Gene Information

Name : cadB (HS_1006)
Accession : YP_719217.1
Strain : Haemophilus somnus 129PT
Genome accession: NC_008309
Putative virulence/resistance : Virulence
Product : lysine/cadaverine antiporter
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0531
EC number : -
Position : 1107112 - 1108428 bp
Length : 1317 bp
Strand : +
Note : antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein

DNA sequence :
ATGAATACAAAAAAAATTGGTTTAGTCGCCTGTATTGCGGTGGTTGCAGGTAATATGATGGGAAGCGGTATAGCACTTCT
TCCTTCAAGTTTAGCTAAGATTGGATCTATTGCTATTTTTGGATGGATAATAGCAATAATAGGAGCTTTAGCACTTGCAT
ATGTTTTTGCTAGACTCAGTACAAAAAATCCTCAAGCTGGAGGACCTGTAGCTTATGCAGGTGAAGTTTCACCTATATTT
GGCTACCAAACATCAATTTTATACTACCACGCAAATTGGATTGGTAATTTAGCTATCGCTATTACTGCCATTGCTTATCT
ATCAACATTTTTTCCTATTTTAAATGAACCTATTCCGGCAGCAATTGCAGCCATATGTGCAGTTTGGTTTTTTACTTTTA
TCAATTTGTTAGGTGGCACATGGGTTAGTCGCTTTACCTCTATAGGATTAATTTTGGTATTAATTCCAGTTGTTGGTACT
GCTTTACTAGGTTGGACACATTTTAACGTGGAAATTTATAAAGCAAACTGGTTGGCTAATCCAGATGTGCATTCCATGAA
AGCAGTGATTAATTCAGTATTGTTATGTTTATGGGCTTTTGTTGGGGTTGAATCTGCTGCAGTGAGTAGCGATTTAGTTG
AGAATCCTAATAAGACAGTTCCTCTAGCCACATTATTAGGTACAGGATTAGCGGGAATTATTTATGTTATGGCATCTCAA
GTAATTTCAGGCATGTTCCCTAATGAAATTACTGCTACATCAGGGGCTCCTTTTGCCTTAAGTGTCTCCGCTATTGTAGG
TGATTGGGCAAGTCCTATTGTATCAGCGTTTACTGCAATAGCTTGTCTTACGTCTTTAGGCTCATGGATGATGTTAGTTG
GACAAGCTGGTAGAAGGGCTGCTGATGATGGTAATTTCCCTAAAATGTTCGGTGAAGTAGATAAGAATGGAACACCAAAA
AAAGGACTATTTGCCGCCTCAATAATGATGACGATTTTGATGATCCTACTTACCATAGTGACAACTAGCGGATCTAGTGC
ATCAGATTTATTCACTCAATTAACCAGCGTAGCTGTTCTCTTAACCATGTTCCCATATTTTTATTCCATTATAGATTTAA
TTCGCTTAGAAGGATTAACTTCTAAAAGCACATTTAGTTTAATTGCCTCAAGTTTAGCAATCCTATTTTGTTTTGCCGCA
CTTGCTGGAGCTGAACATTATCAAATCACAGCAACAATTCTAATCGCTTTATGTATCTTCGCTTTTTATGCAAAGAAATT
AGGTACAAAACAATTACATCAAATAAACAATCATTAA

Protein sequence :
MNTKKIGLVACIAVVAGNMMGSGIALLPSSLAKIGSIAIFGWIIAIIGALALAYVFARLSTKNPQAGGPVAYAGEVSPIF
GYQTSILYYHANWIGNLAIAITAIAYLSTFFPILNEPIPAAIAAICAVWFFTFINLLGGTWVSRFTSIGLILVLIPVVGT
ALLGWTHFNVEIYKANWLANPDVHSMKAVINSVLLCLWAFVGVESAAVSSDLVENPNKTVPLATLLGTGLAGIIYVMASQ
VISGMFPNEITATSGAPFALSVSAIVGDWASPIVSAFTAIACLTSLGSWMMLVGQAGRRAADDGNFPKMFGEVDKNGTPK
KGLFAASIMMTILMILLTIVTTSGSSASDLFTQLTSVAVLLTMFPYFYSIIDLIRLEGLTSKSTFSLIASSLAILFCFAA
LAGAEHYQITATILIALCIFAFYAKKLGTKQLHQINNH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66196.1 putative lysin/cadaverin transporter Virulence PAI III 536 Protein 8e-137 78
cadB NP_756989.1 lysine/cadaverine antiporter Not tested PAI II CFT073 Protein 4e-119 66
cadB AAL67382.1 cadaverine/lysine antiporter Not tested PAI II CFT073 Protein 3e-119 66

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadB YP_719217.1 lysine/cadaverine antiporter VFG1671 Protein 5e-137 78