Gene Information

Name : TM1040_3468 (TM1040_3468)
Accession : YP_611702.1
Strain :
Genome accession: NC_008043
Putative virulence/resistance : Virulence
Product : 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.8
Position : 492552 - 494063 bp
Length : 1512 bp
Strand : -
Note : KEGG: sil:SPOA0027 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase, ev=0.0, 78% identity; TIGRFAM: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase: (0); PFAM: aldehyde dehydrogenase: (1.2e-243)

DNA sequence :
ATGAGCGACCTCGCCGTCAACCTCGACAAACTCGCAGGTTTTCTCGAAGAATACCGAAAATCCGGCATCACCAACCTCAT
TGGCGGCGAGGCCCGCCCCGCCGCCTCCGGCCAGACGTTTGAAACGACCTCGCCGGTGGATGAGAGCGTGATCTGCTCGG
TGGCCCGCGGCGGGTCCGAGGACATAGATGCAGCCGCACAGGCCGCCAAAGCCGCCTTCCCCGCATGGCGCGACCTGCCC
GCGACCGAACGCAAGGCGATCCTGCACCGCATCGCAGATGGGATTGTGGAACGGGCCGAGGAAATCGCGCTCTGCGAGTG
CTGGGACACCGGTCAGGCGCTGCGCTTCATGTCCAAAGCGGCCCTGCGCGGAGCAGAGAATTTTCGCTTCTTTGCCGACC
GTGCGCCTTCGGCCCGCGATGGTCAGATGCTGCCCTCGCCCACCTTGATGAATGTCACCACCCGTGTGCCGATCGGCCCT
GTGGGTGTCATCACACCCTGGAATACGCCCTTCATGCTCTCCACATGGAAGATCGCGCCTGCCTTGGCCGCGGGCTGCAC
CGTCGTCCATAAACCGGCAGAGTTCTCGCCCCTGACGGCCCGTATTCTGGCGGAGATCGCCCATGATGCGGGCCTGCCCC
CCGGCGTCTGGAACCTCGTCAACGGCCTCGGCGAAGAGGCCGGCAAGGCGCTCACCGAACATCCCGACATCAAGGCCATC
GCCTTTGTCGGTGAGAGCAAAACCGGCTCGATGATCATGGCCCAAGGCGCGCCGACCCTGAAACGTGTGCATTTTGAACT
CGGCGGCAAGAACCCGGTGGTGGTCTTTGACGATGCCGATCTCGACCGGGCCTTGGACGCGGCGATCTTCATGATCTACT
CGCTGAATGGCGAGCGCTGCACCTCTTCCTCGCGCCTGCTCATTCAGGACAGCATCGCCGAGGCATTCGAGGCCAAACTG
CTCGCGCGTGTAAACAGCATCAAGGTCGGCCACCCGCTTGACCCCCAAACCGAGGTCGGCCCGCTCATTCACAAGACCCA
CTTCGACAAGGTGACCTCCTATTTCGACATCGCGCGGCACGATGGCGCCACCGTCGCCGCAGGTGGCAGCCGCCACGGCG
ACACCGGCTGGTTTGTCAAACCCACGCTCTTTACCGGGGCCACCAATCAGATGACCATCGCCCGCGAGGAAATCTTCGGC
CCGGTCCTCACCGCCATCCGCTTCACCGACGAAGACGAGGCGCTGAACATCGCCAATGACACCCAATATGGCCTCACCGC
CTATGTCTGGACCAACGATGTGACCCGCGCCATGCGCTTCACCAACCAGCTTGAGGCCGGGATGATCTGGGTGAACTCGG
AAAACGTCCGCCACCTGCCTACGCCCTTTGGTGGGGTCAAGGCTTCCGGGATCGGGCGCGACGGCGGCGACTGGAGCTTT
GAGTTCTACATGGAACAGAAACACATCGGCTTTGCCACCGGCCACCACAAGATCCCCCGCCTCGGCGCCTGA

Protein sequence :
MSDLAVNLDKLAGFLEEYRKSGITNLIGGEARPAASGQTFETTSPVDESVICSVARGGSEDIDAAAQAAKAAFPAWRDLP
ATERKAILHRIADGIVERAEEIALCECWDTGQALRFMSKAALRGAENFRFFADRAPSARDGQMLPSPTLMNVTTRVPIGP
VGVITPWNTPFMLSTWKIAPALAAGCTVVHKPAEFSPLTARILAEIAHDAGLPPGVWNLVNGLGEEAGKALTEHPDIKAI
AFVGESKTGSMIMAQGAPTLKRVHFELGGKNPVVVFDDADLDRALDAAIFMIYSLNGERCTSSSRLLIQDSIAEAFEAKL
LARVNSIKVGHPLDPQTEVGPLIHKTHFDKVTSYFDIARHDGATVAAGGSRHGDTGWFVKPTLFTGATNQMTIAREEIFG
PVLTAIRFTDEDEALNIANDTQYGLTAYVWTNDVTRAMRFTNQLEAGMIWVNSENVRHLPTPFGGVKASGIGRDGGDWSF
EFYMEQKHIGFATGHHKIPRLGA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hpaE AAO17179.1 HpaE Not tested tcd island Protein 2e-89 46
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-73 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 3e-74 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 3e-74 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 3e-74 41
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 8e-62 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 7e-74 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TM1040_3468 YP_611702.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase VFG0082 Protein 5e-74 41