Gene Information

Name : ureC (Tery_0752)
Accession : YP_720654.1
Strain : Trichodesmium erythraeum IMS101
Genome accession: NC_008312
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1210324 - 1212036 bp
Length : 1713 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAGTTATCGTATGAATAGACGGACCTATGCCGAGACCTTTGGTCCAACAGTAGGCGATCGCGTTCGTTTGGCAGATAC
AGAATTATTTATTCAAGTTGAAAAAGATTACACGACCTATGGTGATGAAGTCAAGTTTGGTGGTGGTAAAGTAATTCGTG
ATGGCATGGGACAATCTCCCATATCCCGTGAAGGTGGTGCGGTAGATTTAGTAATTACCAATGCCCTAATTTTAGATTGG
TGGGGTGTGGTCAAAGCGGATATTGGAATTAAAGACGGCAAAATTCATAAAATAGGTAAAGCAGGTAATCCTTATATTCA
AGATCGGGTAGATATTATCATTGGTCCATCTACTGAAATAATTGCCGGAGAAGGACATATTATCACGGCCGGGGGAATAG
ATAGTCATATTCACTTTATTTGCCCTCAACAAATAGAAATAGCGATCGCTTCTGGGATAACAACAATGATAGGAGGTGGC
ACAGGTCCGGCCACGGGTACTAATGCTACAACCTGTACTCCTGGTCAGTGGAATATTTGGATGATGCTGCAAGCTGCCGA
TGCTTTTCCAATGAATTTGGGTTTTTTGGGAAAGGGAAATAGTGCCAAACCAGAAGGGTTAATAGAACAAATTAAAGCTG
GAGCCATGGGTTTAAAACTTCATGAAGACTGGGGAACAACTCCTGCCGCCATAGATACTTGTTTAAGTGTTGCCGATGAA
TATGACGTACAAGTAGCTATCCATACAGATACCCTTAATGAAGCAGGTTTTGTTGAAAATACGATCGCTGCCTTTAAAGA
TCGAGTAATTCATACCTATCATACTGAAGGTGCGGGAGGTGGACATGCACCAGACATTATTAAAGTTTGTGCCCTCAAAA
ACGTATTACCTTCTTCAACTAATCCGACTCGTCCTTTTACAGTCAATACTTTAGAAGAACATCTTGATATGTTAATGGTG
TGTCACCACCTTGATAAAAACATTCCTGAAGATGTAGCTTTTGCTGAATCTAGAATACGTAAAGAAACTATTGCTGCAGA
AGATATTCTGCATGATTTAGGAGCATTTAGCGCTATTGCGTCTGATTCTCAAGCAATGGGTAGAGTGGGAGAAGTTATTA
TTCGTACTTGGCAAACTGCTCACAAAATGAAAGTACAAAGAGGTATTTTAGCTTCTGAGAAAAAGGAAGTAGCAGATAAT
TTTCGTGCTAAACGCTACATTGCTAAATATACTATAAATCCGGCAATTATGCACGGTATTGCTGATTATGTTGGTTCTAT
TGAAGCCGGTAAACTAGCGGATATTTGCCTTTGGAAACCTGCTATGTTTGGGGTCAAGCCCGAAATAGTTATTAAAGGTG
GTGCGATCGCTTGGGCACAAATGGGGGACCCCAATGCTAGTATTCCGACACCCCAACCTGTATATATGCGTCCCATGTTT
GGTAGCTTTGGTGGTGCAACTTCCAGTACTTCTTTAACTTTCGTCTCTCAAGAGGCATTAGACGCTGAGATACCTAAAAA
AATCAATTTAAAAACCCCTGCTGTAGCTGTGAGTAATACACGAAATATTAGCAAGGCAGACATGAAACTAAATGAAGCTA
CACCTAAAATAGAAGTAAACCCTGAAACTTATGAAGTGAGAGCAGATGGTGAACTATTAACTTGTGAACCTGCCTATGTT
TTACCAATGACCCAACGTTATTTTTTATTTTAA

Protein sequence :
MSYRMNRRTYAETFGPTVGDRVRLADTELFIQVEKDYTTYGDEVKFGGGKVIRDGMGQSPISREGGAVDLVITNALILDW
WGVVKADIGIKDGKIHKIGKAGNPYIQDRVDIIIGPSTEIIAGEGHIITAGGIDSHIHFICPQQIEIAIASGITTMIGGG
TGPATGTNATTCTPGQWNIWMMLQAADAFPMNLGFLGKGNSAKPEGLIEQIKAGAMGLKLHEDWGTTPAAIDTCLSVADE
YDVQVAIHTDTLNEAGFVENTIAAFKDRVIHTYHTEGAGGGHAPDIIKVCALKNVLPSSTNPTRPFTVNTLEEHLDMLMV
CHHLDKNIPEDVAFAESRIRKETIAAEDILHDLGAFSAIASDSQAMGRVGEVIIRTWQTAHKMKVQRGILASEKKEVADN
FRAKRYIAKYTINPAIMHGIADYVGSIEAGKLADICLWKPAMFGVKPEIVIKGGAIAWAQMGDPNASIPTPQPVYMRPMF
GSFGGATSSTSLTFVSQEALDAEIPKKINLKTPAVAVSNTRNISKADMKLNEATPKIEVNPETYEVRADGELLTCEPAYV
LPMTQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 2e-154 67
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 2e-154 67
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-152 65
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-153 65
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-153 65
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-153 65

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_720654.1 urease subunit alpha VFG0270 Protein 1e-141 63