Gene Information

Name : folA (FTF0312c)
Accession : YP_666493.1
Strain : Francisella tularensis FSC 198
Genome accession: NC_008245
Putative virulence/resistance : Unknown
Product : dihydrofolate reductase type I
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : 1.5.1.3
Position : 327717 - 328217 bp
Length : 501 bp
Strand : -
Note : Similar to Q9K7B6 Dihydrofolate reductase from Bacillus halodurans (163 aa). FASTA: opt: 465 Z-score: 598.3 E(): 2e-25 Smith-Waterman score: 465; 41.566 identity in 166 aa overlap

DNA sequence :
ATGATCTCACTAATCGTTGCTTATGATAAAAACTTTGGTATAGGTAAAGAAAATACTCTAGCATGGAAACTATCAGAAGA
TCTTAAGAACTTTAAAAAAATAACAGAAAACAACTATATTGTTATGGGTAGAAAAACCTTTGAATCGATTGGTCGCCCAC
TACCGAATCGTAAAAATATTATTTTAACTAGAGACAAAGATTACAAACAAGATAAATGTTTAATAATAAATAGTACTCAG
GATATTTTAAATTTTGCTGAATCAAAACCACACTACGAAATATTTATAATCGGTGGTGCACAGATCTATAAAGAATTTCT
AAAATACGCAGATAGATTGTATATAACCGAAGTTGATGCAGAAATGACTGATCTTGATGCTTTCTTTCCACAATGGGATA
AATCAAAATATAAACGTATTGGTCACAAACAATTCAAAAAAGATGATAAAAATGAGTTTGACTTTACATTTAGCGTCTTT
GAAAAAAATAAAAATTTGTAA

Protein sequence :
MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNIILTRDKDYKQDKCLIINSTQ
DILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDAEMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVF
EKNKNL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
folA-2 YP_189146.1 dihydrofolate reductase Not tested ¥ÕSP¥â Protein 2e-20 41