Gene Information

Name : leuS (Mlg_0400)
Accession : YP_741244.1
Strain : Alkalilimnicola ehrlichii MLHE-1
Genome accession: NC_008340
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 446060 - 448654 bp
Length : 2595 bp
Strand : +
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGGACGCAAGCTATCAACCCGAACAGATCGAGGCCCAGGCCCAGCGTTACTGGGACGAGCAGCAGAGCTTCGCCGCCCG
CGAGGAGCGTGAGGGCGAGAAATTCTACTGCCTCTCGATGTTCCCCTATCCCAGCGGGCGTCTGCACATGGGCCATGTGC
GCAACTACACCATCGGCGACGTGATCAGCCGCTACCAGCGCATGCAGGGGCGCAATGTGCTCCAGCCCATGGGCTGGGAC
GCCTTCGGCCTGCCCGCCGAAAACGCCGCCATGAAACACGGCGTGCCCCCGGCCCGCTGGACCCGCGAGAACATCGAGAC
CATGCGCGGCCAGCTCCAGCGCCTGGGCTTCGCCTACGACTGGGACCGCGAGTTTGCCACCTGCGACCCGGAGTACTACC
GCTGGGAGCAGTGGCTGTTCACCCGCCTCTACAAGAAGGGCCTGGTCTACAAAAAGACCGCCACCGTCAACTGGGACCCT
GTGGACCAGACCGTGCTGGCCAACGAACAGGTGGTGGACGGCCGGGGCTGGCGCTCCGGTGCGGTGGTGGAGCGGCGGGA
CATCCCCCAGTGGTTCCTGCGCATCACCGACTACGCCGACGAGCTGCTGGAGGCGCTGGACGAGCTGCCCGGCTGGCCGG
AGCAGGTGCGCGCCATGCAGCGCAACTGGATCGGCCGCTCCGAGGGCGTGGAGCTGGATTTTGCGGTGGCGGGGCACAGC
GACACCCTGCGGGTTTACACCACCCGCCCGGACACCCTCTACGGCGTCACCTACGTGGGCCTGGCCCCGGAACACCCGCT
GGCCGCGGAAGCGGCCGAGGGCAACCCGGAGATGCAGCGTTTCATCGAGGACTGCCGCAAGGGCGGGGTGGCCGAGGCCG
ATATCGCCACCATGGAAAAGCGCGGCATGGACACCGGCCTGAAGGCGGTGCACCCGCTCACCGGCGAGCAGGTGCCCATC
TGGGTGGCCAACTTCGTGCTGATGGAATACGGCCACGGCGCGGTGATGGCCGTGCCGGCCCACGACCAGCGGGACTGGGA
GTTCGCCAGCAAGTACGGCCTGGATATCCGCCCCGTGGTGCACCCCTCCGCCGAAGAGCGGGCGGACGTGAGCGAGGGCG
CCTTCACCGACGACGGGGTGCTGGCCGACTCCGGCGAGTTCTCCGGGCTGCCCTCCGCCGAGGCCCGCCAGGCCATCGGC
GAGAAGCTGGAGGGCCTGGGCAAGGGGGAGCGTACGGTTAACTACCGGCTGCGCGACTGGGGCATTTCCCGCCAGCGCTA
TTGGGGCGCGCCCATCCCCATGATCCAGTGCCCGGCGTGTGGCGACGTGCCGGTGCCGGACGAGGATCTGCCGGTGGTGC
TGCCCGAGGATGTGGACGTCACCGGGGGCGGCTCGCCGCTCAAGGACCTGCCGGCGTTCTACCAGACCACCTGCCCCCAA
TGCGGGGGCGAGGCGCGGCGTGAGACCGACACCTTCGACACCTTCATGGAATCCTCCTGGTACTACGCCCGTTTCGCCTG
CGCCGACCAAAAGGGGGCCATGCTGGATGAGCGGGCCGATCAATGGCTGCCGGTGGACCAGTACATCGGTGGCATCGAGC
ACGCCATCCTGCACCTGCTCTACGCCCGCTTCTTCCACAAGCTGATGCGCGACGAGGGCCTGCTGCAGAGCGACGAGCCC
