Gene Information

Name : clpC (CPR_2437)
Accession : YP_699699.1
Strain : Clostridium perfringens SM101
Genome accession: NC_008262
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence MecB/ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : 3.4.21.-
Position : 2654458 - 2656902 bp
Length : 2445 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGCGTCTTGATAATTTTAATGAAAATTCCAAAATAGTAATCAATAAGGGAAAAGAAAGTTCTTTAATGCTAAAACACGG
CTACATGGGAACAGAGCATTTATTAATAGGATTAATTAATGAAAATGGACAATGTTCTAAAATTTTGGAAGAAAGCAATG
TAACTGAAGAAAAGGTACTTAGTTTTATTAAGCTATATGTTGGAATTGGAGAGGTAAATTATAGTTTAGATGAGGTGCCT
TTTACACCTAGATGCAAAAATATTTTAGATAGAAGTGTTGAAATTGCTAAGGAATATGGTCATAGCATTTCAAGACCAGA
GCACATATTATTAGCTTTAATAAAAGAAAAAGAAGGTGTAGCTAATTTAATTCTAACTAAAATAGTAAAAAATGATATAA
AAAATATAAGTGATAAGTTAAATAATATACTAGGTAGAATTCCAAGTAAGGAAAGTAAAAGCCTTAAAGAAAAAGAAAAA
CCAAAAAGAAAAGATACTCCTACATTAAATCTTTATGGTATAAATTTAATAGAAAAGGCAGATAAAAATAAACTTGATCC
TGTAATAGGAAGAAAAGATGAAACTCAAAGGCTTTTAGAAATACTTTGTAGAAGAATGAAAAACAACCCTTGTTTAATAG
GAGAACCTGGAGTAGGAAAAACTGCCGTTGTGGAGGGCTTAGCTCAAAGAATTCTATTAGGTGAAGTACCAGATATTATT
AAGGATAAAAGAATATTTACCTTAGATGTGACTTCTATGTTAGCTGGGGCAAAATATAGAGGAGAATTTGAGGAAAGACT
TAAAAAGGTTTTAAAAGAGGTAAAAGATTCAGATGATATAATACTCTTTATAGATGAAATGCATAATATTGTTAGGGCTG
GGGGAGCAGAAGGTGCTATAGATGCATCAAATATATTAAAACCAGCTTTAGCAAGAGGTGAAATACAATGTATAGGTGCG
ACAACAACTGATGAATATAGAAAAAATATAGAAAAGGATTCTGCTTTAGAGAGAAGATTCCAACCAGTAGTTGTAAAAGA
GCCTAGTAAAGAAGATTCCGTATTAATATTAAAGGGATTGAGAGAAAAGTACGAAGTACATCACAATGTAAAATTAACAG
ATGAAGCCATAGAGGCAGCTGTTAATTTATCAAGTAGATATATAACAGATAGATTTCTACCAGATAAGGCCATAGATCTA
ATAGATGAGGCTGCGGCAAAGGTAAGAATAGAAAGTATGATTGTCCCTCCTAGACTTTTTAAGCAGGAAGAATTAATAGC
TAACTTAAAAATTGAAAAAGAAGAAGCTATAAAATTACAGGACTTTGAATTAGCTGCAAAGTTAAGAGATGAAGAATCAA
TGTTACAGGAAGAACTAGAGCGAGATAAAGAACTTTGGAGAGAAGAAAATTATAATAAGATTTATGAAGTTAATAAAGAA
CATATTGCAAAGGTTGTTTCAAAGTGGACTCAGATACCAGTAGAAAGGCTTACAGAGAAAGAATCAAGTAAACTTCTTAA
GCTAGAAGAAAAGCTTAGTAAAAGAGTTATAGGACAATTAGAAGCAATAAAAACCATATCAAAGGCTGTAAGAAGATCAA
GGGTAGGTCTTAAAGATCCTAAGAGACCTATTGGATCCTTTGCCTTTTTAGGACCTACTGGAGTAGGAAAAACAGAGCTT
TGTAAGGCTTTAGCAGAGGCTATGTTTGGTGATGAGAATAAATTTATTAGGCTTGATATGTCTGAATATATGGAAAAGCA
TGGTGTATCTAGACTTATTGGAGCCCCTCCAGGGTATGTTGGATATGAAGAGGGAGGACAACTTACAGAAAAGGTAAGAA
GAAATCCTTATTCAGTAATACTTTTTGATGAAATAGAGAAAGCGCATCCAGATATATTTAATATTCTTCTTCAAATATTA
GAAGATGGTGTTCTTACAGATGGAAAAGGTAAAACTGTAGATTTTAAGAATACAATAATCATAATGACTTCAAATATTGG
AGCAGATAAATTAGATAAGAAAAATGCAGTTGGATTTAGTGCTAAAGAGGATAAGGAACGAGATTATGATAAAATGAAAG
GAATTATGTTAGAAGAGCTTAAACAAAATTTTAAACCTGAATTTGTAAATAGATTAGATGACATAGTTGTATTCCATAGT
CTAGAAAAGGATCATCTTTTAAAAATTGTTGATCTTATGATATGTTCTCTAAAAGAAAGATTAAATGATTTGCAACTCTC
TTTGAATTTTTCTCAAGAGTGTAAAGAATTTTTAGTTAAAAAGGGTACTGAATTAAAATATGGAGCACGTCCACTTAGAA
GAGTTATAACTAAATATATTGAAGATAGATTAAGCGAAGAACTTTTAAGTGGAAATATATTAAGAGGATCTAAGGTAGAT
GTTTTCTTAGAAGACGAAGTTGTAAAATTTAAAAAAACTGTTTGA

Protein sequence :
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVLSFIKLYVGIGEVNYSLDEVP
FTPRCKNILDRSVEIAKEYGHSISRPEHILLALIKEKEGVANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEK
PKRKDTPTLNLYGINLIEKADKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLKEVKDSDDIILFIDEMHNIVRAGGAEGAIDASNILKPALARGEIQCIGA
TTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGLREKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDL
IDEAAAKVRIESMIVPPRLFKQEELIANLKIEKEEAIKLQDFELAAKLRDEESMLQEELERDKELWREENYNKIYEVNKE
HIAKVVSKWTQIPVERLTEKESSKLLKLEEKLSKRVIGQLEAIKTISKAVRRSRVGLKDPKRPIGSFAFLGPTGVGKTEL
CKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYVGYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNILLQIL
EDGVLTDGKGKTVDFKNTIIIMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYIEDRLSEELLSGNILRGSKVD
VFLEDEVVKFKKTV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_699699.1 negative regulator of genetic competence MecB/ClpC VFG0079 Protein 0.0 53
clpC YP_699699.1 negative regulator of genetic competence MecB/ClpC VFG0080 Protein 2e-142 53