Gene Information

Name : guaA (HS_0421)
Accession : YP_718631.1
Strain : Haemophilus somnus 129PT
Genome accession: NC_008309
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 449845 - 451416 bp
Length : 1572 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTAATATTCACCATCACAAAATTTTAATTTTAGACTTCGGTTCACAATATACGCAACTTATCGCACGTCGTGTACG
TGAAATCGGGGTATATTGCGAACTTTGGGCTTGGGACGTTACGGAAGAACAAATTCGTGAGTTTAACCCAACAGGAATTA
TTCTTTCAGGCGGACCGGAAAGTACTACTGAGGCAAATAGTCCACGTGCACCGGAATACGTTTTCAATGCAGGCGTACCT
GTTTTAGGTATTTGCTACGGCATGCAAACCATGGCAATGCAGTTGGGCGGTTTAACAGAAACTTCTACGCATCGTGAGTT
TGGCTATGCTGAAGTTTCTCTACGAAATCCGACCGCACTTTTTGATCATCTCAATGATGATGCGACCACTTCTCAGACTA
CACTTGATGTTTGGATGAGCCACGGCGATAAAGTGACTCGCCTACCTGATAATTTCCAAATTACAGGCATGACCTCGACT
TGCCCGATTGCGGCTATGTCAGATGAAAGCCGTCGTTTCTATGGCGTGCAATTTCACCCCGAAGTTACCCACACAAAGTG
CGGTCAAAAATTACTGCAAAATTTTGTGGTAGATATTTGCGGTTGCGAAACCAATTGGACCGCAGAAAATATCATCGAAG
ATGCAGTGGCTCGCATTAAAGCACAAGTGGGCGGTGATGAAGTAATTTTAGGCTTGTCAGGTGGCGTGGATTCATCTGTT
ACCGCACTTTTATTGCATCGTGCCATCGGTAAAAATTTACATTGTGTCTTTGTCGATAACGGCTTACTCCGTCTAAATGA
AGGCGATCAGGTCATGGAAATGTTCGGTGATAAATTCGGCTTGAATATTATTCGAGTAGAAGCAGAAGATCGCTTTTTAG
AAGCATTAAAAGGAATTGATGAACCGGAAGCAAAACGCAAAACTATCGGTAAAGTATTCGTTGATGTATTCGATGATGAA
GCAAAAAAATTAACTGACGTAAAATGGTTAGCTCAAGGAACGATTTACCCTGATGTTATCGAATCGGCAGCAAGCAAAAC
CGGAAAAGCCCACGTTATCAAATCTCACCACAATGTAGGAGGCTTACCCGATTATATGAAATTAGGTTTAGTTGAGCCAT
TACGTGAACTCTTCAAAGATGAAGTGCGTAAAATCGGCTTGGCACTTGGCTTGCCTGCAGAAATGCTTAATCGCCACCCA
TTCCCAGGCCCTGGATTAGGTGTACGTGTACTGGGTGAAATCAAAAAAGAATATTGCGATTTACTGCGTAAAGCCGATGC
AATTTTTATCGAAGAACTGCATAAAGCAGATTGGTACTACAAAGTCAGCCAAGCGTTCAGTGTTTTCTTGCCGGTAAAAT
CTGTCGGGGTAATGGGCGACGGTCGTAAATATGATTGGGTTATTAGCCTAAGAGCGGTCGAAACCATTGACTTTATGACC
GCACATTGGGCAAACCTACCTTATGATTTATTAGGCAAAATCTCAAATCGCATTATCAACGAAGTCAACAGCATCTCCCG
TGTAGTTTATGACATCTCAGGAAAACCACCAGCAACGATTGAGTGGGAGTAG

Protein sequence :
MTNIHHHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPTGIILSGGPESTTEANSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSTHREFGYAEVSLRNPTALFDHLNDDATTSQTTLDVWMSHGDKVTRLPDNFQITGMTST
CPIAAMSDESRRFYGVQFHPEVTHTKCGQKLLQNFVVDICGCETNWTAENIIEDAVARIKAQVGGDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEGDQVMEMFGDKFGLNIIRVEAEDRFLEALKGIDEPEAKRKTIGKVFVDVFDDE
AKKLTDVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLLRKADAIFIEELHKADWYYKVSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWANLPYDLLGKISNRIINEVNSISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-130 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-130 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-130 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-111 48