Gene Information

Name : thyA (RD1_1874)
Accession : YP_682171.1
Strain : Roseobacter denitrificans OCh 114
Genome accession: NC_008209
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1793032 - 1793865 bp
Length : 834 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
TTGCAGCAGTATCACGACGCACTACGCACCATTCTGGAGTGCGGAGAAGAGTCAACGGACCGGACGGGCACCGGCACGAT
CTCCTACTTCGGTATGCAAATGCGCTACCCGCTCTCGGACGGTTTTCCGCTGGTGACGACGAAAAAGCTGCACCTGCGCT
CGATCTTTCATGAGTTGCTCTGGTTTCTCTCAGGGGATACGAACATCCGCTACCTGCAGGACAACGGAGTCTCGATCTGG
GATGAATGGGCCGATGAAAATGGCGACCTCGGACCGGTCTATGGCCACCAGTGGCGTGCGTTTTCTGCGCTTTCGCCGAC
GGAAGAGGTCAAAGATGGCGAGCCCTTGTACCTAGGCCGCGGCGTTGATCAGGTCACAAACCTGATTGACATGATCAAAT
CCAGTCCCGACAGCCGTCGTATGATCGTGTCCGCGTGGAACCCGGCGGATGTGCCGCGTATGGCGCTGCCGCCATGCCAC
GCGTTGTGGCAGGTGCGCGTGCTGAACGGTCGTATGCACCTGCAGCTTTATCAACGCTCCGCCGATATGTTCCTTGGCGT
GCCGTTCAACATCGCGTCCTATTCGTTGCTGCTGGTGATGCTGGCCCATGTCACGGGCTATGAACCGGGTGATTTCGTGC
ACACGCTGGGGGATGCGCATATTTACAGCAACCACATGGATCAGGTGAATTTGCAACTGACGCGGACACCCAAACCGCTG
CCGACACTACGAATAAACAGGCAGGTGAGTTCCATTTTCGACTTCCGCTATGAGGATTTTGAAGTGATCGGCTATGATCC
AGACCCGGCTATACGGGCACCTGTGGCGGTCTGA

Protein sequence :
MQQYHDALRTILECGEESTDRTGTGTISYFGMQMRYPLSDGFPLVTTKKLHLRSIFHELLWFLSGDTNIRYLQDNGVSIW
DEWADENGDLGPVYGHQWRAFSALSPTEEVKDGEPLYLGRGVDQVTNLIDMIKSSPDSRRMIVSAWNPADVPRMALPPCH
ALWQVRVLNGRMHLQLYQRSADMFLGVPFNIASYSLLLVMLAHVTGYEPGDFVHTLGDAHIYSNHMDQVNLQLTRTPKPL
PTLRINRQVSSIFDFRYEDFEVIGYDPDPAIRAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 6e-70 56
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-54 45