Gene Information

Name : metB (RHA1_ro05845)
Accession : YP_705780.1
Strain : Rhodococcus jostii RHA1
Genome accession: NC_008268
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 6285525 - 6286697 bp
Length : 1173 bp
Strand : +
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGAGTGAGCAGCGCAGCAAAGCGGACAACATCAGCTGGCAGGGGTTCTCCACCAAGGCCGTGCACGCAGGATTCGACCC
GGACCCGCAGACGGGCGCCGTCAACGTCCCGATCTACGCGAGTTCGACGTTCGCGCAGGACGGCGTCGGCGGCATGCGAA
ACGGATTCGAATACGCCCGCACCGGCAACCCCACCCGACGACCGCTCGAGGCCAACCTCGCCGCCCTCGAGTCGGGCACG
TACGGTCGCGCCTTCGGCTCGGGCATGGCCGCCACCGACTGCCTGCTCCGTGCCGCGCTCCGCCCCGGCGACCACCTCGT
CATCCCGAACGACGCCTACGGCGGAACGTTCCGCCTGATCGACAAGGTCTTCACCCAGTGGGGCATCGAGTACACGCCCG
CCGCGGTGTCCGACGTGGACGCCGTCCGGGCAGCCATCCGCCCCAACACCAAGCTCGTGTGGGTCGAGACGCCCACCAAC
CCGCTCCTCAACATCGGTGACATCGAGGCACTGTCCGACGTCGCGCACGAGGCAGGAGCGAAGATCGTCGTCGACAACAC
GTTCGCCTCGCCGTACCTGCAGCAGCCGCTGCAGCTCGGCGCCGACGTCGCGCTGCACTCGACCACCAAGTACATCGGCG
GACACTCCGACGTCGTCGGTGGCGCACTCGTCACCAACGACGAGGAGCTCGACACGGCGTTCGCGTTCCTGCAGAACGGT
GCGGGCGCGGTCCCCGGACCCTTCGACGCGTTCCTCACGCTCCGCGGCATCAAGACCCTCTCCCTGCGCATGGAGCGGCA
CAGCGACAACGCCGAGAAGGTCGTCGAACTGCTCACCGGGCACCCCGCGGTGTCCCAGGTCATCTACCCCGGACTCGAGT
CGCATCCCGGCCACAAGGTCGCGGAGAAGCAGATGCGCCGCTTCGGCGGCATGATCTCGGTCCGCCTCGCAGGCGGCAAG
CAGGCTGCGCTGGACTTCTGCTCGCGCACCGAGATCTTCACGCTGGCCGAGTCGCTCGGCGGTGTCGAGTCGCTGATCGA
GCACCCGGGCGCCATGACCCACGCCTCGACCGCCGGTTCGCTGCTCGAGGTCCCGGACGACCTGGTGCGCCTGTCCGTCG
GCATCGAGGATGCCGCCGACCTCGTTGGCGACATCGAGCAGGCACTGAAGTAG

Protein sequence :
MSEQRSKADNISWQGFSTKAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGMRNGFEYARTGNPTRRPLEANLAALESGT
YGRAFGSGMAATDCLLRAALRPGDHLVIPNDAYGGTFRLIDKVFTQWGIEYTPAAVSDVDAVRAAIRPNTKLVWVETPTN
PLLNIGDIEALSDVAHEAGAKIVVDNTFASPYLQQPLQLGADVALHSTTKYIGGHSDVVGGALVTNDEELDTAFAFLQNG
AGAVPGPFDAFLTLRGIKTLSLRMERHSDNAEKVVELLTGHPAVSQVIYPGLESHPGHKVAEKQMRRFGGMISVRLAGGK
QAALDFCSRTEIFTLAESLGGVESLIEHPGAMTHASTAGSLLEVPDDLVRLSVGIEDAADLVGDIEQALK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-77 48
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-76 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-58 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_705780.1 cystathionine gamma-synthase BAC0207 Protein 8e-65 42