Gene Information

Name : dnaB (FTF1059c)
Accession : YP_667172.1
Strain : Francisella tularensis FSC 198
Genome accession: NC_008245
Putative virulence/resistance : Unknown
Product : replicative DNA helicase
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0305
EC number : -
Position : 1068078 - 1069475 bp
Length : 1398 bp
Strand : -
Note : Similar to DNAB_PASMU (Q9CNL6) Replicative DNA helicase from Pasteurella multocida (467 aa). FASTA: opt: 1484 Z-score: 1719.2 E(): 7.2e-88 Smith-Waterman score: 1484; 51.016 identity in 443 aa overlap.

DNA sequence :
TTGATGTCTATGGATTATCAGTTTAAAGCTGCTGAAACGACTTACTCTCTAGAAGCAGAAAAAGCTATCTTAGGGAATAT
ATTACTGTACAATCAAAATATTGAGTTAGTTGAAGATTTTCTTTTGATTGATGATTTTTTTGATAAAAGACATAAAACCA
TCTATAAACAGATTGTCACGCTTAACCAAGCAAACACTCCGTTTGATGTACTAATTTTAAGTGAATACCTTGCCACCGAG
GGACTTTTAGAACAAGCAGGTGGTGAGGCTTACATCATAGATTTAGCTGCTAATACACCTTCAATATCAAATATCAAGAC
GTACGCTAATATCGTAAAAAATAAGGCTAAGCTTAGAAGTTTACAAAATAGTGTAAATGATATCGTTCAGAAGATATATT
CAGCAGATTCAAAAAATCCTGATGAAGTTATTGATTACGCTGAGAGCAGAATACTTGATGTAGCTAAAGAGCGTGAAACA
CTTACCAAAGGTCCTGAATCGATAAAGTCTGTAATCCCAAAGCTTGTAGATAGAATGAGTGCTATAGTTGATTCTGGTAG
TGGTCTAACAGGGCTTTCAACAGGTTTTATAGATCTTGATAAAATGACATCAGGATTACAAAGAGCAAATATGGGTATCA
TAGCAGCTCGACCATCTATGGGTAAGACTGTTTTGGGTATTAACATCGCTCAAAATGTCGCAAAAATTGCTGATAAGCCA
GTATTAGTTTTTAGTCTAGAGATGCCGTCAGAAGATATTGTAACAAGGATGTTAGCTTCACAGGCGCGTGTAGAGATGAA
TTTATTTAAAGAATGTAATAGGTTAAATGATGCGCATTGGGTTAAAATCACCAGCGCTATGAAAACTTTAAGTGAAATGC
CACTATATATTGATGATACATCAAGTTTGACTCCAGCCGAGATGCGTTCAAGAGCGCGAAGATTATATAATGAGCATGGT
GGTTTAGCAATGATCTTGATAGATTATCTACAGCTTATGAAAATCCCAGGTTATGAGACTAACCGAACACTAGAGGTATC
AGAGATATCCCGTTCACTGAAGGCTTTAGCCAAAGAGTTGGATATACCAGTCATAGCACTATCGCAACTAAATAGAGCAG
TAGATGATCGTAAAGATAAACGACCAATGATGTCAGACTTAAGAGAATCAGGAGCAATTGAACAAGATGCTGACTTGATT
ATGTTTATTTATCGTGATGAAGTTTATAATAAAGATAAAGAAGATAATAAAAATCTAGGTGAAATAATAATAGGTAAGCA
GCGTAATGGTCCTATAGGAACTGTGCATGTGCGCTTTGATGGTCAGTTTGCTAGTTTTGCTAATTTAACTAATGAAAATG
ATCATATTTTACCTGGTGATATAGGTTATAACGAGTAA

Protein sequence :
MMSMDYQFKAAETTYSLEAEKAILGNILLYNQNIELVEDFLLIDDFFDKRHKTIYKQIVTLNQANTPFDVLILSEYLATE
GLLEQAGGEAYIIDLAANTPSISNIKTYANIVKNKAKLRSLQNSVNDIVQKIYSADSKNPDEVIDYAESRILDVAKERET
LTKGPESIKSVIPKLVDRMSAIVDSGSGLTGLSTGFIDLDKMTSGLQRANMGIIAARPSMGKTVLGINIAQNVAKIADKP
VLVFSLEMPSEDIVTRMLASQARVEMNLFKECNRLNDAHWVKITSAMKTLSEMPLYIDDTSSLTPAEMRSRARRLYNEHG
GLAMILIDYLQLMKIPGYETNRTLEVSEISRSLKALAKELDIPVIALSQLNRAVDDRKDKRPMMSDLRESGAIEQDADLI
MFIYRDEVYNKDKEDNKNLGEIIIGKQRNGPIGTVHVRFDGQFASFANLTNENDHILPGDIGYNE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dnaB CAI36044.1 replicative DNA helicase DnaB Not tested PPHGI-1 Protein 6e-67 44
dnaB2 YP_001402701.1 replicative DNA helicase Not tested YAPI Protein 1e-76 44
api2 CAF28476.1 putative DNA binding protein with DNA-dependent ATPase activity Not tested YAPI Protein 3e-77 44
unnamed ABR13456.1 replicative DNA helicase Not tested PAGI-5 Protein 4e-76 43
dnaB1 YP_005176258.1 replicative DNA helicase Not tested ICEPmu1 Protein 3e-65 43
dnaB2 YP_001007676.1 putative DNA helicase Not tested YAPI Protein 2e-75 43
PMI2640 YP_002152342.1 DNA helicase Not tested Not named Protein 3e-78 42
t4227 NP_807829.1 DNA helicase Not tested SPI-7 Protein 3e-71 41
STY4522 NP_458617.1 DNA helicase Not tested SPI-7 Protein 3e-71 41