Gene Information

Name : guaA (Meso_0495)
Accession : YP_673063.1
Strain : Chelativorans sp. BNC1
Genome accession: NC_008254
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 549263 - 550822 bp
Length : 1560 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCATTACCCATCCCGACACTGTTCTGATCATCGATTTCGGCAGCCAGGTCACGCAGCTGATCGCCCGGCGCGTCCG
CGAGGCCGGCGTCTATTCCGAAATTGCTCCCTTTCAGTCAGCCGAAGAGGCTTATCTGCGGCTCAAGCCGAAGGCGGTCA
TCCTTTCCGGCAGCCCGGCCTCGACCGTCGAGATCGACAGTCCTCGTGCGCCCGATGTGATTTTCCAGTCAGGCGTGCCG
GTTCTCGGTATCTGCTATGGCGAGCAGACCATGTGCGCCCAGCTCGGCGGCAAGGTCGAATCCAGTGATCATCGCGAGTT
CGGCCGCGCCTTCCTCGAGATCGAGGAGGATTGCGGGCTGTTCGCCGGCATCTGGGCGCCCGGCACGCGCCATCAGGTCT
GGATGAGCCATGGCGACCGCGTGACGGCGCTTCCGCCCGGCTTTAAGGTTGTCGGAACTTCAGCGGGCGCGCCTTTTGCG
GCCATCGCCGACGATAAGCGCAAATATTACGGTGTGCAGTTCCATCCGGAAGTGGTCCACACACCCGATGGCGCAAAGCT
GCTTGCCAACTTCGTTCACAGGATCGCGGGCCTTAAGGGCGATTGGACCATGGCCGCTTATCGCGAACAGGCGGTGGATG
CGATCCGCGCCCAGGTTGGTTCCGGCAAGGTGATCTGTGCGCTCTCCGGCGGCGTCGATTCCTCCGTCGCCGCGCTTCTC
ACCCATGAGGCGGTGGGAGAGCAGCTCACCTGCATCCTTGTCGACCATGGCCTGATGCGCAAGAACGAGGCGGCGGAAGT
GGTCTCCATGTTCCGCGAGCACTATAATGTGCCGCTCGTGCTGGTCGATGCTTCCGACCGTTTCCTAAGCGCGCTCGAGG
GTGAAACCGATCCCGAGAAGAAGCGCAAAACGATCGGCCGTCTCTTCATTGAGGTGTTCGAGGACGAGGCAAAAAAGCTG
GGTGGCGCTGATTTTTTGGTGCAGGGCACGCTCTATCCGGACGTGATCGAGAGTGTCTCCTTCACGGGCGGCCCCTCGGT
CACCATCAAATCGCACCACAATGTGGGCGGCCTGCCCGAGCGCATGAACATGAAGCTGGTCGAGCCGCTGCGCGAGCTCT
TCAAGGACGAGGTGCGGGTGCTCGGCAGGAAGCTCGGCCTGCCCGACCATTTCATCGGCCGTCATCCCTTCCCGGGCCCC
GGCCTTGCCATCCGCTGTCCCGGCGGGATCACGCGCGAGAAGCTCGAAATCCTGCGCGCGGCCGACGCCATTTACCTCGA
CGAGATCCGCAAGTCGGGCCTTTACGACGCGATCTGGCAAGCCTTCGCCGTGCTTTTGCCGGTACAGACCGTCGGGGTGA
TGGGAGACGGCCGCACCTATGAATATGTCTGCGCGCTTCGCGCGGTGACGTCAGTCGATGGCATGACGGCTGATTTCTAT
CACTTCGACATGGAGTTCCTTGGCCGCGCCGCCACCCGCATCATCAACGAAGTGCGCGGGATCAATCGCGTGGTCTACGA
TGTGACGTCCAAGCCACCTGGGACTATCGAGTGGGAGTAA

Protein sequence :
MTITHPDTVLIIDFGSQVTQLIARRVREAGVYSEIAPFQSAEEAYLRLKPKAVILSGSPASTVEIDSPRAPDVIFQSGVP
VLGICYGEQTMCAQLGGKVESSDHREFGRAFLEIEEDCGLFAGIWAPGTRHQVWMSHGDRVTALPPGFKVVGTSAGAPFA
AIADDKRKYYGVQFHPEVVHTPDGAKLLANFVHRIAGLKGDWTMAAYREQAVDAIRAQVGSGKVICALSGGVDSSVAALL
THEAVGEQLTCILVDHGLMRKNEAAEVVSMFREHYNVPLVLVDASDRFLSALEGETDPEKKRKTIGRLFIEVFEDEAKKL
GGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRVLGRKLGLPDHFIGRHPFPGP
GLAIRCPGGITREKLEILRAADAIYLDEIRKSGLYDAIWQAFAVLLPVQTVGVMGDGRTYEYVCALRAVTSVDGMTADFY
HFDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-132 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-133 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-133 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-115 50