Gene Information

Name : guaA (Rxyl_0816)
Accession : YP_643596.1
Strain : Rubrobacter xylanophilus DSM 9941
Genome accession: NC_008148
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 851032 - 852552 bp
Length : 1521 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGATCGTCGTACTGGACTTCGGGGGGCAGTACGCCCAGCTCATCGCCCGGCGCGTCCGGGAGGCGCGGGTCTTCAGCGA
GCTGCTGCCCTACGACACCCCGCTGGAGGAGATCCGGCGCCGCGACCCGGAGGGGATCATCCTCTCCGGCGGCCCGAACA
GCGTCTACGAGAGGGGGGCCCCGCGGGTGGACGCGGCCCTCTTCGACCTCGGGGTGCCGGTGCTCGGCATCTGCTACGGG
ATGCAGCTCATGGCCCTGACGCTCGGCGGGGAGGTGGGGGCGGTCCAGATCCGGGAGTACGGCCGCTCGAAGCTCGAGGT
CCGGGGACACGGAGAGCTGTTCTCCGGCACCCCCGACGAGCAGACCGTCTGGACGAGCCACGGCGACGCGGTGCTGGCCG
CGCCGCCGGGCTTCCGGGTGACCGCGCGGACGCCCTCCGTCCCGATACTCGCCTTTGAGGAGCCCTCCAGGGGGCTCTAC
GGGGTGCAGTTCCACCCCGAGGTGCGCCACACCGAGTACGGGATGGAGATCCTGAAGAACTTCCTCTTCGAGGCCTGCGG
CTGCGCGCCGGACTGGACCCCGGTGAACATCGTCACCGAGGCGGTGGAGCGCGTCCGGGAGCAGGTGGGGGCGTCCCGGG
CTATCTGCGCCCTCTCCGGCGGGGTGGACTCGGCCACCGCCGCCATGCTCGTGCACCGCGCCATCGGGGACAAGCTGACC
TGCGTCTTCGTGGACCACGGCCTCTTGCGGCAGAACGAGGCCGAGCAGGTGGTGGAGGCCTTCCGGCGGGAGGCCGGGCT
GCCGCTCGTCCACGTGGACGCGAGGGAGCGCTTTCTGGACCGGCTGGCGGGGGTGACCGACCCGGAGGCCAAGCGCAAGA
TCGTCGGCGAGGAGTTCATCCGGGTCTTCGAGGAGGAGGCCGGGAAGATACGGGACGCCCGCTTTCTCGTGCAGGGGACG
CTCTACTCCGACGTGATCGAGAGCGGCACCCGCGACGCGGCCAGGATAAAGAGCCACCACAACGTCGGGGGCCTGCCGGA
GGTGATGGACCTCGAGCTCGTCGAGCCCCTGCGCAACCTCTTCAAGGACGAGGTGCGGGTGGTCGCCGCCGAGCTCGGGA
TGCCCGAGCGCCTCGTCTGGCGCCAGCCGTTCCCCGGTCCGGGGCTCGCCATCCGGATAATAGGGGAGGTCACCGCCGAG
CGGCTCGAGATCCTGCGCAAGGCCGACGCGGTGCTGCAGGACGAGATCCGCTCGGCGGGCTACTACCGCAGGCTCTGGCA
GAGCTTCGCCGTTTTGCCCGCGGTGCACTCGGTGGGGGTCATGGGCGACGCCCGCACCTACGCCTACCCCATCGTGATCC
GGGCCGTCACCTCCGACGACGCGATGACCGCCGACTGGGCTCGCCTCCCGTACGACCTCCTGGAGCGGATCTCGAACCGC
ATCATCAACGAGGTCCCCGGCGTGAACCGGGTGGCGCTCGACATCACCAGCAAGCCGCCCGGCACGATCGAGTGGGAGTG
A

Protein sequence :
MIVVLDFGGQYAQLIARRVREARVFSELLPYDTPLEEIRRRDPEGIILSGGPNSVYERGAPRVDAALFDLGVPVLGICYG
MQLMALTLGGEVGAVQIREYGRSKLEVRGHGELFSGTPDEQTVWTSHGDAVLAAPPGFRVTARTPSVPILAFEEPSRGLY
GVQFHPEVRHTEYGMEILKNFLFEACGCAPDWTPVNIVTEAVERVREQVGASRAICALSGGVDSATAAMLVHRAIGDKLT
CVFVDHGLLRQNEAEQVVEAFRREAGLPLVHVDARERFLDRLAGVTDPEAKRKIVGEEFIRVFEEEAGKIRDARFLVQGT
LYSDVIESGTRDAARIKSHHNVGGLPEVMDLELVEPLRNLFKDEVRVVAAELGMPERLVWRQPFPGPGLAIRIIGEVTAE
RLEILRKADAVLQDEIRSAGYYRRLWQSFAVLPAVHSVGVMGDARTYAYPIVIRAVTSDDAMTADWARLPYDLLERISNR
IINEVPGVNRVALDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-142 59
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-153 57
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-154 57
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-154 57