Gene Information

Name : guaA (FRAAL1150)
Accession : YP_711405.1
Strain : Frankia alni ACN14a
Genome accession: NC_008278
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1218660 - 1220348 bp
Length : 1689 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAGCGAGTTGCAGCGCAGCGATGCTGGTCACGATGTGAGACCGGGGGCCGTGGGCCCGGCGGGGGGCGCCCCGACGGC
GCCGGTGGCCAGGCCCGGCACGCCCGCGGGCGCCGGTGCGCCGGGGCATCCCGGCTACGACACGGTGTTGGTGATCGATT
TCGGCGCGCAGTACGCCCAACTGATCGCCCGACGGGTCCGGGAATGCCATGTGTACTCGGAGATCGTGCCGTGGGACATG
CCCGTGGACGAGATCCTCGCCCGCAGACCGTCCGCACTGATCCTTTCCGGTGGGCCGAAGTCGGTGTACTCGCCGGGAGC
GCCTCGGGTCGACCCTGCGTTGTTCGAGACCGGGCTGCCTATTCTCGGCATCTGCTACGGCCACCAGGTGATGGCCCAGG
CGCTGGCCGGCTCGGTCGCCCGGACTGGAACGGCAGAGTACGGAGCGACTCGCCTGTCGGTGACCGGGCCGGGCGTCCTG
TTCGACGGCCTGCCGGTCGCCCAGCAGGTGTGGATGTCGCACGGCGACTCCGTGACCGCGGCCCCGCCCGGCTTCCGGGT
GACGGCGTCCACCCCGTCGACCCCCGTCGCCGCCTTCGAGGATCCGACCCGCCGCCTCTACGGCGTCCAGTTCCATCCGG
AGGTGGTGCACAGCGAGCGCGGGCTCGACGTGCTGCGGCACTTCCTGCTGGTGGGTGCGGGCTGCCGGCCGACCTGGACC
ATGGTGAACATCGTCGACGAGGCGGTGGCGGCGGTGCGCGCCCAGGTCGGCTCGGGCCGGCTGATCTGCGGGCTGTCCGG
CGGGGTGGACTCCGCGGTCGCCGCGGCGCTCGTGCACCGTGCTGTCGGTGATGCCCTGACCTGCGTTTTCGTTGACCATG
GCCTGCTGCGGGCGGGTGAGGCCGAGCAGGTCGAGCGGGACTTCGTCGCCTCCACCGGCGTCGATCTCGTCCACGTGAAG
GCGGCCGACCGGTTCGCCGCGGCGCTGGCGGGCGTGACCGACCCGGAGCACAAGCGGAAGATCATCGGACGGGAGTTCAT
CCGGGTCTTCGAGGAGTCGGCCCGCGAGCTGGAGGCCCGCGCCGAGGCCGAGGGTGCGACGATCGAGCACCTCGTGCAGG
GGACGCTGTACCCCGACGTGATCGAGTCCGGTTCCCCGACCGCGGCGAAGATCAAGTCGCACCACAACGTCGGCGGCCTG
CCGGAGGACCTGCGGTTCGGCCTGGTCGAGCCGTTGCGCACCCTGTTCAAGGACGAGGTGCGCCGCCTCGGTGAGGAGCT
CGGCCTGCCCGAGGAGATCGTCTGGCGCCAGCCGTTCCCCGGCCCTGGACTCGCCGTCCGCATCATCGGTGAGGTCACCC
CCGAGCGGCTCGACGTGGTCCGGGCGGCCGACGAGGTGGTCCGCGACGAGATCCGCCGGGCCGGCCTGGACCGGGAGATC
TGGCAGGTCTTCGCGGTGCTGCTCGCGGACGTGCGGTCGGTCGGCGTGCAGGGCGACGAGCGCACGTACGGGCACCCGGT
GGTGCTGCGCGCGGTCACCAGCGAGGACGCGATGACCGCCGACTGGGCGCGGCTGCCCTACGGGCTGCTCGAACGGATCT
CCAACCGGATCGTCAACGAGGTGGGACAGGTCAACCGGGTCGTCTACGACATCACCTCGAAGCCCCCGGGCACCATCGAG
TGGGAGTAG

Protein sequence :
MSELQRSDAGHDVRPGAVGPAGGAPTAPVARPGTPAGAGAPGHPGYDTVLVIDFGAQYAQLIARRVRECHVYSEIVPWDM
PVDEILARRPSALILSGGPKSVYSPGAPRVDPALFETGLPILGICYGHQVMAQALAGSVARTGTAEYGATRLSVTGPGVL
FDGLPVAQQVWMSHGDSVTAAPPGFRVTASTPSTPVAAFEDPTRRLYGVQFHPEVVHSERGLDVLRHFLLVGAGCRPTWT
MVNIVDEAVAAVRAQVGSGRLICGLSGGVDSAVAAALVHRAVGDALTCVFVDHGLLRAGEAEQVERDFVASTGVDLVHVK
AADRFAAALAGVTDPEHKRKIIGREFIRVFEESARELEARAEAEGATIEHLVQGTLYPDVIESGSPTAAKIKSHHNVGGL
PEDLRFGLVEPLRTLFKDEVRRLGEELGLPEEIVWRQPFPGPGLAVRIIGEVTPERLDVVRAADEVVRDEIRRAGLDREI
WQVFAVLLADVRSVGVQGDERTYGHPVVLRAVTSEDAMTADWARLPYGLLERISNRIVNEVGQVNRVVYDITSKPPGTIE
WE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-145 65
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-132 54
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-132 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-131 54