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Name : ureC (TM1040_0385) Accession : YP_612380.1 Strain : Ruegeria sp. TM1040 Genome accession: NC_008044 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 393082 - 394794 bp Length : 1713 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGCCCGCCAACATCCCTCGCTCTGACTATGCCGCCATGTATGGGCCGACCACCGGCGACCGCGTGCGGCTGGCCGATAC TGACCTGATCATCGAGGTGGAGCGCGACCTCACCGGCCCTTACGGCGAAGAGGTCAAATTTGGCGGCGGCAAGGTGATCC GCGACGGGATGGGACAGGCGCAGACGACGCGCGCGGGCGGCGCGGTCGATACCGTGATTACCAACGCGCTGATCCTTGAT TGGACCGGCATCTACAAGGCTGACGTCGGGCTGAAAGACGGGCGCATCCATGCCATCGGTAAGGCCGGCAACCCCGACAC TCAACCCAATGTGACCATTATCGTTGGCCCCGGCACCGAGGTGATCGCGGGCGAAGGGCGCATCCTGACGGCAGGCGGGT TTGACAGCCATATCCATTATATCTGCCCGCAACAGATCGAGGATGCGCTGCACTCGGGTCTGACCACCATGCTCGGCGGC GGCACCGGGCCAGCCCATGGGACTTTGGCCACCACCTGCACCCCCGGTGCCTGGCACCTGGGTCGGATGATGCAGGCCGC AGATGCGTTTCCGATGAACCTGGCGTTTGCAGGCAAAGGGAATGCCTCGCTGCCCGCCGCCATTGAAGAACAGGTTAACG CAGGCGCCTGCGCGCTGAAACTGCATGAGGACTGGGGCACCACACCCGCTGCCATCGACTGCTGCCTCGGGGTGGCCGAT GCAATGGATGTGCAGGTGATGATCCATACAGACACGCTCAATGAGTCGGGGTTTGTGGAACACACCGTCAAGGCCATGAA AGGCCGCACCATCCACGCCTTTCACACCGAAGGTGCGGGCGGTGGCCACGCACCGGACATCATCAAGATCTGCGGTGAGG AGTTCGTGTTGCCCTCCTCGACCAACCCGACCCGCCCCTTCACCGTGAACACCATCGAAGAGCACCTCGACATGCTCATG GTCTGTCATCACCTCGACAAATCCATCCCCGAGGATGTGGCCTTTGCCGAGAGCCGGATCCGGCGCGAAACCATTGCCGC CGAGGACATCCTGCACGACATGGGGGCCTTCTCGATCATCGCAAGCGACAGCCAGGCGATGGGACGCGTGGGCGAGGTCA TCATTCGCACATGGCAGACCGCAGACAAGATGAAGAAACAGCGCGGCCGCCTGAGCGAGGAAACAGGTGAGAACGACAAC TTTCGCGTGCGGCGCTATGTGGCAAAATACACCATCAACCCGGCGATCGCGCATGGGATCGCGCATGAAATTGGCTCTAT CGAGGTGGGCAAGCGCGCGGATCTGGTGCTGTGGAACCCAGCCTTCTTTGGTGTAAAGCCCGAGATGGTCCTGATGGGCG GCACCATCGCCTGCGCGCAAATGGGCGATCCCAACGCCTCCATTCCGACGCCGCAGCCGGTCTATTCGCGTCCCATGTGG GGCGCTTACGGGCGCTCGGTCGAGCATTCTGCCGTCACCTTTGTGTCCGAGGCCGCGCAGGCCGCAGGCATCGGTAAGAC ACTGGGTCTTGCAAAACAGACACTTGCGGTAAAGGGCACACGCGGGATCGGGAAGTCAGCACTCAAGCTCAACACCGCCA CGCCTGAGATCGAGGTTCACCCTGAAACCTATGAGGTACGCGCGAATGGGGAGCTTTTGACCTGTCAGCCCGCCGAGGAA CTGCCCTTGGCACAGCGATATTTCCTCTTCTAA Protein sequence : MPANIPRSDYAAMYGPTTGDRVRLADTDLIIEVERDLTGPYGEEVKFGGGKVIRDGMGQAQTTRAGGAVDTVITNALILD WTGIYKADVGLKDGRIHAIGKAGNPDTQPNVTIIVGPGTEVIAGEGRILTAGGFDSHIHYICPQQIEDALHSGLTTMLGG GTGPAHGTLATTCTPGAWHLGRMMQAADAFPMNLAFAGKGNASLPAAIEEQVNAGACALKLHEDWGTTPAAIDCCLGVAD AMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEFVLPSSTNPTRPFTVNTIEEHLDMLM VCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSIIASDSQAMGRVGEVIIRTWQTADKMKKQRGRLSEETGENDN FRVRRYVAKYTINPAIAHGIAHEIGSIEVGKRADLVLWNPAFFGVKPEMVLMGGTIACAQMGDPNASIPTPQPVYSRPMW GAYGRSVEHSAVTFVSEAAQAAGIGKTLGLAKQTLAVKGTRGIGKSALKLNTATPEIEVHPETYEVRANGELLTCQPAEE LPLAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-176 | 68 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-176 | 68 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 9e-166 | 61 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-166 | 61 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 4e-166 | 61 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-166 | 61 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_612380.1 | urease subunit alpha | VFG0270 | Protein | 3e-162 | 64 |
