Gene Information

Name : Mlg_0423 (Mlg_0423)
Accession : YP_741267.1
Strain : Alkalilimnicola ehrlichii MLHE-1
Genome accession: NC_008340
Putative virulence/resistance : Resistance
Product : dihydrofolate reductase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : 1.5.1.3
Position : 473184 - 473684 bp
Length : 501 bp
Strand : -
Note : PFAM: dihydrofolate reductase region; KEGG: bmb:BruAb1_1393 FolA, dihydrofolate reductase

DNA sequence :
ATGAGCCCACGCCCCGAGATCACCCTCATCGCCGCCCTGGCCGATAACGGCGTCATCGGCCGCGACAACGACCTGCCCTG
GCGCATCCCCGCCGACCTGAAGCGCTTCAAGGCCCGCACCCAGGGCCGCCCCCTCATCATGGGCCGGCGCAACTACGAGT
CCATCGGCCGCCCCCTGCCGGGCCGCCACAACATCGTGCTCACCCGTCGCCGGGACTGGCAGGCCGAGGGCTGCACCGTG
GTCCACGACCCCGAGGCCGCGTTGGCGGCCGCGGGCGACGTGGAAGAGGTGATGGTGATTGGCGGCGAGGAGATCTACCG
CCTCTTCCTACCCCGGGCCGACCGCCTGGAACTCACCCGGGTCCACACCGAAGTGCCCGGCGACACCTTCTTCCCCGACA
TCGACCCCGCGGACTGGCAGGTCGTCGCCGAGCAGCAGCCCCCCAGCGAAGAAACCAACGACTGGCCCCTCACCTACCAG
ACCCTGGAGCGCCGCCGCTGA

Protein sequence :
MSPRPEITLIAALADNGVIGRDNDLPWRIPADLKRFKARTQGRPLIMGRRNYESIGRPLPGRHNIVLTRRRDWQAEGCTV
VHDPEAALAAAGDVEEVMVIGGEEIYRLFLPRADRLELTRVHTEVPGDTFFPDIDPADWQVVAEQQPPSEETNDWPLTYQ
TLERRR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dfrA5 AET25387.1 dihydrofolate reductase Not tested PAGI-2(C) Protein 4e-10 41
dfrA5 AFG30110.1 dihydrofolate reductase Not tested PAGI-2 Protein 4e-10 41
dfrA1 ADZ05803.1 trimethoprim-insensitive dihydrofolate reductase Not tested AbaR3 Protein 3e-11 41
unnamed AEL12695.1 DfrA5 Not tested AbaR21 Protein 3e-11 41
dfrA12 ACF06156.1 dihydrofolate reductase Not tested Tn5036-like Protein 1e-23 41