Gene Information

Name : YPA_4012 (YPA_4012)
Accession : YP_653918.1
Strain : Yersinia pestis Antiqua
Genome accession: NC_008150
Putative virulence/resistance : Virulence
Product : type III secretion system protein
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4790
EC number : -
Position : 4521532 - 4522242 bp
Length : 711 bp
Strand : -
Note : part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response

DNA sequence : 
ATGCGAAACAGCTTACTTTTTATCTTATCTGAAACAGATGACTTATATGAAACAGATCACATGGAATTACTGAATTCATC
CTATCAATTGATCGCCCTGCTTTTCATGCTGTCCGTGTTGCCTTTACTGGTGGTCATGGGGACCGCATTCCTTAAGCTAT
CCGTGGTTTTTTCGTTGTTACGCAATGCGCTGGGTGTTCAACAAGTGCCACCGAATATTGCCATTTACGGGCTGGCGCTG
GTGCTGACTATTTTTATCATGGCACCGGTTGGTTTAGATGTTCAGGCGCGCTTGCAAAATGAAGAGCTGTCCAATGACAT
CGGCGCATTAGCGCACCAAATTGATCAAAATGCGCTGGTGCCCTACCGCGATTTTTTACAGCGCAATACCGATATTGAGC
AAGTCACTTTTTTTAACGACATTGTGCAGAATAAGTGGCCTGAGCGTTACCGCGATAGCGTCAAACCCGATTCACTGCTG
ATATTAATGCCCGCCTTTACCCTCAGTCAGCTTAATGAAGCGTTTAAAATCGGCCTGTTACTTTTTTTACCGTTTGTCGC
CATCGATTTAATTGTATCCAACATTTTGCTGGCGATGGGCATGATGATGGTGTCACCCATGACCCTGTCATTGCCGTTTA
AACTGTTGGTTTTCGTCCTGGTGGATGGCTGGTCATTGGTTCTCGGACAGCTTGTAGGTTCCTATTTATGA

