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Name : ureC (GbCGDNIH1_2164) Accession : YP_745985.1 Strain : Granulibacter bethesdensis CGDNIH1 Genome accession: NC_008343 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 2411596 - 2413305 bp Length : 1710 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGCCCGCCTTTCCCGCGCCGCCTATGCCGGCATGTATGGTCCTACCACCGGGGACCGCCTGCGTCTGGCTGATACCGA TCTGATCATCGAGGTGGAGCGCGACCTGACCACCTATGGCGAGGAGGTCAAATTCGGCGGTGGCAAGGTTATCCGTGACG GCATGGGCCAGTCGCAGATGATCAACGCTGCCGGTGCGATGGATACGGTCATTACCAATGCCCTGATCGTCGATCATTGG GGCATCGTGAAGGCGGATGTCGGGCTGAAAGCGGGTCGTATCGCCGCGATCGGCAAAGCCGGCAATCCCGACACCCAGCC CGGTGTGGATATCGTGATCGGCCCCGGCACGGAGATCATCGCCGGAGAGGGGCGCATCCTCACCGCGGGCGGGATCGACG TGCACATCCATTTCATCTGCCCGCAGCAGATCGAGGAAGCGCTGTCCGCAGGCATGACCACCCTGTTCGGCGGCGGCACC GGTCCAGCACACGGCACACTGGCCACCACCGTAACACCCGGCCCCTTTCATCTGCACCGGATGCTGAAAGCGGCCGAAGG ATTTCCGATCAATCTCGGTTTTCTCGGCAAAGGCAATGCCACCCTCCCCGCCGCCCTGGAAGAGCAGATCTTGGCGGGGG CCGCAGGGCTGAAACTGCATGAAGATTGGGGCTCCACCCCTGCCGCAATTGACAACTGCCTGTCTGTCGCCGATGCGCTG GATGTTCAGGTTGCCTTGCACTCGGATACGCTGAACGAGGCGGGCTTCGTGGAAAGCACCATCGCCGCGCTACGTGGACG CACCATTCAGGCTTTCCACACCGAAGGCGCAGGCGGGGGTCACGCGCCGGATATTCTGCAACTGGTGGGGGAAGCCAACG TGCTGCCCAGCTCCACCAACCCCACCATGCCCTATACAGTGAACACGGCTGACGAGCATCTGGATATGCTGATGGTCTGC CACCACCTTGATGCCCGCATTCCCGAGGACGTCGCCTTCGCAGAAAGCCGCATCCGGCGTGAAACCATCGCCGCCGAGGA TATTCTGCACGATCTGGGTGCCATTTCGATCCTCAGCTCCGACAGTCAGGCGATGGGACGGGTAGGAGAAGTCATCATCC GCACCTGGCAGACCGCGCATAAGATGAAGCAGCAACGCGGCCGCCTGCCCGGTGAGACGGGCGATAACGACAATCTGCGG GTGCGGCGCTACATCGCGAAATACACCATCAATCCCGCGCTTGCGCAGGGGATCGCCGATCATGTCGGCAGCGTGGCAGT TGGCCTGTTTGCCGATCTTGTGCTGTGGTCGCCAGCGTTTTTCGGCGTCAAACCCGATATGGTGCTGAAGAACGGTACCA TCGTGATGGCCCCGATGGGCGATCCCAATGCCTCGATCCCCACCCCACAACCGGTACATTACCGGCCTATGTTCGGCGCT TACGGAGCAGCGCTGCCGGAATGCGGCCTGATTTTTGTCTCCGGGGCTTCTCTGACACACGGTCTGGCGGAGAAGCTGCA AAGCCGTCGCGCCCTGCTGCCGGTGAAGAACACCCGGTCCGGCCTGTCGAAACGGGATATGGTGCTGAATGATTACTGTC CGCATATCGAAGTCGACCCGGAAACCTATGAAGTCAGGGCCGATGGTGAATTGCTGATCTGTGAGCCGGCGGAGATATTA CCGATGGCGCAACGGTATTTTCTGTTCTGA Protein sequence : MARLSRAAYAGMYGPTTGDRLRLADTDLIIEVERDLTTYGEEVKFGGGKVIRDGMGQSQMINAAGAMDTVITNALIVDHW GIVKADVGLKAGRIAAIGKAGNPDTQPGVDIVIGPGTEIIAGEGRILTAGGIDVHIHFICPQQIEEALSAGMTTLFGGGT GPAHGTLATTVTPGPFHLHRMLKAAEGFPINLGFLGKGNATLPAALEEQILAGAAGLKLHEDWGSTPAAIDNCLSVADAL DVQVALHSDTLNEAGFVESTIAALRGRTIQAFHTEGAGGGHAPDILQLVGEANVLPSSTNPTMPYTVNTADEHLDMLMVC HHLDARIPEDVAFAESRIRRETIAAEDILHDLGAISILSSDSQAMGRVGEVIIRTWQTAHKMKQQRGRLPGETGDNDNLR VRRYIAKYTINPALAQGIADHVGSVAVGLFADLVLWSPAFFGVKPDMVLKNGTIVMAPMGDPNASIPTPQPVHYRPMFGA YGAALPECGLIFVSGASLTHGLAEKLQSRRALLPVKNTRSGLSKRDMVLNDYCPHIEVDPETYEVRADGELLICEPAEIL PMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 69 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 69 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 5e-160 | 62 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-160 | 62 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 6e-160 | 62 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-160 | 62 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_745985.1 | urease subunit alpha | VFG0270 | Protein | 1e-161 | 62 |
