Gene Information

Name : guaA (CPR_2260)
Accession : YP_699536.1
Strain : Clostridium perfringens SM101
Genome accession: NC_008262
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2479246 - 2480775 bp
Length : 1530 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGAGATTTAGTTTTAGTTGTCGACTTTGGTGGACAATATAATCAATTAATAGCTAGAAGAGTTAGAGAGTGTGGAGT
TTATTGTGAAATAATACCTTACACATATAGCATAGAAAAAATAAAAGAAAAGAATCCAAAAGGAATAATATTCACTGGTG
GACCAAACTCAGTTTACGGAGAAAACACTCCTACATTAGATAAAGAAATATTCAACTTAAATGTTCCTATATTAGGAATA
TGTTATGGAGATCAATTAATGGCACACCTTTTAGGTGGAAAAGTTGCTACTGCTCCAGTAAGAGAATATGGAAAAACTAA
TGTAACTTTAGATAATTCATCAAAATTATTTGCAGGAATAGAAGCAGATGAAACTTGTTGGATGAGTCATACTGATTACA
TAGCAGAAGCACCAGAAGGATTCAAAATCATAGCTCATACAGATGTTTGTCCAGTAGCGGCTATGGAAAATGAAGAAAGA
AGACTTTATGGAGTTCAATTCCATCCAGAAGTTGAGCACACTCCATTTGGTCAAAACATGATGAGAAATTTCCTTTACAA
TATATGTGGATTAGAAAATTCTTGGTCAATGGCTTCTTTTGCAGAAGAAAAAATAGCTGAAATCAAGAAAATAGTTGGAG
ATAAAAAATTAATATGTGCATTATCAGGTGGGGTTGATTCATCAGTTGCAGCTGTTATGGTTCACAAGGCTGTAGGTAAG
CAATTAACTTGTATCTTTGTTGACCACGGTCTATTAAGAAAAGATGAAGGAGATCAAGTAGAAAAAATCTTCAAAGAAGG
TTTTGATATGAACCTTATCAGAGTTAATGCTCAAGATAGATTCTTAGGTAAATTAAAAGGAGTTTCAGATCCAGAAACTA
AGAGAAAGATAATCGGAGAAGAATTCATAAGAGTATTTGAAGAAGAAGCAGGAAAATTAGGAGATATTAAATTCTTAGTT
CAAGGAACAATTTATCCAGACGTTGTTGAAAGTGGAACAGATACTTCAGCAGTAATTAAGAGTCACCACAACGTTGGAGG
ACTTCCAGAAGATATGGAATTCTCATTAATAGAGCCATTAAGAGAATTATTCAAAGATGAAGTAAGAGCTGTAGGAGAAG
AATTAGGAATTCCTCACCACTTAGTATGGAGACAGCCATTCCCAGGACCAGGATTAGCTATAAGAGTTTTAGGAGAAGTA
ACTGAAGATAAATTAGAAGTTGTTAGAGAAGCTGACGCTATATTTAGAGAAGAAATAGCTTTAGCAGGTCTTGAAAGTGA
AATATGGCAATACTTCGCAGTATTACCTAACATTCAATCAGTTGGTGTTATGGGAGACGAAAGAACTTACTGCCACACTG
TAGGATTAAGAGCAGTTACATCATCAGATGGAATGACTTCAAACTGGGCTCATATACCATATGAAGTTATAGATAAGGTT
TCAAGAAGAATTGTAAATGAAGTTAAGGGAGTTAACAGAATTGTTTACGATGTAACTTCAAAACCACCAGCAACTATCGA
GTGGGAATAA

Protein sequence :
MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYGENTPTLDKEIFNLNVPILGI
CYGDQLMAHLLGGKVATAPVREYGKTNVTLDNSSKLFAGIEADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEER
RLYGVQFHPEVEHTPFGQNMMRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGK
QLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGEEFIRVFEEEAGKLGDIKFLV
QGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPLRELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEV
TEDKLEVVREADAIFREEIALAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKV
SRRIVNEVKGVNRIVYDVTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-165 66
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-165 66
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-165 66
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-145 55