Protein sequence : 
MRNSLLFILSETDDLYETDHMELLNSSYQLIALLFMLSVLPLLVVMGTAFLKLSVVFSLLRNALGVQQVPPNIAIYGLAL
VLTIFIMAPVGLDVQARLQNEELSNDIGALAHQIDQNALVPYRDFLQRNTDIEQVTFFNDIVQNKWPERYRDSVKPDSLL
ILMPAFTLSQLNEAFKIGLLLFLPFVAIDLIVSNILLAMGMMMVSPMTLSLPFKLLVFVLVDGWSLVLGQLVGSYL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
YPO0270 YP_002345352.1 type III secretion system protein Virulence Not named Protein 2e-88 100
yscR NP_805090.1 type III secretion system protein Virulence SPI-2 Protein 5e-57 60
ssaR YP_216427.1 type III secretion system protein Virulence SPI-2 Protein 1e-57 60
ssaR NP_460384.1 type III secretion system protein Virulence SPI-2 Protein 1e-57 60
ssaR CAA68199.1 secretion system apparatus, SsaR Virulence SPI-2 Protein 8e-58 60
yscR NP_456109.1 putative type III secretion protein Virulence SPI-2 Protein 5e-57 60
lscR AAO18040.1 LscR Virulence TTSS locus Protein 2e-54 60
escR AAK26700.1 EscR Virulence LEE Protein 2e-46 53
escR AAL57527.1 EscR Virulence LEE Protein 2e-46 53
escR CAC81847.1 EscR protein Virulence LEE II Protein 2e-46 53
escR CAI43889.1 EscR protein Virulence LEE Protein 2e-46 53
escR YP_003223490.1 T3SS structure protein EscR Virulence LEE Protein 3e-46 53
escR YP_003232138.1 type III secretion system protein Virulence LEE Protein 3e-46 53
escR ACU09473.1 type III secretion system protein EscR Virulence LEE Protein 2e-46 52
ECs4583 NP_312610.1 type III secretion system protein Virulence LEE Protein 3e-46 52
escR AFO66317.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 2e-44 52
escR YP_003236103.1 T3SS structure protein EscR Virulence LEE Protein 3e-46 52
escR AFO66400.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 2e-44 52
escR NP_290283.1 type III secretion system protein Virulence LEE Protein 3e-46 52
escR AAC38369.1 EscR Virulence LEE Protein 2e-45 52
unnamed AAL06354.1 EscR Virulence LEE Protein 3e-46 52
escR AAC31528.1 L0049 Virulence LEE Protein 2e-46 52
hrcR NP_791222.3 type III secretion protein HrcR Virulence Hrp PAI Protein 8e-35 49
hrcR AAG33884.1 HrcR Virulence Hrp PAI Protein 7e-35 49
hrcR ABQ88359.1 HrcR Virulence Hrp PAI Protein 3e-32 49
hrpW AAB05075.1 HrpW Virulence Hrp PAI Protein 3e-32 49
hrcR AAT96200.1 HrcR Virulence T-PAI Protein 2e-33 49
hrcR AAT96146.1 HrcR Virulence T-PAI Protein 2e-33 49
hrcR AAT96262.1 HrcR Virulence S-PAI Protein 7e-37 48
hrcR AAT96303.1 HrcR Virulence S-PAI Protein 7e-37 48
hrcR AAT96343.1 HrcR Virulence S-PAI Protein 7e-37 48
hrcR ABA47279.1 HrcR Virulence S-PAI Protein 1e-35 48
hrcR AAB06005.2 HrcR Virulence Hrp PAI Protein 1e-37 48
XC_3016 YP_244084.1 type III secretion system protein Virulence Hrp PAI Protein 6e-38 48
hrcR NP_636600.1 type III secretion system protein Virulence Hrp PAI Protein 6e-38 48
hrcR BAB07862.1 HrcR Virulence Hrp PAI Protein 1e-37 47
hrcR AAP34349.1 HrcR Virulence Hrp PAI Protein 2e-37 47
hrcR AAD21321.1 HrcR Virulence Hrp PAI Protein 1e-37 47
hrcR NP_640757.1 type III secretion system protein Virulence Hrp PAI Protein 2e-37 47
hrcR YP_362153.1 type III secretion system protein Virulence Hrp PAI Protein 2e-37 47
hrcR YP_198720.1 type III secretion system protein Virulence Hrp PAI Protein 1e-37 47
spaP YP_217809.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 1e-30 44
spaP NP_461811.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 1e-30 44
spaP NP_806493.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 3e-30 43
spaP NP_457284.1 secretory protein (associated with virulence) Virulence SPI-1 Protein 3e-30 43
spaP AAS66865.1 SpaP Not tested SSR-2 Protein 1e-35 42
spaP NP_311752.1 surface presentation of antigens protein SpaP Not tested LIM Protein 4e-35 41
ysaR AAS66846.1 YsaR Not tested SSR-1 Protein 5e-32 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
YPA_4012 YP_653918.1 type III secretion system protein VFG0519 Protein 5e-58 60
YPA_4012 YP_653918.1 type III secretion system protein VFG0394 Protein 5e-51 57
YPA_4012 YP_653918.1 type III secretion system protein VFG0188 Protein 7e-53 57
YPA_4012 YP_653918.1 type III secretion system protein VFG0715 Protein 1e-45 52
YPA_4012 YP_653918.1 type III secretion system protein VFG0827 Protein 1e-46 52
YPA_4012 YP_653918.1 type III secretion system protein VFG0044 Protein 2e-41 50
YPA_4012 YP_653918.1 type III secretion system protein VFG0551 Protein 5e-31 44
YPA_4012 YP_653918.1 type III secretion system protein VFG1259 Protein 2e-33 44
YPA_4012 YP_653918.1 type III secretion system protein VFG1773 Protein 4e-35 42
YPA_4012 YP_653918.1 type III secretion system protein VFG2338 Protein 3e-28 41
YPA_4012 YP_653918.1 type III secretion system protein VFG2016 Protein 4e-30 41