Gene Information

Name : guaA (Mlg_1016)
Accession : YP_741859.1
Strain : Alkalilimnicola ehrlichii MLHE-1
Genome accession: NC_008340
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1156389 - 1157966 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTCAGGATATTCACGCCCATCGCATCCTCATTCTCGATTTCGGCTCCCAGTACACTCAATTGATCGCCCGCCGTGT
GCGCGAGGCGGGGGTATACTGCGAGATCTACGCCTGGGACGCCCCGGAGACGGCGATCCGCGATTTCGGTGCGGCCGGTT
TTATCCTCTCCGGCGGGCCGGAGTCCATGACGGTGGACAACGGCCCGCGGGTCCCCGAGGCCGTCTTCCAGGCCGGCGTG
CCGGTACTCGGCATCTGCTACGGCATGCAGGCCATGGCGGGCCAGTTGGGCGGCCGGGTGGAAGCCTCCGATCACAAGGA
GTTCGGCTATGCGCGGGTGCGCGCTCGCGGCCACTCGCGCCTGCTGCGCGACATCGAGGACCACGCCAGTCCCGAGGGCT
GGGGGCTGCTGGACGTCTGGATGAGCCACGGTGACCGGGTCACCGGCTTGCCCCCGGGGTTCAAGCTCATTGCCAGCACC
GAGAGCTGCCCCATCGCCGGCATCGGTGACGACGAGCGCGGCTATTACGGGGTGCAGTTCCACCCGGAGGTCACCCATAC
GCCTCAGGGGGCCCGTATCCTCTCCCGTTTCGTCCATGAGATCTGCGGCTGTCCGGCGGACTGGACGCCGGGGAATATCG
TCGATGATCTGATCGAGCGTGTCCGGCGCCAAGTGGGCGGGGACAAGGTGCTCCTGGGGCTCTCCGGGGGGGTGGATTCC
TCCGTGGTGGCGGCGCTGCTGCACCGGGCCATCGGCGACCAGCTGACCTGCGTCTTCGTGGACAACGGCCTGCTGCGCAA
GGACGAGGGCGATCAGGTGATGGCCACGTTCGCCCGGCACATGGGCGTGAACGTCATCCGGGTGGATGCCGAGGCGCGCT
TTCTTGAGGCCCTGAAGGGCGTCGACGACCCGGAGCGCAAGCGCAAGATCATTGGCAATATGTTCATTGAGGTCTTCGAC
GAGCAGGCCGCCCGCCTGACCGAGGTGGACTGGCTGGCCCAGGGCACCATCTACCCGGATGTGATCGAGTCCGCCGGTTC
GGCCACCGGCAAGGCCCATGTCATCAAGTCGCACCACAACGTGGGCGGGCTGCCGGAGGACATGACGCTGAAGCTGGTGG
AGCCGTTGCGCGAGCTGTTCAAGGACGAGGTGCGCCGCATCGGCCTGGAGCTCGGGCTGCCCGCCGACATGGTCTACCGG
CACCCCTTCCCGGGGCCGGGCCTGGGGGTGCGGATCCTCGGCGAGGTGCGCAAGGAGTACGCGGACCTGCTTCGGGAGGC
GGACGCCATCTTTATCGAGGAACTGCGCGCCCACGACCTCTACGACCAGGTTAGCCAAGCCTTTGCCGTCTTCTTGCCCG
TGAAGTCGGTGGGGGTCACCGGCGACGGCCGTCGCTACGAGTACGTGGTGGCGCTGCGGGCGGTGGAGACCATCGATTTC
ATGACCGCACGCTGGGCCCACCTGCCTTACGAGTTCCTGGATCACGTCTCCCGCCGGATCATCAACGAAATACCTGGCAT
CTCCCGGGTGGCGTACGATATCTCCGGCAAACCCCCGGCGACCATCGAGTGGGAGTAA

Protein sequence :
MTQDIHAHRILILDFGSQYTQLIARRVREAGVYCEIYAWDAPETAIRDFGAAGFILSGGPESMTVDNGPRVPEAVFQAGV
PVLGICYGMQAMAGQLGGRVEASDHKEFGYARVRARGHSRLLRDIEDHASPEGWGLLDVWMSHGDRVTGLPPGFKLIAST
ESCPIAGIGDDERGYYGVQFHPEVTHTPQGARILSRFVHEICGCPADWTPGNIVDDLIERVRRQVGGDKVLLGLSGGVDS
SVVAALLHRAIGDQLTCVFVDNGLLRKDEGDQVMATFARHMGVNVIRVDAEARFLEALKGVDDPERKRKIIGNMFIEVFD
EQAARLTEVDWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPEDMTLKLVEPLRELFKDEVRRIGLELGLPADMVYR
HPFPGPGLGVRILGEVRKEYADLLREADAIFIEELRAHDLYDQVSQAFAVFLPVKSVGVTGDGRRYEYVVALRAVETIDF
MTARWAHLPYEFLDHVSRRIINEIPGISRVAYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-127 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-127 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-127 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-114 48