATTGTCTGGGGGGGTAGATTCTTCAGTAGCCGCCGCACTA
ATCCACCGCGCCATCGGTGATCAGCTGGTATGCGTATTCGTAGACAACGGCCTGCTCCGCCTGAATGAAGCCAAGCAAAC
CATGGAAACCTTTAGCCGGAATCTTGCGGTCAACGTCATCTACGTTGATGCTAGCAGACAATTCCTGGAGCAATTGAAAG
GAATCACTGATCCGGAACAGAAACGCCGCACCATCGGCCGCGAATTTGTGGAAATCTTTCAGCAGGAAGCCGCAAAAATT
GAAAACGTCAAATGGCTGGCGCAAGGCACCATTTATCCGGATGTCATTGAATCTGCCGGCAGCCACACAAAGAAATCAGG
ATTAATCAAATCCCACCATAACGTTGGTGGTCTACCAGAAACACTTCGCCTCAAATTGCTGGAACCACTGCGTGAACTGT
TCAAGGATGAAGTACGAGAACTTGGCTTGGCACTGGGACTGCCGCGTGACCTAGTATTTCGTCATCCCTTTCCCGGGCCG
GGACTGGGTGTCCGTATTCTTGGAGAAGTTAAATATGAATACACAGAATTATTGCGCCAGGCTGATGCCATCTTTATTGA
AGAGCTGAGAAACGCTGGATGGTATGAAAAAACCTCCCAGGCATTTGCTGTTTTCCTGCCAATAAAATCAGTTGGCGTTA
TGGGAGATAACCGCAGTTATGAGTATGTCATCGCGCTGCGCGCCGTTCAGACTGAAGATTTCATGACGGCACAATGGGCT
GAACTGCCTTACACCCTGCTGGCCAGAATCTCCAACCGCATCATCAACGAAATTCGTGGCATCAACCGTGTGGTTTACGA
TATCTCAGGCAAACCCCCCGCGACCATCGAGTGGGAATGA

Protein sequence :
MHSAILILDFGSQYARLIARRIRETSVYCELHPFDVSPQFIREFSPVGIILSGGPASIFTNDAPRVPQIVFELGVPVLGI
CYGMQAMAAQLGGEVENAQTREFGYAELLTEPCRLFQDIKDRINSDGKPALDVWMSHGDRVNKLPPGFTAIAFNAATPFA
AMADETRRFYGVQFHPEVTHTLQGKAILDRFVHDICDAGYDWNMPDYVEEAIGRIRARVGGDKVILGLSGGVDSSVAAAL
IHRAIGDQLVCVFVDNGLLRLNEAKQTMETFSRNLAVNVIYVDASRQFLEQLKGITDPEQKRRTIGREFVEIFQQEAAKI
ENVKWLAQGTIYPDVIESAGSHTKKSGLIKSHHNVGGLPETLRLKLLEPLRELFKDEVRELGLALGLPRDLVFRHPFPGP
GLGVRILGEVKYEYTELLRQADAIFIEELRNAGWYEKTSQAFAVFLPIKSVGVMGDNRSYEYVIALRAVQTEDFMTAQWA
ELPYTLLARISNRIINEIRGINRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-109 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-109 50
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-109 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-99 48