Gene Information

Name : FRAAL4648 (FRAAL4648)
Accession : YP_714833.1
Strain : Frankia alni ACN14a
Genome accession: NC_008278
Putative virulence/resistance : Virulence
Product : (2,3-dihydroxybenzoyl)adenylate synthase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 5039859 - 5041592 bp
Length : 1734 bp
Strand : -
Note : Evidence 2b : Function of strongly homologous gene; Product type e : enzyme

DNA sequence : 
GTGCTGGCCGGATGCATTCCGTGGCCGGATGAGGCGGCCGAGCGCTACCGGTCACGGGGCCTATGGCGTGGGGAGTCGCT
GGGCGGGCTGCTGCGCACCGCGGCGGAGCGGCACGGGCCGGCTCCCGCCCTGGTGCACGGCGGGCGCCGAATCTCCTATG
CCCAGCTCGACCGTTGGGTCGACCGGCTGGCCGGCGGTTTCGCGGGCCACGGCCTGCGCGCCGGCGAGCGGGTCGTGGTG
CAACTCCCCAACGTGCCGGAGTTCGTGGCCACCTGCTTCGCGTTGTTTCGGCTCGGGGCCAAGCCCGTGTTCGCGCTGAC
GGCGCACCGGTCGCGGGAGATCGCGTACCTGTGCGACATCACCGGCGCCGCCGCCTACGTGTTTCCCGGGCGCCACCGAG
GATTTGATCACCCAGCGCTGGCCCGGGAGATTCGGGCGGGTACACACGGCCTGAGGTTGCTGTTCGCCCTCGGCGACGCG
GGTGACGACCTCATCGATCTGTCCACTGTGGACGGCGAAGCCGGGAGGCTTCCGGAGCAGGACGCATCGGATGTTGCGTT
CTTCCTGCTTTCCGGCGGAACGACGGCCATCCCGAAGATCATCCCGCGCACGCACGACGACTACGCCTACCAGTGCCGCG
CGACGGCGGACCTTATCGGCTTCACCGCGGCGGACGTCTACCTGGCGGTGCTGCCGCTGGAGTTCAACTTCACCTGGGGT
TGTCCCGGCGTCATCGGAACGTTGCTGTCCGGGGGCACCGTCGTGCTGGCAGACGATCCCACCACCGACGACTGCTTCGC
CACGATCGAGCGATGCCGGGTCACCGTGACCTCTCTGGTCCCCACCCTCGCCCAGCTGTGGCTGGAGGCGACGGAGTGGA
ACACCCGTGACCTGTCGAGCCTGCGCCTGGTGCAGCTCGGCGGCGCGCGGCCTGCGCGATCTCTTGTCGAACGGATCGGC
CCCGCCTTCGGCTGCGAGCTGCAGCAGGTCTTCGGCATGGCCGAGGGTCTGCTTACCCTCACCAGGCAGGGCGATCCTCC
GGAGACGGTCCTTGGTACGACTGGCACGCCGCTGTCCGAGGAGGACGAGATTCGGATCGTCGGCGAGGACGAGCGGGATC
TGCCCGGCGGAGAGGTGGGTGAACTCCTTGTCCGCGGGCCGTACACCCTGCGGGGCTACTACCGCGCCGCCGAGCACAAC
ACCCGTGCATTCACGGCCGACGGCTTCTACCGCACCGGTGACCTTGCCCGCCTGACCGCGAACGGCGATCTGGTCATCGA
AGGAAGGATCAAGGACGTCGTGATCCGCGGCGGCAACAAGACCTCGGCGGCGGAGCTGGAGGAACACCTGCTCACCCTTC
CGGGGATACTGCGTGCTGCCGTCGTCGGCCTTCCCGACGAGCTGCTTGGCGAACGAATCGGCGCCTTTCTCGTCACGGCC
GGCACGCGCCCGTCACGGCACGAGCTCAACCAGGGTCTTCAGCAGCGCGGACTGGCCGAGTACAAGTTTCCCGACCAGGT
CGAGTTCGTCGACGAACTCCCCGTCACACCGCTGGGAAAGATCGACAAGAAGGCGTTGGCGTCTATGACCAGCCGGGACC
GGCCATCGACAGCCCACGAGGAGGGCGAACATGGCGACCAATTCCAAGGCAACCACGGACCTGCCGGGCGAGCCGGAGCT
ACGAGAGATGATCGCGAAGTTGATCGGGAGCCCGCCCGAGGACGTCCCGCCTGA

Protein sequence : 
MLAGCIPWPDEAAERYRSRGLWRGESLGGLLRTAAERHGPAPALVHGGRRISYAQLDRWVDRLAGGFAGHGLRAGERVVV
QLPNVPEFVATCFALFRLGAKPVFALTAHRSREIAYLCDITGAAAYVFPGRHRGFDHPALAREIRAGTHGLRLLFALGDA
GDDLIDLSTVDGEAGRLPEQDASDVAFFLLSGGTTAIPKIIPRTHDDYAYQCRATADLIGFTAADVYLAVLPLEFNFTWG
CPGVIGTLLSGGTVVLADDPTTDDCFATIERCRVTVTSLVPTLAQLWLEATEWNTRDLSSLRLVQLGGARPARSLVERIG
PAFGCELQQVFGMAEGLLTLTRQGDPPETVLGTTGTPLSEEDEIRIVGEDERDLPGGEVGELLVRGPYTLRGYYRAAEHN
TRAFTADGFYRTGDLARLTANGDLVIEGRIKDVVIRGGNKTSAAELEEHLLTLPGILRAAVVGLPDELLGERIGAFLVTA
GTRPSRHELNQGLQQRGLAEYKFPDQVEFVDELPVTPLGKIDKKALASMTSRDRPSTAHEEGEHGDQFQGNHGPAGRAGA
TRDDREVDREPARGRPA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-106 48
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-106 48
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 2e-106 48
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-106 48
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-106 48
ybtE CAA21394.1 - Virulence HPI Protein 2e-106 48
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-106 48
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-106 48
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-106 48

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
FRAAL4648 YP_714833.1 (2,3-dihydroxybenzoyl)adenylate synthase VFG0168 Protein 4e-114 49
FRAAL4648 YP_714833.1 (2,3-dihydroxybenzoyl)adenylate synthase VFG1817 Protein 5e-96 46
FRAAL4648 YP_714833.1 (2,3-dihydroxybenzoyl)adenylate synthase VFG0932 Protein 8e-93 41