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Name : secA (MGAS10750_Spy1593) Accession : YP_603087.1 Strain : Streptococcus pyogenes MGAS10750 Genome accession: NC_008024 Putative virulence/resistance : Unknown Product : preprotein translocase subunit SecA Function : - COG functional category : U : Intracellular trafficking, secretion and vesicular transport COG ID : COG0653 EC number : - Position : 1528598 - 1531117 bp Length : 2520 bp Strand : - Note : functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis ap DNA sequence : ATGGCCAATATTCTACGCAAAGTTATCGAAAATGACAAAGGCGAACTAAGAAAATTAGAAAAAATTGCAAAAAAAGTAGA ATCCTACGCAGACCAAATGGCGTCATTGTCGGATAGAGATCTACAAGGAAAAACACTTGAATTTAAAGAACGCTATCAAA AAGGTGAGACCCTCGAACAACTATTACCTGAAGCTTTCGCAGTTGTTCGTGAAGCAGCAAAACGTGTGTTGGGCTTGTTC CCTTATCGTGTTCAAATTATGGGAGGAATTGTTCTTCATAACGGGGATGTCCCTGAAATGCGTACTGGTGAAGGAAAAAC TCTTACAGCTACCATGCCAGTTTATCTCAATGCTATTGCTGGTGAAGGTGTTCACGTTATTACTGTTAATGAGTATCTTT CAACGCGTGACGCTACCGAAATGGGTGAAGTGTATAGCTGGTTAGGTCTTTCAGTTGGGATCAACCTAGCTGCTAAGTCT CCTGCTGAAAAACGTGAAGCTTATAATTGTGATATTACTTATTCAACCAACTCTGAAGTCGGTTTTGATTACCTTCGTGA CAACATGGTTGTTCGCCAGGAAGACATGGTACAACGCCCACTCAATTTTGCCTTGGTTGATGAAGTGGACTCAGTCTTAA TTGACGAGGCAAGGACACCTTTAATTGTTTCTGGTGCTGTTAGCTCTGAAACCAATCAATTGTATATTCGTGCTGACATG TTTGTAAAAACTCTGACGTCAGTGGATTATGTTATTGATGTGCCCACTAAAACGATTGGATTAAGCGATTCAGGTATTGA TAAAGCTGAGAGTTATTTTAACTTGAGCAATCTTTACGATATTGAAAATGTAGCCTTGACTCACTTTATAGACAACGCCC TTCGTGCAAACTATATTATGTTGTTAGATATCGATTATGTGGTCAGCGAAGATGGTGAGATTCTTATTGTTGACCAATTT ACAGGTCGTACGATGGAAGGGCGTCGCTTCTCAGACGGCTTGCACCAAGCTATTGAGGCAAAAGAAGGCGTTCGTATTCA GGAAGAATCAAAAACCAGCGCCTCAATCACTTACCAAAATATGTTTCGTATGTACAAAAAATTGGCAGGTATGACTGGTA CTGCGAAAACCGAGGAAGAAGAATTTCGCGAAGTTTATAACATGCGTATTATTCCAATTCCAACCAATCGTCCAATTGCC CGTATTGATCACACTGATTTGCTTTACCCGACCTTAGAATCAAAGTTTAGAGCAGTTGTGGAAGACGTTAAAACGCGTCA TGCAAAAGGACAACCTATCCTTGTAGGTACGGTTGCTGTTGAAACTAGTGATTTGATTTCACGCAAGCTGGTTGAAGCAG GGATTCCTCATGAGGTTTTGAATGCTAAAAATCACTTTAAAGAAGCTCAAATCATTATGAATGCTGGGCAACGTGGTGCT GTTACAATCGCAACTAACATGGCTGGTCGTGGTACTGATATCAAGCTTGGTGAAGGTGTTCGTGAACTTGGTGGGTTATG TGTCATTGGTACAGAGCGTCATGAAAGCCGTCGTATCGATAACCAGCTTCGTGGACGTTCAGGTCGTCAAGGAGATCCAG GTGAATCCCAATTCTATCTTTCATTAGAAGATGATTTGATGAGACGTTTCGGCTCTGATCGTATAAAAGCCTTTTTGGAT CGGATGAAACTAGATGAAGAAGACACTGTTATTAAATCAGGTATGTTAGGGCGTCAAGTGGAATCTGCTCAAAAACGGGT TGAAGGAAATAACTACGATACCCGTAAACAGGTCTTACAATACGATGATGTGATGCGTGAACAGCGTGAAATTATCTATG CTAACCGTCGTGATGTCATAACTGCTAATCGAGATCTTGGCCCAGAAATTAAAGCTATGATCAAGCGTACTATCGACCGT GCTGTAGATGCTCATGCACGTAGCAATCGTAAGGATGCTGTGGATGCCATTGTGACCTTTGCACGCACGTCACTTGTTCC AGAAGAGTCTATCAGTGCTAAAGAGTTACGTGGTTTAAAAGACGAACAAATCAAAGAGAAGCTTTATCAAAGAGCGCTTG CTATCTACGACCAGCAACTATCAAAACTTCGTGATCAAGAAGCTATTATTGAATTCCAAAAAGTACTCATTTTGATGATT GTGGATAACAAATGGACTGAACACATTGATGCCTTAGATCAACTTCGTAATGCTGTTGGACTTCGAGGGTATGCTCAAAA TAACCCTGTGGTGGAATACCAAGCAGAAGGTTTCAAGATGTTCCAAGATATGATTGGTGCTATCGAGTTTGATGTAACAC GTACCATGATGAAAGCACAAATTCACGAACAAGAACGTGAACGTGCAAGTCAACGTGCCACAACAGCAGCACCTCAAAAC ATCCAATCGCAGCAGTCAGCTAACACCGATGATTTACCCAAAGTGGAGCGTAACGAAGCTTGTCCATGTGGTTCAGGCAA AAAATTCAAAAATTGTCACGGTCGTAAATCCTTCTCATAA Protein sequence : MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQLLPEAFAVVREAAKRVLGLF PYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKS PAEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADM FVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQF TGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGA VTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFGSDRIKAFLD RMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDR AVDAHARSNRKDAVDAIVTFARTSLVPEESISAKELRGLKDEQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMI VDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAPQN IQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| secA2 | YP_006310687.1 | preprotein translocase subunit SecA2 | Not tested | FWisland_3 | Protein | 2e-143 | 41 |
