Gene Information

Name : ureB (HPAG1_0073)
Accession : YP_626814.1
Strain : Helicobacter pylori HPAG1
Genome accession: NC_008086
Putative virulence/resistance : Virulence
Product : urease subunit beta
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 73205 - 74914 bp
Length : 1710 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureA(alph

DNA sequence :
ATGAAAAAGATTAGCAGAAAAGAATATGCTTCTATGTATGGCCCTACTACAGGCGATAAAGTGAGATTGGGCGATACAGA
CTTGATCGCTGAAGTAGAACATGACTACACCATTTATGGCGAAGAGCTTAAATTCGGTGGCGGTAAAACTTTAAGGGAAG
GCATGAGCCAATCCAACAACCCCAGCAAAGAAGAGCTGGATCTAATCATCACTAACGCTTTAATCGTGGATTACACCGGT
ATTTATAAAGCGGATATTGGTATTAAAGATGGCAAAATCGCTGGCATTGGTAAAGGCGGTAACAAAGATATGCAAGATGG
CGTTAAAAACAATCTTAGCGTGGGTCCTGCTACTGAAGCCTTAGCCGGTGAAGGTTTGATCGTAACGGCTGGTGGTATTG
ACACACACATCCACTTCATTTCACCCCAACAAATCCCTACAGCTTTTGCAAGCGGTGTAACAACTATGATTGGTGGCGGA
ACTGGCCCTGCTGATGGCACTAACGCAACCACTATCACTCCAGGTAGAAGAAATTTAAAATTCATGCTCAGAGCGGCTGA
AGAATATTCTATGAACTTTGGTTTCTTGGCTAAAGGTAATGTTTCTAACGATGCGAGCTTAGCCGATCAGATTGAAGCCG
GTGCGATTGGCTTTAAAATCCACGAAGACTGGGGAACAACTCCTTCTGCAATCAATCATGCATTAGATGTTGCAGACAAA
TACGATGTGCAAGTCGCTATCCACACAGACACTTTGAACGAAGCCGGTTGTGTAGAAGACACTATGGCAGCTATTGCCGG
ACGCACTATGCACACTTTCCACACTGAAGGCGCTGGCGGCGGACACGCTCCTGATATTATTAAAGTAGCCGGTGAACACA
ACATTCTTCCCGCTTCCACTAACCCCACTATCCCTTTCACTGTGAATACAGAAGCAGAACACATGGACATGCTTATGGTG
TGCCACCACTTGGATAAAAGCATTAAAGAAGATGTTCAGTTCGCTGATTCAAGGATCCGCCCTCAAACCATTGCAGCTGA
AGACACTTTGCATGACATGGGGATTTTCTCAATCACCAGTTCTGACTCTCAAGCTATGGGTCGTGTGGGTGAAGTTATCA
CCAGAACTTGGCAAACAGCTGACAAAAACAAAAAAGAATTTGGCCGCTTGAAAGAAGAAAAAGGCGATAACGACAACTTC
AGGATCAAACGCTACTTGTCTAAGTACACCATTAACCCAGCGATCGCTCATGGGATTAGCGAGTATGTAGGTTCTGTGGA
AGTGGGCAAAGTGGCTGACTTGGTATTGTGGAGTCCCGCATTCTTTGGCGTAAAACCCAACATGATCATCAAAGGCGGGT
TCATTGCATTAAGTCAAATGGGTGATGCGAACGCTTCTATCCCTACCCCACAACCAGTTTATTACAGAGAAATGTTCGCT
CATCATGGTAAAGCTAAATATGATGCAAACATCACTTTTGTGTCTCAAGCGGCTTATGACAAAGGCATTAAAGAAGAATT
AGGGCTTGAAAGACAAGTGTTGCCGGTAAAAAATTGCAGAAACATCACCAAAAAAGACATGCAATTCAACGACACTACCG
CTCACATTGAAGTCAATTCTGAAACTTACCATGTGTTCGTGGATGGCAAAGAAGTAACTTCTAAACCAGCCAATAAAGTG
AGCTTGGCGCAACTCTTTAGCATTTTCTAG

Protein sequence :
MKKISRKEYASMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTG
IYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGG
TGPADGTNATTITPGRRNLKFMLRAAEEYSMNFGFLAKGNVSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMV
CHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNF
RIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNSETYHVFVDGKEVTSKPANKV
SLAQLFSIF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 4e-159 62
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 4e-159 62
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-145 59
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-145 59
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 3e-145 59
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-145 59

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureB YP_626814.1 urease subunit beta VFG0270 Protein 0.0 99