Gene Information

Name : thyA (Mmcs_2112)
Accession : YP_639276.1
Strain : Mycobacterium sp. MCS
Genome accession: NC_008146
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2259946 - 2260746 bp
Length : 801 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
GTGCCGATCCCCACGCCCTACGAGGATCTGCTGCGTCTCGTATTCGAGCGCGGCACCCCCAAATCGGACCGCACCGGAAC
CGGCACCCGCAGCCTGTTCGGTCACCAGATGCGCTATGACCTCGCCGCGGGGTTCCCGTTGATCACCACCAAGAAGGTGC
ACCTCAAATCGGTGGTGTACGAGCTCCTGTGGTTCCTGCGGGGTGAGTCCAACGTGCGCTGGCTGCAGGAGCACGGCGTC
ACGATCTGGGACGAATGGGCCAGCGAGACCGGTGAGCTCGGCCCCGTCTACGGCGTGCAGTGGCGGTCGTGGCCGACCCC
GTCGGGCGGGCACGTCGACCAGATCAGCGCGGCCGTCGACCTGCTGCGGACCGACCCGGACTCGCGCCGCAACATCGTCT
CGGCGTGGAATGTGGGGGAGATCCCGCAGATGGCGCTGCCGCCGTGCCATGCGTTCTTCCAGTTCTACGTCGCCGACGGC
CGGCTCTCCTGCCAGCTGTACCAGCGCAGTGCCGACCTCTTCCTCGGCGTGCCGTTCAACATCGCCAGCTATGCGTTGCT
CACCCACATGATGGCCGCGCAGGCCGGACTGGGTGTCGGTGAGTTCGTGTGGACCGGCGGCGACTGCCACATCTACGACA
ACCACGTCGAGCAGGTCACCGAGCAGCTCTCCCGCGACCCTCGCCCGTATCCGGAACTCGTTCTCGCGCAACGAGATTCA
ATATTCGACTACACCTACGAGGACGTCGTCGTCAAGAACTACGATCCGCACCCGGCGATCAAAGCCCCGGTGGCGGTATG
A

Protein sequence :
MPIPTPYEDLLRLVFERGTPKSDRTGTGTRSLFGHQMRYDLAAGFPLITTKKVHLKSVVYELLWFLRGESNVRWLQEHGV
TIWDEWASETGELGPVYGVQWRSWPTPSGGHVDQISAAVDLLRTDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADG
RLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFVWTGGDCHIYDNHVEQVTEQLSRDPRPYPELVLAQRDS
IFDYTYEDVVVKNYDPHPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-96 71