Gene Information

Name : HPAG1_0106 (HPAG1_0106)
Accession : YP_626847.1
Strain : Helicobacter pylori HPAG1
Genome accession: NC_008086
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase/cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 110879 - 112021 bp
Length : 1143 bp
Strand : -
Note : catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine

DNA sequence :
ATGCGCATGCAAACAAAACTAATCCATGGGGGCATTAGTGAGGATACGACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCACCATAAGGGTTATGAATACTCTCGCTCAGGCAACCCCACACGCTTTG
CTTTAGAAGAACTCATCGCCGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGACTAGCTGGGATCCACGCT
GTTTTTTCCCTTTTACAATCAGGCGATCATGTGTTATTGGGCGATGATGTTTATGGGGGGACTTTTCGCTTGTTTAATAA
AGTGCTTGTCAAAAATGGGCTTTCTTGCACCATCATAGACACTAGCGATCTATCCCAAATCAAAAAGGCTATCAAGCAAA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGCGCAATGCGCGAGTGTTGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTATCAAAACCCGCTTCTTTTGGGAGCGGA
TATTGTGGTGCATAGCGGCACGAAATACTTAGGCGGGCATAGCGATGTGGTCGCTGGGCTTGTAACCACTAATAATGAAG
CGCTATCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTAGCATTACGCATGGAGGCCCATCAAAAAAACGCTCTTTGCGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTAGAAAAGGTTTATTACCCGGGCTTGCCCACCCACCCTAATTACGAGCTAGCCAAAGCCCAAATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGACAGCGAGGCGACTCTTTTTGTAGAAAGCCTTAAATTATTCATTTTAGGC
GAGAGTTTGGGCGGGGTGGAAAGTTTGGTAGGGATTCCGGCATTTATGACCCATGCGTGTATCCCTAAAGAACAACGAGA
AGCTGCAGGGATTAGAGATGGCTTGGTGCGCTTGTCTGTGGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAGGCTAA

Protein sequence :
MRMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGHHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKQNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALSQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLALRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNYELAKAQMRGFSGMLSFTLKNDSEATLFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 7e-97 54
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-98 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 3e-72 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPAG1_0106 YP_626847.1 cystathionine gamma-synthase/cystathionine beta-lyase BAC0207 Protein 1e-63 44