TTCCGCAACCTGCTTACCCAGGGCATGGTCATCGCTGAAACCTACTACCGGGAGCGCGGGGATGGCGGCAAGGACTGGTA
CAACCCCGCCGAGGTCACCGTGCAGCGGGACGAGCGCGGGCGGCCGGTCTCCGCGGTGCTCGAGGACGATGGCGAGCCGG
TGGTCATGGGCGCCATCGAGAAGATGTCCAAGTCCAAGAACAACGGCGTCGACCCGCAGGCGCTCATCGACCGCTACGGC
GCCGACACCGTCCGCCTCTACACCATGTTCGCCGCGCCGCCGGACCAGTCCCTGGAGTGGTCCGACTCCGCCGTGGAGGG
GGCCTATCGCTTCCTGCGCCGGTACTACGGGCTGGTGCGCGACCATGTGGCCGCCGGCCCGGTGCCGGCGTTGGACGTGG
CGTCCCTGGACGACGCCGCCCGCGACCTGCGTCGCAAGGTCCACGAGACCATCGCCAAGGCCTCCGACGACGTGGGCCGG
CGCTACACCTTCAATACCGCCATCGCCGCGGTCATGGAGCTGTGCAACGCCCTGGGTAAGGCGGCGGCCAACGAACCGTC
CGGGGCCGCGCGCGCGGTGCTGCAGGAGGGGCTGGAGGCGGCCACGCTGATCCTGGCGCCCATCGCGCCGCACGTGACCC
ACGTCTGCTGGCAGGCCCTGGGCCATGATGAGGCGGTGATCGATGCCCGCTGGCCGGCGGTGGACGAGTCGGCGCTGACC
CGCGACACCATTGAGCTGGTGGTGCAGGTCAACGGCAAACTGCGCAGCCGGCTGCAGCTGCCCGCCGACGCCGACAAGGC
GGCGGCCGAAGCGGCGGCCCTGGCGGACGAAAAGGTGCAGCGCTTCACCGAGGGCAAGACGGTGCGCAAGGTGATTGTGG
TGCCGGGTAAACTGGTGAATATTGTCGCCAACTGA

Protein sequence :
MDASYQPEQIEAQAQRYWDEQQSFAAREEREGEKFYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQRMQGRNVLQPMGWD
AFGLPAENAAMKHGVPPARWTRENIETMRGQLQRLGFAYDWDREFATCDPEYYRWEQWLFTRLYKKGLVYKKTATVNWDP
VDQTVLANEQVVDGRGWRSGAVVERRDIPQWFLRITDYADELLEALDELPGWPEQVRAMQRNWIGRSEGVELDFAVAGHS
DTLRVYTTRPDTLYGVTYVGLAPEHPLAAEAAEGNPEMQRFIEDCRKGGVAEADIATMEKRGMDTGLKAVHPLTGEQVPI
WVANFVLMEYGHGAVMAVPAHDQRDWEFASKYGLDIRPVVHPSAEERADVSEGAFTDDGVLADSGEFSGLPSAEARQAIG
EKLEGLGKGERTVNYRLRDWGISRQRYWGAPIPMIQCPACGDVPVPDEDLPVVLPEDVDVTGGGSPLKDLPAFYQTTCPQ
CGGEARRETDTFDTFMESSWYYARFACADQKGAMLDERADQWLPVDQYIGGIEHAILHLLYARFFHKLMRDEGLLQSDEP
FRNLLTQGMVIAETYYRERGDGGKDWYNPAEVTVQRDERGRPVSAVLEDDGEPVVMGAIEKMSKSKNNGVDPQALIDRYG
ADTVRLYTMFAAPPDQSLEWSDSAVEGAYRFLRRYYGLVRDHVAAGPVPALDVASLDDAARDLRRKVHETIAKASDDVGR
RYTFNTAIAAVMELCNALGKAAANEPSGAARAVLQEGLEAATLILAPIAPHVTHVCWQALGHDEAVIDARWPAVDESALT
RDTIELVVQVNGKLRSRLQLPADADKAAAEAAALADEKVQRFTEGKTVRKVIVVPGKLVNIVAN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 2e-139 41