Gene Information

Name : metB (Hac_1464)
Accession : YP_665187.1
Strain : Helicobacter acinonychis Sheeba
Genome accession: NC_008229
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1270532 - 1271674 bp
Length : 1143 bp
Strand : -
Note : catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine

DNA sequence :
ATGCACATGCAAACCAAATTGATCCATGGGGGCATTAGTGAGGACGCAACAACGGGGGCGGTAAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGTCCAAAGGGCTATGAATACTCTCGCTCAGGCAACCCTACGCGCTTTG
CATTAGAAGAACTTATCGCCGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGTTTAGCCGGAATCCACGCT
GTCTTTTCTCTCTTTCAATCAGGCGATCATGTGTTATTGGGCGATGATGTCTATGGGGGGACTTTTCGCTTATTTGACAA
GGTGCTTTCTAAAAATGGGCTTTCTTGCACCATTATAGAGACTAGCGATATACCTCAAATAAAAAAGGCTATTAAACCCA
ACACCAAAGCCCTCTATTTAGAATCCCCTAGTAACCCCTTGCTTAAAATCACGGATTTGAAGCAATGTGCAAGTCTTGCT
AAAGCTCATGGTCTGCTCACTATCGTGGATAACACCTTTGCCACGCCTTATTACCAAAACCCTCTTCTTTTGGGAGCGGA
CATTGTAGTGCATAGCGGCACAAAATATTTAGGCGGGCATAGCGATGTAGTCGCTGGGCTTGTAACCACTAATAATGAAG
CACTAGCCCAAGAGATCGCCTTTTTCCAAAACGCTATTGGGGGGGTGCTAGGTCCTCAAGATAGTTGGCTGTTGCAAAGA
GGGATTAAAACGCTAGGATTGCGCATGGAAGCCCATCAAAAAAACGCCCTTTGTGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTAGAGAGGGTTTATTATCCAGGCCTGCCCACTCACCTTAATCACGATCTAGCCAAAGCTCAGATGCGTGGTTTTA
GCGGAATGCTTTCTTTCACCCTCAAAAACGACAACGAAGCAACTCCTTTTGTAGAGAATCTTAAATTATTTATTTTAGGC
GAGAGTTTGGGTGGGGTGGAAAGTTTGGTAGGCATTCCAGTGCTCATGACCCATGCGTGTATCCCTAAAGTGCAACGAGA
AGCTGCAGGGATTAGAGATGGTTTGGTGCGCTTGTCTGTGGGGATTGAGCATGAAAAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAACTAGGCTAA

Protein sequence :
MHMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLFQSGDHVLLGDDVYGGTFRLFDKVLSKNGLSCTIIETSDIPQIKKAIKPNTKALYLESPSNPLLKITDLKQCASLA
KAHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHLNHDLAKAQMRGFSGMLSFTLKNDNEATPFVENLKLFILG
ESLGGVESLVGIPVLMTHACIPKVQREAAGIRDGLVRLSVGIEHEKDLLEDLEQAFAKLG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-103 55
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-104 55
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-75 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_665187.1 cystathionine gamma-synthase BAC0207 Protein 2e-62 42