Gene Information

Name : guaA (Ldb0298)
Accession : YP_618443.1
Strain : Lactobacillus delbrueckii ATCC 11842
Genome accession: NC_008054
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 252912 - 254465 bp
Length : 1554 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCAAAAATCGACTTAAGCAATTTTGACAAGATTATCGTCCTGGACTTCGGCAGCCAGTACAACCAATTGATTACCCG
CCGGATCCGTGACTTTGGCATCTACTCAGAACTTTTGCCGCACACGATTACGGCAGAAGAAGTGAAGAAGATCGCTCCTA
AGGGGATCATCTTCTCCGGCGGCCCGAACTCAGTTTACGATGAAAACGCCCTGGACGTTGACCCGGAAATTTTTGAACTG
GGGATTCCAATCTTGGGTATCTGCTACGGGATGCAACTGATGACCCAGAAGCTGGGCGGGACGGTTGAAAAGGCCGGGGA
AGCTGAATACGGCTCAGCCCACATTGAAGTCAAGGAAGCTGACAGCCCGCTTTACAAGGGCCTGCCAGAAAAGCAGGTTG
TCTGGATGAGCCACGGGGACCTGGTAACCAAGGTGCCAGAAGGCTTTGAAGTTCTGGCTTCAAGCAAGAACTGCCCGATC
GCTTCCATGGCTGACCCAGACCGGAAGTTCTACGCAGTCCAGTTCCACGCTGAAGTCCGCAACTCAGAATATGGCCTGGA
CATCTTGCGCCGTTTTGCCTTTGACGTCTGCGGAGCCAAGGACAACTGGACCATGGATGACTTTATTAAGCTGTCTGTTG
ACTCAATCAGAGAAGAAGTCGGCAACGCCAATGTGATCCTGGGGATCTCCGGCGGGGTTGACTCCAGCGTTACGGCTACC
CTTTTGCACAAGGCAATCGGTAGCCAGCTGACGGCGATTTTTGTCGACCACGGCCTGCTTAGAAAGAACGAAAGCGATGA
AGTTATGGCCGCACTTAAGGAAGGGCTGGGCGTGAACATCGTCAGAGTTGATGCTAAGGACCGCTTCATGTCCAAGCTGG
CTGGGGTAACCGACCCAGAAAAGAAGCGGAAGATCATCGGCAACGAATTCGTGCAGGTCTTCAACGATGAAGCCAAGAAG
ATCAAGGACGCCAAGTTCCTGGCCCAAGGGACCTTGTACACTGACGTAATTGAATCAGGGACCGACACGGCCCACACGAT
CAAGAGCCACCACAATGTCGGGGGCTTGCCGGAAGACATGCAGTTCAAGCTGATTGAACCGCTGCGGCAATTGTTCAAGG
ACGAAGTTCGGGTCTTGGGTGAAAAGCTGGGTCTGCCACACGACTTGGTATGGCGGCAGCCGTTCCCAGGTCCTGGCCTG
GCTATCCGGGTAATCGGGGAGATCACTGAAGAGAAGCTGCGGATCGTCCGGGACGCGGACGCGATCTTGCGGGAAGAAGT
CAAGAATGCAGGCTTGCAGGAAAGCATTTGGCAATACTTTGTTGCTTTGCCAGGGATGCGGAGCGTCGGGGTTATGGGAG
ACGGCCGGACTTACGACTATGCTGTCTGCATCCGGGCCGTTACGTCAATTGACGGGATGACGGCTGACTTTGCCCAGATT
CCATGGGATGTTCTGCAGAAGATCTCCGTGCGGATCGTCAACGAAGTCAAGCAGGTTAACCGCGTACTGTACGACGTGAC
GAGCAAGCCGCCGGCAACGATTGAATATGAATAA

Protein sequence :
MAKIDLSNFDKIIVLDFGSQYNQLITRRIRDFGIYSELLPHTITAEEVKKIAPKGIIFSGGPNSVYDENALDVDPEIFEL
GIPILGICYGMQLMTQKLGGTVEKAGEAEYGSAHIEVKEADSPLYKGLPEKQVVWMSHGDLVTKVPEGFEVLASSKNCPI
ASMADPDRKFYAVQFHAEVRNSEYGLDILRRFAFDVCGAKDNWTMDDFIKLSVDSIREEVGNANVILGISGGVDSSVTAT
LLHKAIGSQLTAIFVDHGLLRKNESDEVMAALKEGLGVNIVRVDAKDRFMSKLAGVTDPEKKRKIIGNEFVQVFNDEAKK
IKDAKFLAQGTLYTDVIESGTDTAHTIKSHHNVGGLPEDMQFKLIEPLRQLFKDEVRVLGEKLGLPHDLVWRQPFPGPGL
AIRVIGEITEEKLRIVRDADAILREEVKNAGLQESIWQYFVALPGMRSVGVMGDGRTYDYAVCIRAVTSIDGMTADFAQI
PWDVLQKISVRIVNEVKQVNRVLYDVTSKPPATIEYE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-170 67
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-170 67
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-170 67
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-129 51